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Items: 1 to 20 of 31

1.
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai, Xiaoping Zhu
Mol Brain. 2024; 17: 12. Published online 2024 Feb 26. doi: 10.1186/s13041-024-01081-x
PMCID:
PMC10898105
AbstractArticlePDF–4.3M
2.
TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair
Jinghui Xu, Liying Zhang, Mingyue Li, Xiaofei He, Jing Luo, Rui Wu, Zhongqiu Hong, Haiqing Zheng, Xiquan Hu
J Neuroinflammation. 2023; 20: 50. Published online 2023 Feb 25. doi: 10.1186/s12974-023-02741-w
PMCID:
PMC9960657
AbstractArticlePDF–16M
3.
Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant
Marc D. Tambini, Luciano D’Adamio
Sci Rep. 2020; 10: 4122. Published online 2020 Mar 5. doi: 10.1038/s41598-020-60800-1
PMCID:
PMC7058057
AbstractArticlePDF–4.4M
4.
TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs
Pei Ye, Dawei Xu, Jinhuang Xu, Guiwang Liu, Shenghui Huang, Weiqiong Zhang, Peizhong Zheng, Jianhua Li, Jianrong Huang
Mol Med Rep. 2017 Oct; 16(4): 4777–4783. Published online 2017 Aug 10. doi: 10.3892/mmr.2017.7212
PMCID:
PMC5647029
AbstractArticlePDF–1.4M
5.
Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway
Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Hao
J Neuroimmune Pharmacol. 2023; 18(3): 476–494. Published online 2023 Sep 2. doi: 10.1007/s11481-023-10081-y
PMCID:
PMC10577109
AbstractArticlePDF–4.0M
6.
DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke
Ludmila Belayev, Sung‐Ha Hong, Raul S. Freitas, Hemant Menghani, Shawn J. Marcell, Larissa Khoutorova, Pranab K. Mukherjee, Madigan M. Reid, Reinaldo B. Oria, Nicolas G. Bazan
CNS Neurosci Ther. 2020 Nov; 26(11): 1155–1167. Published online 2020 Aug 5. doi: 10.1111/cns.13444
PMCID:
PMC7564189
AbstractArticlePDF–2.8M
7.
Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis
Wurong Li, Haoxiao Chang, Wenqing Wu, Dongmei Xu, Meijuan Jiang, Junhua Gao, Yuming Huang, Yun Xu, Linlin Yin, Xinghu Zhang
Front Neurol. 2020; 11: 62. Published online 2020 Feb 5. doi: 10.3389/fneur.2020.00062
PMCID:
PMC7013092
AbstractArticlePDF–756K
8.
TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus
Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang, Jianliang Fu
J Neuroinflammation. 2020; 17: 2. Published online 2020 Jan 3. doi: 10.1186/s12974-019-1688-9
PMCID:
PMC6942413
AbstractArticlePDF–3.5M
9.
TREM2 triggers microglial density and age‐related neuronal loss
Bettina Linnartz‐Gerlach, Liviu‐Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neumann
Glia. 2019 Mar; 67(3): 539–550. Published online 2018 Dec 11. doi: 10.1002/glia.23563
PMCID:
PMC6590266
AbstractArticlePDF–6.5M
10.
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease
Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth
Mol Neurodegener. 2018; 13: 29. Published online 2018 Jun 1. doi: 10.1186/s13024-018-0262-8
PMCID:
PMC5984804
AbstractArticlePDF–1.6M
11.
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman
Proc Natl Acad Sci U S A. 2017 Oct 24; 114(43): 11524–11529. Published online 2017 Oct 9. doi: 10.1073/pnas.1710311114
PMCID:
PMC5663386
AbstractArticlePDF–1.4M
12.
TREM2 protects against cerebral ischemia/reperfusion injury
Rong Wu, Xiangpen Li, Pengfei Xu, Likui Huang, Jinping Cheng, Xiaolong Huang, Jingru Jiang, Long-Jun Wu, Yamei Tang
Mol Brain. 2017; 10: 20. Published online 2017 Jun 7. doi: 10.1186/s13041-017-0296-9
PMCID:
PMC5461720
AbstractArticlePDF–4.1M
13.
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Daniel L Kober, Jennifer M Alexander-Brett, Celeste M Karch, Carlos Cruchaga, Marco Colonna, Michael J Holtzman, Thomas J Brett
eLife. 2016; 5: e20391. Published online 2016 Dec 20. doi: 10.7554/eLife.20391
PMCID:
PMC5173322
AbstractArticlePDF–3.8M
14.
Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression
Daniel W. Sirkis, Luke W. Bonham, Renan E. Aparicio, Ethan G. Geier, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Zachary A. Miller, Bruce L. Miller, Giovanni Coppola, Jennifer S. Yokoyama
Acta Neuropathol Commun. 2016; 4(1): 98. Published online 2016 Sep 2. doi: 10.1186/s40478-016-0367-7
PMCID:
PMC5010724
AbstractArticlePDF–1.2M
15.
Diesel exhaust impairs TREM2 to dysregulate neuroinflammation
Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti, Michelle L. Block
J Neuroinflammation. 2020; 17: 351. Published online 2020 Nov 22. doi: 10.1186/s12974-020-02017-7
PMCID:
PMC7682066
AbstractArticlePDF–3.8M
16.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
Faten A. Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A. Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, Li Gan
Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): 10172–10177. Published online 2018 Sep 19. doi: 10.1073/pnas.1811411115
PMCID:
PMC6176614
AbstractArticlePDF–1.5M
17.
TREM2 maintains microglial metabolic fitness in Alzheimer’s disease
Tyler K. Ulland, Wilbur M Song, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna
Cell. Author manuscript; available in PMC 2018 Aug 10.
Published in final edited form as: Cell. 2017 Aug 10; 170(4): 649–663.e13. doi: 10.1016/j.cell.2017.07.023
PMCID:
PMC5573224
AbstractArticlePDF–2.7M
18.
TREM2 regulates microglial cell activation in response to demyelination in vivo
Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M. Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S. Klein, Anne H. Cross, Karel Otero, Laura Piccio
Acta Neuropathol. Author manuscript; available in PMC 2016 Mar 1.
Published in final edited form as: Acta Neuropathol. 2015 Mar; 129(3): 429–447. Published online 2015 Jan 29. doi: 10.1007/s00401-015-1388-1
PMCID:
PMC4667728
AbstractArticlePDF–3.0M
19.
DAP12/TREM2 Deficiency Results in Impaired Osteoclast Differentiation and Osteoporotic Features
Juha Paloneva, Jami Mandelin, Anna Kiialainen, Tom Böhling, Johannes Prudlo, Panu Hakola, Matti Haltia, Yrjö T. Konttinen, Leena Peltonen
J Exp Med. 2003 Aug 18; 198(4): 669–675. doi: 10.1084/jem.20030027
PMCID:
PMC2194176
AbstractArticlePDF–376K
20.
An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass
EMBO Mol Med. 2017 Oct; 9(10): 1356–1365. Published online 2017 Aug 30. doi: 10.15252/emmm.201707672
PMCID:
PMC5623859
AbstractArticlePDF–1.1M

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