PMC Links for Gene (Select 58950) - PMC

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Items: 19

Select item 58008901.

Dissociation of FK506-Binding Protein 12.6 kD from Ryanodine Receptor in Bronchial Smooth Muscle Cells in Airway Hyperresponsiveness in Asthma

Ying Du, Jianhong Zhao, Xi Li, Si Jin, Wan-Li Ma, Qing Mu, Shuxiang Xu, Jie Yang, Shanshan Rao, Liping Zhu, Jianbao Xin, Peng-Cheng Cai, Yunchao Su, Hong Ye

Am J Respir Cell Mol Biol. 2014 Feb; 50(2): 398–408. doi: 10.1165/rcmb.2013-0222OC

PMCID:: PMC5800890

Abstract Article PDF–1.9M

Select item 57839602.

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca²⁺], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats

John C. Gant, Eric M. Blalock, Kuey-Chu Chen, Inga Kadish, Olivier Thibault, Nada M. Porter, Philip W. Landfield

J Neurosci. 2018 Jan 24; 38(4): 1030–1041. doi: 10.1523/JNEUROSCI.2234-17.2017

PMCID:: PMC5783960

Abstract Article PDF–1.2M

Select item 45180583.

Reversal of Aging-Related Neuronal Ca²⁺ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus

John C. Gant, Kuey-Chu Chen, Inga Kadish, Eric M. Blalock, Olivier Thibault, Nada M. Porter, Philip W. Landfield

J Neurosci. 2015 Jul 29; 35(30): 10878–10887. doi: 10.1523/JNEUROSCI.1248-15.2015

PMCID:: PMC4518058

Abstract Article PDF–2.3M

Select item 30923714.

Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca²⁺-Dysregulation Aging Phenotype in Hippocampal Neurons

John C. Gant, Kuey-Chu Chen, Christopher M. Norris, Inga Kadish, Olivier Thibault, Eric M. Blalock, Nada M. Porter, Philip W. Landfield

J Neurosci. 2011 Feb 2; 31(5): 1693–1703. doi: 10.1523/JNEUROSCI.4805-10.2011

PMCID:: PMC3092371

Abstract Article PDF–1.4M

Select item 28120355.

FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia

Zheng Chen, Zhengzheng Li, Bin Wei, Wenxuan Yin, Tao Xu, Michael I. Kotlikoff, Guangju Ji

FASEB J. 2010 Feb; 24(2): 357–363. doi: 10.1096/fj.09-138446

PMCID:: PMC2812035

Abstract Article

Select item 32837086.

FKBP12 Activates the Cardiac Ryanodine Receptor Ca²⁺-Release Channel and Is Antagonised by FKBP12.6

Elena Galfré, Samantha J. Pitt, Elisa Venturi, Mano Sitsapesan, Nathan R. Zaccai, Krasimira Tsaneva-Atanasova, Stephen O'Neill, Rebecca Sitsapesan

PLoS One. 2012; 7(2): e31956. Published online 2012 Feb 21. doi: 10.1371/journal.pone.0031956

PMCID:: PMC3283708

Abstract Article PDF–1.4M

Select item 32326347.

Transgenic Analysis of the Role of FKBP12.6 in Cardiac Function and Intracellular Calcium Release

Ying Liu, Hanying Chen, Guangju Ji, Baiyan Li, Peter J. Mohler, Zhiming Zhu, Weidong Yong, Zhuang Chen, Xuehong Xu, Hongbo Xin, Weinian Shou

Assay Drug Dev Technol. 2011 Dec; 9(6): 620–627. doi: 10.1089/adt.2011.0411

PMCID:: PMC3232634

Abstract Article PDF–528K

Select item 27611998.

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not β-adrenergic stimulation in mouse cardiomyocytes

Xu Zhang, Yvonne N. Tallini, Zheng Chen, Lu Gan, Bin Wei, Robert Doran, Lin Miao, Hong-Bo Xin, Michael I. Kotlikoff, Guangju Ji

Cardiovasc Res. 2009 Nov 1; 84(2): 253–262. Published online 2009 Jul 3. doi: 10.1093/cvr/cvp212

PMCID:: PMC2761199

Abstract Article PDF–563K

Select item 14725439.

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

Stephan E. Lehnart, Cecile Terrenoire, Steven Reiken, Xander H. T. Wehrens, Long-Sheng Song, Erik J. Tillman, Salvatore Mancarella, James Coromilas, W. J. Lederer, Robert S. Kass, Andrew R. Marks

Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7906–7910. Published online 2006 May 3. doi: 10.1073/pnas.0602133103

PMCID:: PMC1472543

Abstract Article PDF–1.1M

Select item 221746610.

RYR2 Proteins Contribute to the Formation of Ca²⁺ Sparks in Smooth Muscle

Guangju Ji, Morris E. Feldman, Kai Su Greene, Vincenzo Sorrentino, Hong-Bo Xin, Michael I. Kotlikoff

J Gen Physiol. 2004 Apr; 123(4): 377–386. doi: 10.1085/jgp.200308999

PMCID:: PMC2217466

Abstract Article PDF–1.0M

Select item 28356411.

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

Sigrid Dubois, Weinian Shou, Laura S. Haneline, Sidney Fleischer, Thomas A. Waldmann, Jürgen R. Müller

Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14169–14174. Published online 2003 Nov 6. doi: 10.1073/pnas.2335979100

PMCID:: PMC283564

Abstract Article PDF–456K

Select item 315622012.

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

Jérémy Fauconnier, Albano C. Meli, Jérôme Thireau, Stephanie Roberge, Jian Shan, Yassine Sassi, Steven R. Reiken, Jean-Michel Rauzier, Alexandre Marchand, David Chauvier, Cécile Cassan, Christine Crozier, Patrice Bideaux, Anne-Marie Lompré, Etienne Jacotot, Andrew R. Marks, Alain Lacampagne

Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32): 13258–13263. Published online 2011 Jul 25. doi: 10.1073/pnas.1100286108

PMCID:: PMC3156220

Abstract Article PDF–758K

Select item 122319113.

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6.

Christopher H George, Rina Sorathia, Benedicte M A Bertrand, F Anthony Lai

Biochem J. 2003 Mar 1; 370(Pt 2): 579–589. doi: 10.1042/BJ20021433

PMCID:: PMC1223191

Summary PDF–364K

Select item 289542914.

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

Tao Guo, Razvan L. Cornea, Sabine Huke, Emmanuel Camors, Yi Yang, Eckard Picht, Bradley R. Fruen, Donald M. Bers

Circ Res. Author manuscript; available in PMC 2011 Jun 11.

Published in final edited form as: Circ Res. 2010 Jun 11; 106(11): 1743–1752. Published online 2010 Apr 29. doi: 10.1161/CIRCRESAHA.110.219816

PMCID:: PMC2895429

Abstract Article PDF–857K

Select item 282437715.

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

Jérémy Fauconnier, Jérôme Thireau, Steven Reiken, Cécile Cassan, Sylvain Richard, Stefan Matecki, Andrew R. Marks, Alain Lacampagne

Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4): 1559–1564. Published online 2010 Jan 4. doi: 10.1073/pnas.0908540107

PMCID:: PMC2824377

Abstract Article PDF–1.1M

Select item 276043216.

Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias

Jianmin Xiao, Xixi Tian, Peter P. Jones, Jeff Bolstad, Huihui Kong, Ruiwu Wang, Lin Zhang, Henry J. Duff, Anne M. Gillis, Sidney Fleischer, Michael Kotlikoff, Julio A. Copello, S. R. Wayne Chen

J Biol Chem. Author manuscript; available in PMC 2009 Oct 12.

Published in final edited form as: J Biol Chem. 2007 Nov 30; 282(48): 34828–34838. Published online 2007 Oct 5. doi: 10.1074/jbc.M707423200

PMCID:: PMC2760432

Abstract Article PDF–1.6M

Select item 141392517.

Analysis of calstabin2 (FKBP12.6)–ryanodine receptor interactions: Rescue of heart failure by calstabin2 in mice

Fannie Huang, Jian Shan, Steven Reiken, Xander H. T. Wehrens, Andrew R. Marks

Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9): 3456–3461. Published online 2006 Feb 15. doi: 10.1073/pnas.0511282103

PMCID:: PMC1413925

Abstract Article PDF–1.0M

Select item 290187818.

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, S.-L. Catherine Jin, Marco Conti, Andrew R. Marks

Cell. Author manuscript; available in PMC 2010 Jul 12.

Published in final edited form as: Cell. 2005 Oct 7; 123(1): 25–35. doi: 10.1016/j.cell.2005.07.030