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Select item 113644351.

Inhibition of ULK1/2 and KRAS^G12C controls tumor growth in preclinical models of lung cancer

Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin McMahon

eLife. 2024; 13: RP96992. Published online 2024 Aug 30. doi: 10.7554/eLife.96992

PMCID:: PMC11364435

Abstract Article PDF–5.1M

Select item 107800382.

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia

Justine Lai, Claire Yang, Chuquan Shang, Will Chen, Michael P. Chu, Joseph Brandwein, Raymond Lai, Peng Wang

Int J Mol Sci. 2024 Jan; 25(1): 646. Published online 2024 Jan 4. doi: 10.3390/ijms25010646

PMCID:: PMC10780038

Abstract Article PDF–5.0M

Select item 106264383.

An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration

Peigang Liang, Jiaqi Zhang, Yuchen Wu, Shanyuan Zheng, Zhaopeng Xu, Shuo Yang, Jinfang Wang, Suibin Ma, Li Xiao, Tianhui Hu, Wenxue Jiang, Chaoqun Huang, Qiong Xing, Mondira Kundu, Bo Wang

EMBO Rep. 2023 Nov; 24(11): e56850. Published online 2023 Oct 17. doi: 10.15252/embr.202356850

PMCID:: PMC10626438

Abstract Article PDF–13M

Select item 102754114.

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Apirat Chaikuad, Sebastian E. Koschade, Alexandra Stolz, Katarina Zivkovic, Shabnam Shaid, Huiyu Ren, Lester J. Lambert, Nicholas D.P. Cosford, Christian H. Brandts, Stefan Knapp

Biochem J. Author manuscript; available in PMC 2023 Jun 16.

Published in final edited form as: Biochem J. 2019 Mar 12; 476(5): 875–887. Published online 2019 Mar 12. doi: 10.1042/BCJ20190038

PMCID:: PMC10275411

Abstract Article PDF–2.2M

Select item 92626145.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91197366.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88970227.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 88125928.

Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population

Won Sub Kang, Sang Min Lee, Dongkee Hwang, Hae Jeong Park, Jong Woo Kim

Medicine (Baltimore) 2022 Feb 4; 101(5): e28745. Published online 2022 Feb 4. doi: 10.1097/MD.0000000000028745

PMCID:: PMC8812592

Abstract Article PDF–241K

Select item 85710549.

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

Juan F. Linares, Xiao Zhang, Anxo Martinez-Ordoñez, Angeles Duran, Hiroto Kinoshita, Hiroaki Kasashima, Naoko Nakanishi, Yuki Nakanishi, Ryan Carelli, Luca Cappelli, Esperanza Arias, Masakazu Yashiro, Masaichi Ohira, Sanjay Patel, Giorgio Inghirami, Massimo Loda, Ana Maria Cuervo, Maria T. Diaz-Meco, Jorge Moscat

Mol Cell. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cell. 2021 Nov 4; 81(21): 4509–4526.e10. Published online 2021 Sep 23. doi: 10.1016/j.molcel.2021.08.039

PMCID:: PMC8571054

Abstract Article PDF–4.2M

Select item 825771210.

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

David Schlütermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Olena Friesen, Wenxian Wu, Fabian Stuhldreier, Yadong Sun, Lena Berning, Annabelle Friedrich, María José Mendiburo, Christoph Peter, Constanze Wiek, Helmut Hanenberg, Anja Stefanski, Kai Stühler, Björn Stork

Sci Rep. 2021; 11: 13863. Published online 2021 Jul 5. doi: 10.1038/s41598-021-92408-4

PMCID:: PMC8257712

Abstract Article PDF–3.2M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 764241112.

Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes

Yasir Mohamud, Junyan Shi, Hui Tang, Pinhao Xiang, Yuan Chao Xue, Huitao Liu, Chen Seng Ng, Honglin Luo

Sci Rep. 2020; 10: 19068. Published online 2020 Nov 4. doi: 10.1038/s41598-020-76227-7

PMCID:: PMC7642411

Abstract Article PDF–4.7M

Select item 761025813.

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

Tiffany Tsang, Jessica M. Posimo, Andrea A. Gudiel, Michelle Cicchini, David M. Feldser, Donita C. Brady

Nat Cell Biol. Author manuscript; available in PMC 2020 Nov 4.

Published in final edited form as: Nat Cell Biol. 2020 Apr; 22(4): 412–424. Published online 2020 Mar 16. doi: 10.1038/s41556-020-0481-4

PMCID:: PMC7610258

Abstract Article PDF–5.2M

Select item 756688114.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 741139015.

Long non-coding RNA growth arrest-specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer

Guangping Li, Lin Qian, Xiaoqin Tang, Yuan Chen, Ziyi Zhao, Cuiwei Zhang

Mol Med Rep. 2020 Sep; 22(3): 2460–2468. Published online 2020 Jul 10. doi: 10.3892/mmr.2020.11334

PMCID:: PMC7411390

Abstract Article PDF–1.4M

Select item 733749316.

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

Xiaoshan Shi, Adam L. Yokom, Chunxin Wang, Lindsey N. Young, Richard J. Youle, James H. Hurley

J Cell Biol. 2020 Jul 6; 219(7): e201911047. Published online 2020 Jun 9. doi: 10.1083/jcb.201911047

PMCID:: PMC7337493

Abstract Article PDF–5.5M

Select item 677813717.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 644186818.

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1

Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu

EBioMedicine. 2019 Mar; 41: 320–332. Published online 2019 Feb 7. doi: 10.1016/j.ebiom.2019.01.058

PMCID:: PMC6441868

Abstract Article PDF–7.0M

Select item 637820019.

LncRNA DUXAP9‐206 directly binds with Cbl‐b to augment EGFR signaling and promotes non‐small cell lung cancer progression

Ting Zhu, Shu An, Man‐Ting Choy, Junhao Zhou, Shanshan Wu, Shihua Liu, Bangdong Liu, Zhicheng Yao, Xun Zhu, Jueheng Wu, Zhenjian He

J Cell Mol Med. 2019 Mar; 23(3): 1852–1864. Published online 2018 Dec 4. doi: 10.1111/jcmm.14085

Correction in:: J Cell Mol Med. 2022 Apr; 26(7): 2137.

PMCID:: PMC6378200

Abstract Article PDF–8.1M

Select item 569971020.

Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9

Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy

Cell Rep. Author manuscript; available in PMC 2017 Nov 22.

Published in final edited form as: Cell Rep. 2017 Sep 5; 20(10): 2341–2356. doi: 10.1016/j.celrep.2017.08.034

PMCID:: PMC5699710

Abstract Article PDF–2.6M

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