PMC Links for GEO Profiles (Select 106187272) - PMC

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75470214.

The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress

Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Müller

Nat Commun. 2020; 11: 5117. Published online 2020 Oct 9. doi: 10.1038/s41467-020-18857-z

PMCID:: PMC7547021

Abstract Article PDF–5.6M

Select item 68157715.

ALPK1 regulates streptozotocin‐induced nephropathy through CCL2 and CCL5 expressions

Chi‐Pin Lee, Srinivasan Nithiyanantham, Hui‐Ting Hsu, Kun‐Tu Yeh, Tzer‐Min Kuo, Ying‐Chin Ko

J Cell Mol Med. 2019 Nov; 23(11): 7699–7708. Published online 2019 Sep 26. doi: 10.1111/jcmm.14643

PMCID:: PMC6815771

Abstract Article PDF–2.0M

Select item 67524786.

ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder

Lloyd B. Williams, Asif Javed, Amin Sabri, Denise J. Morgan, Chad D. Huff, John R. Grigg, Xiu Ting Heng, Alexis J. Khng, Iris H. I. M. Hollink, Margaux A. Morrison, Leah A. Owen, Katherine Anderson, Krista Kinard, Rebecca Greenlees, Danica Novacic, H. Nida Sen, Wadih M. Zein, George M. Rodgers, Albert T. Vitale, Neena B. Haider, Axel M. Hillmer, Pauline C. Ng, Shankaracharya, Anson Cheng, Linda Zheng, Mark C. Gillies, Marjon van Slegtenhorst, P. Martin van Hagen, Tom O. A. R. Missotten, Gary L. Farley, Michael Polo, James Malatack, Julie Curtin, Frank Martin, Susan Arbuckle, Stephen I. Alexander, Megan Chircop, Sonia Davila, Kathleen B. Digre, Robyn V. Jamieson, Margaret M. DeAngelis

Genet Med. 2019; 21(9): 2103–2115. Published online 2019 Apr 10. doi: 10.1038/s41436-019-0476-3

PMCID:: PMC6752478

Abstract Article PDF–3.7M

Select item 65252467.

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma

Mamunur Rashid, Michiel van der Horst, Thomas Mentzel, Francesca Butera, Ingrid Ferreira, Alena Pance, Arno Rütten, Bostjan Luzar, Zlatko Marusic, Nicolas de Saint Aubain, Jennifer S. Ko, Steven D. Billings, Sofia Chen, Marie Abi Daoud, James Hewinson, Sandra Louzada, Paul W. Harms, Guia Cerretelli, Carla Daniela Robles-Espinoza, Rajiv M. Patel, Louise van der Weyden, Chris Bakal, Jason L. Hornick, Mark J. Arends, Thomas Brenn, David J. Adams

Nat Commun. 2019; 10: 2213. Published online 2019 May 17. doi: 10.1038/s41467-019-09979-0

PMCID:: PMC6525246

Abstract Article PDF–1.6M

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 53477699.

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer

Juliane Strietz, Stella S. Stepputtis, Bogdan-Tiberius Preca, Corinne Vannier, Mihee M. Kim, David J. Castro, Qingyan Au, Melanie Boerries, Hauke Busch, Pedro Aza-Blanc, Susanne Heynen-Genel, Peter Bronsert, Bernhard Kuster, Elmar Stickeler, Thomas Brabletz, Robert G. Oshima, Jochen Maurer

Oncotarget. 2016 Dec 13; 7(50): 83278–83293. Published online 2016 Nov 4. doi: 10.18632/oncotarget.13086

PMCID:: PMC5347769

Abstract Article PDF–5.1M

Select item 533630810.

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cécile Arrieumerlou

PLoS Pathog. 2017 Feb; 13(2): e1006224. Published online 2017 Feb 21. doi: 10.1371/journal.ppat.1006224

PMCID:: PMC5336308

Abstract Article PDF–3.1M

Select item 490129911.

Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers

Hsien-Feng Liao, Hsien-Hsiung Lee, Ya-Sian Chang, Chia-Li Lin, Ting-Yuan Liu, Yu-Chia Chen, Ju-Chen Yen, Ya-Ting Lee, Chien-Yu Lin, Shih-Hsiung Wu, Ying-Chin Ko, Jan-Gowth Chang

Sci Rep. 2016; 6: 27350. Published online 2016 Jun 10. doi: 10.1038/srep27350

PMCID:: PMC4901299

Abstract Article PDF–1.7M

Select item 486442412.

ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares

Chi-Pin Lee, Shang-Lun Chiang, Albert Min-Shan Ko, Yu-Fan Liu, Che Ma, Chi-Yu Lu, Chung-Ming Huang, Jan-Gowth Chang, Tzer-Min Kuo, Chia-Lin Chen, Eing-Mei Tsai, Ying-Chin Ko

Sci Rep. 2016; 6: 25740. Published online 2016 May 12. doi: 10.1038/srep25740

Correction in:: Sci Rep. 2016; 6: 27323.

PMCID:: PMC4864424

Abstract Article PDF–2.0M

Select item 476457313.

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich

eLife. 2015; 4: e11466. Published online 2015 Dec 17. doi: 10.7554/eLife.11466

PMCID:: PMC4764573

Abstract Article PDF–5.7M

Select item 461721114.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 428613115.

Common variant of ALPK1 is not associated with gout: a replication study

Toshinori Chiba, Hirotaka Matsuo, Masayuki Sakiyama, Akiyoshi Nakayama, Seiko Shimizu, Kenji Wakai, Shino Suma, Hiroshi Nakashima, Yutaka Sakurai, Toru Shimizu, Kimiyoshi Ichida, Nariyoshi Shinomiya

Hum Cell. 2015; 28(1): 1–4. Published online 2014 Oct 19. doi: 10.1007/s13577-014-0103-1

PMCID:: PMC4286131

Abstract Article PDF–203K

Select item 389478616.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 369559617.

ALPK1 genetic regulation and risk in relation to gout

Albert Min-Shan Ko, Hung-Pin Tu, Tze-Tze Liu, Jan-Gowth Chang, Chung-Yee Yuo, Shang-Lun Chiang, Shun-Jen Chang, Yu-Fan Liu, Allen Min-Jen Ko, Chien-Hung Lee, Chi-Pin Lee, Chung-Ming Chang, Shih-Feng Tsai, Ying-Chin Ko

Int J Epidemiol. 2013 Apr; 42(2): 466–474. Published online 2013 Apr 5. doi: 10.1093/ije/dyt028

PMCID:: PMC3695596

Abstract Article PDF–528K

Select item 338606918.

Functional genomics identifies therapeutic targets for MYC-driven cancer

Masafumi Toyoshima, Heather L. Howie, Maki Imakura, Ryan M. Walsh, James E. Annis, Aaron N. Chang, Jason Frazier, B. Nelson Chau, Andrey Loboda, Peter S. Linsley, Michele A. Cleary, Julie R. Park, Carla Grandori

Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24): 9545–9550. Published online 2012 May 23. doi: 10.1073/pnas.1121119109

PMCID:: PMC3386069

Abstract Article PDF–940K

Select item 337010019.

A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P. Bradfield, H. Rob Taal, Nicholas J. Timpson, André Scherag, Cecile Lecoeur, Nicole M. Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, Rany M. Salem, Fredrick R. Schumacher, Diana L. Cousminer, Patrick M.A. Sleiman, Jianhua Zhao, Robert I. Berkowitz, Karani S. Vimaleswaran, Ivonne Jarick, Craig E. Pennell, David M. Evans, Beate St. Pourcain, Diane J. Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeinera, André G. Uitterlinden, Cornelia M. van Duijn, Ralf J.P. van der Valk, Johan C. de Jongste, Dirkje S. Postma, Dorret I. Boomsma, William J. Gauderman, Mohamed T. Hassanein, Cecilia M. Lindgren, Reedik Mägi, Colin A.G. Boreham, Charlotte E. Neville, Luis A. Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, Johan G. Eriksson, Aarno Palotie, Jean Dallongeville, Shikta Das, Panos Deloukas, George McMahon, Susan M. Ring, John P. Kemp, Jessica L. Buxton, Alexandra I.F. Blakemore, Mariona Bustamante, Mònica Guxens, Joel N. Hirschhorn, Matthew W. Gillman, Eskil Kreiner-Møller, Hans Bisgaard, Frank D. Gilliland, Joachim Heinrich, Eleanor Wheeler, Inês Barroso, Stephen O'Rahilly, Aline Meirhaeghe, Thorkild I.A. Sørensen, Chris Power, Lyle J. Palmer, Anke Hinney, Elisabeth Widen, I. Sadaf Farooqi, Mark I. McCarthy, Philippe Froguel, David Meyre, Johannes Hebebrand, Marjo-Riitta Jarvelin, Vincent W.V. Jaddoe, George Davey Smith, Hakon Hakonarson, Struan F.A. Grant, for the Early Growth Genetics (EGG) Consortium

Nat Genet. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Nat Genet. 2012 May; 44(5): 526–531. doi: 10.1038/ng.2247

PMCID:: PMC3370100

Abstract Article PDF–247K

Select item 322964120.

Image-Based Genome-Wide siRNA Screen Identifies Selective Autophagy Factors

Anthony Orvedahl, Rhea Sumpter, Jr., Guanghua Xiao, Aylwin Ng, Zhongju Zou, Yi Tang, Masahiro Narimatsu, Christopher Gilpin, Qihua Sun, Michael Roth, Christian V. Forst, Jeffrey L. Wrana, Ying E. Zhang, Katherine Luby-Phelps, Ramnik Xavier, Yang Xie, Beth Levine

Nature. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Nature. 2011 Dec 1; 480(7375): 113–117. doi: 10.1038/nature10546

PMCID:: PMC3229641

Abstract Article PDF–2.3M

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