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Select item 83802141.

GABA_A receptors: structure, function, pharmacology, and related disorders

Amr Ghit, Dina Assal, Ahmed S. Al-Shami, Diaa Eldin E. Hussein

J Genet Eng Biotechnol. 2021 Dec; 19: 123. Published online 2021 Aug 21. doi: 10.1186/s43141-021-00224-0

PMCID:: PMC8380214

Abstract Article PDF–1016K

Select item 82568842.

Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA_A Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone

Allison L. Germann, Spencer R. Pierce, Hiroki Tateiwa, Yusuke Sugasawa, David E. Reichert, Alex S. Evers, Joe Henry Steinbach, Gustav Akk

Mol Pharmacol. 2021 Jul; 100(1): 19–31. Published online 2021 Jul. doi: 10.1124/molpharm.121.000268

PMCID:: PMC8256884

Abstract Article PDF–1.7M

Select item 67926113.

Segregation of Different GABA_A Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells

Zoltan Nusser, Werner Sieghart, Peter Somogyi

J Neurosci. 1998 Mar 1; 18(5): 1693–1703. doi: 10.1523/JNEUROSCI.18-05-01693.1998

PMCID:: PMC6792611

Abstract Article PDF–1.4M

Select item 67575804.

Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins

Jun Kitano, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto, Yoshiaki Nakajima, Shigetada Nakanishi

J Neurosci. 2002 Feb 15; 22(4): 1280–1289. doi: 10.1523/JNEUROSCI.22-04-01280.2002

PMCID:: PMC6757580

Abstract Article PDF–529K

Select item 67303735.

Mutation of Glutamate 155 of the GABA_A Receptor β₂ Subunit Produces a Spontaneously Open Channel: A Trigger for Channel Activation

J. Glen Newell, Ross A. McDevitt, Cynthia Czajkowski

J Neurosci. 2004 Dec 15; 24(50): 11226–11235. doi: 10.1523/JNEUROSCI.3746-04.2004

PMCID:: PMC6730373

Abstract Article PDF–528K

Select item 67297126.

Slow Actions of Neuroactive Steroids at GABA_A Receptors

Hong-Jin Shu, Lawrence N. Eisenman, Deepani Jinadasa, Douglas F. Covey, Charles F. Zorumski, Steven Mennerick

J Neurosci. 2004 Jul 28; 24(30): 6667–6675. doi: 10.1523/JNEUROSCI.1399-04.2004

PMCID:: PMC6729712

Abstract Article PDF–268K

Select item 62207087.

Structure of a human synaptic GABA-A receptor

Shaotong Zhu, Colleen M. Noviello, Jinfeng Teng, Richard M. Walsh, Jr., Jeong Joo Kim, Ryan E. Hibbs

Nature. Author manuscript; available in PMC 2018 Dec 27.

Published in final edited form as: Nature. 2018 Jul; 559(7712): 67–72. Published online 2018 Jun 27. doi: 10.1038/s41586-018-0255-3

PMCID:: PMC6220708

Abstract Article PDF–6.8M

Select item 60892398.

The GABA_A receptor β subunit is required for inhibitory transmission

Quynh-Anh Nguyen, Roger A. Nicoll

Neuron. Author manuscript; available in PMC 2019 May 16.

Published in final edited form as: Neuron. 2018 May 16; 98(4): 718–725.e3. Published online 2018 Apr 26. doi: 10.1016/j.neuron.2018.03.046

PMCID:: PMC6089239

Abstract Article PDF–779K

Select item 53844239.

A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy

Atsushi Ishii, Jing-Qiong Kang, Cara C Schornak, Ciria C Hernandez, Wangzhen Shen, Joseph C Watkins, Robert L Macdonald, Shinichi Hirose

J Med Genet. 2017 Mar; 54(3): 202–211. Published online 2016 Oct 27. doi: 10.1136/jmedgenet-2016-104083

PMCID:: PMC5384423

Abstract Article PDF–5.7M

Select item 534747310.

GARLH family proteins stabilize GABA_A receptors at synapses

Tokiwa Yamasaki, Erika Hoyos-Ramirez, James S. Martenson, Megumi Morimoto-Tomita, Susumu Tomita

Neuron. Author manuscript; available in PMC 2018 Mar 8.

Published in final edited form as: Neuron. 2017 Mar 8; 93(5): 1138–1152.e6. doi: 10.1016/j.neuron.2017.02.023

PMCID:: PMC5347473

Abstract Article PDF–2.3M

Select item 500009211.

Toward Understanding Functional Properties and Subunit Arrangement of α₄β₂δ γ-Aminobutyric Acid, Type A (GABA_A) Receptors

Nisa Wongsamitkul, Roland Baur, Erwin Sigel

J Biol Chem. 2016 Aug 26; 291(35): 18474–18483. Published online 2016 Jul 5. doi: 10.1074/jbc.M116.738906

PMCID:: PMC5000092

Abstract Article PDF–1.7M

Select item 493315412.

γ-Aminobutyric Acid Type A (GABA_A) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains

Laura E. Brown, Martin W. Nicholson, Jessica E. Arama, Audrey Mercer, Alex M. Thomson, Jasmina N. Jovanovic

J Biol Chem. 2016 Jul 1; 291(27): 13926–13942. Published online 2016 Apr 20. doi: 10.1074/jbc.M116.714790

PMCID:: PMC4933154

Abstract Article PDF–3.1M

Select item 469689113.

Flumazenil decreases surface expression of α4β2δ GABA_A receptors by increasing the rate of receptor internalization

Aarti Kuver, Sheryl S. Smith

Brain Res Bull. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Brain Res Bull. 2016 Jan; 120: 131–143. Published online 2015 Nov 22. doi: 10.1016/j.brainresbull.2015.11.015

PMCID:: PMC4696891

Abstract Article PDF–993K

Select item 451830114.

Interneuron- and GABA_A receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells

Qionger He, Ian Duguid, Beverley Clark, Patrizia Panzanelli, Bijal Patel, Philip Thomas, Jean-Marc Fritschy, Trevor G. Smart

Nat Commun. 2015; 6: 7364. Published online 2015 Jul 16. doi: 10.1038/ncomms8364

PMCID:: PMC4518301

Abstract Article PDF–3.9M

Select item 435409815.

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABA_A Receptors

Laura E. Brown, Celine Fuchs, Martin W. Nicholson, F. Anne Stephenson, Alex M. Thomson, Jasmina N. Jovanovic

J Vis Exp. 2014; (93): 52115. Published online 2014 Nov 14. doi: 10.3791/52115

PMCID:: PMC4354098

Abstract Article PDF–1.0M

Select item 402898616.

GABA_A receptors can initiate the formation of functional inhibitory GABAergic synapses

Celine Fuchs, Karine Abitbol, Jemima J Burden, Audrey Mercer, Laura Brown, Jonathan Iball, F Anne Stephenson, Alex M Thomson, Jasmina N Jovanovic

Eur J Neurosci. 2013 Oct; 38(8): 3146–3158. Published online 2013 Aug 5. doi: 10.1111/ejn.12331

PMCID:: PMC4028986

Abstract Article PDF–3.8M

Select item 334016017.

The Cell Adhesion Molecule Neuroplastin-65 Is a Novel Interaction Partner of γ-Aminobutyric Acid Type A Receptors

Isabella Sarto-Jackson, Ivan Milenkovic, Karl-Heinz Smalla, Eckart D. Gundelfinger, Thilo Kaehne, Rodrigo Herrera-Molina, Sabine Thomas, Michael A. Kiebler, Werner Sieghart

J Biol Chem. 2012 Apr 20; 287(17): 14201–14214. Published online 2012 Mar 2. doi: 10.1074/jbc.M111.293175

PMCID:: PMC3340160

Abstract Article PDF–1.5M

Select item 331451418.

GISP binding to TSG101 increases GABA_B receptor stability by down-regulating ESCRT-mediated lysosomal degradation

Sriharsha Kantamneni, David Holman, Kevin A. Wilkinson, Sônia A. L. Corrêa, Marco Feligioni, Simon Ogden, William Fraser, Atsushi Nishimune, Jeremy M. Henley

J Neurochem. Author manuscript; available in PMC 2012 Mar 28.

Published in final edited form as: J Neurochem. 2008 Oct; 107(1): 86–95. Published online 2008 Jul 17. doi: 10.1111/j.1471-4159.2008.05580.x