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Select item 58202971.

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner

Nat Commun. 2018; 9: 728. Published online 2018 Feb 20. doi: 10.1038/s41467-018-03135-w

PMCID:: PMC5820297

Abstract Article PDF–5.5M

Select item 48421082.

Ligase-4 deficiency causes distinctive immune abnormalities in asymptomatic individuals

Kerstin Felgentreff, Sachin N. Baxi, Yu Nee Lee, Kerry Dobbs, Lauren A. Henderson, Krisztian Csomos, Erdyni N. Tsitsikov, Mary Armanios, Jolan E. Walter, Luigi D. Notarangelo

J Clin Immunol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: J Clin Immunol. 2016 May; 36(4): 341–353. Published online 2016 Apr 11. doi: 10.1007/s10875-016-0266-5

PMCID:: PMC4842108

Abstract Article PDF–1.6M

Select item 44231913.

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

A Craxton, J Somers, D Munnur, R Jukes-Jones, K Cain, M Malewicz

Cell Death Differ. 2015 Jun; 22(6): 890–897. Published online 2015 Mar 13. doi: 10.1038/cdd.2015.22

PMCID:: PMC4423191

Abstract Article PDF–1.9M

Select item 41255354.

DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

Sehyun Oh, Adam Harvey, Jacob Zimbric, Yongbao Wang, Thanh Nguyen, Pauline J. Jackson, Eric A. Hendrickson

DNA Repair (Amst) Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2014 Sep; 21: 97–110. Published online 2014 May 16. doi: 10.1016/j.dnarep.2014.04.015

PMCID:: PMC4125535

Abstract Article PDF–991K

Select item 36558435.

Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility

Peng Zhao, Peng Zou, Lin Zhao, Wei Yan, Chunsheng Kang, Tao Jiang, Yongping You

BMC Cancer. 2013; 13: 234. Published online 2013 May 10. doi: 10.1186/1471-2407-13-234

PMCID:: PMC3655843

Abstract Article PDF–195K

Select item 35619726.

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction

Sehyun Oh, Yongbao Wang, Jacob Zimbric, Eric A. Hendrickson

Nucleic Acids Res. 2013 Feb; 41(3): 1734–1749. Published online 2012 Dec 26. doi: 10.1093/nar/gks1326

PMCID:: PMC3561972

Abstract Article PDF–3.6M

Select item 33744107.

A High-Throughput Scintillation Proximity-Based Assay for Human DNA Ligase IV

Hui-Min Tseng, David Shum, Bhavneet Bhinder, Sindy Escobar, Nicholas J. Veomett, Alan E. Tomkinson, David Y. Gin, Hakim Djaballah, David A. Scheinberg

Assay Drug Dev Technol. 2012 Jun; 10(3): 235–249. doi: 10.1089/adt.2011.0404

PMCID:: PMC3374410

Abstract Article PDF–701K

Select item 31780598.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 30794299.

DNA Ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

Yankun Gao, Sachin Katyal, Youngsoo Lee, Jingfeng Zhao, Jerold E. Rehg, Helen R. Russell, Peter J. McKinnon

Nature. Author manuscript; available in PMC 2011 Sep 10.

Published in final edited form as: Nature. 2011 Mar 10; 471(7337): 240–244. doi: 10.1038/nature09773

PMCID:: PMC3079429

Abstract Article PDF–2.6M

Select item 307930810.

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway

Michael R. Lieber

Annu Rev Biochem. Author manuscript; available in PMC 2011 Apr 19.

Published in final edited form as: Annu Rev Biochem. 2010; 79: 181–211. doi: 10.1146/annurev.biochem.052308.093131

PMCID:: PMC3079308

Abstract Article PDF–754K

Select item 285909911.

Ku is a 5'dRP/AP lyase that excises nucleotide damage near broken ends

Steven A. Roberts, Natasha Strande, Martin D. Burkhalter, Christina Strom, Jody M. Havener, Paul Hasty, Dale A. Ramsden

Nature. Author manuscript; available in PMC 2010 Oct 22.

Published in final edited form as: Nature. 2010 Apr 22; 464(7292): 1214–1217. Published online 2010 Apr 11. doi: 10.1038/nature08926

PMCID:: PMC2859099

Abstract Article PDF–407K

Select item 284030712.

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

Francesca Rucci, Luigi D. Notarangelo, Alex Fazeli, Laura Patrizi, Thomas Hickernell, Tiziana Paganini, Kristen M. Coakley, Cynthia Detre, Marton Keszei, Jolan E. Walter, Lauren Feldman, Hwei-Ling Cheng, Pietro Luigi Poliani, Jing H. Wang, Barbara B. Balter, Mike Recher, Emma-Maria Andersson, Shan Zha, Silvia Giliani, Cox Terhorst, Frederick W. Alt, Catherine T. Yan

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 3024–3029. Published online 2010 Feb 1. doi: 10.1073/pnas.0914865107

PMCID:: PMC2840307

Abstract Article PDF–946K

Select item 273451113.

Distinct kinetics of human DNA ligases I, IIIα, IIIβ, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair

Xi Chen, Jeff D. Ballin, Julie Della-Maria, Miaw-Sheue Tsai, Elizabeth J. White, Alan E. Tomkinson, Gerald M. Wilson

DNA Repair (Amst) Author manuscript; available in PMC 2010 Aug 6.

Published in final edited form as: DNA Repair (Amst). 2009 Aug 6; 8(8): 961–968. Published online 2009 Jul 8. doi: 10.1016/j.dnarep.2009.06.002

PMCID:: PMC2734511

Abstract Article PDF–2.3M

Select item 268912614.

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome

Anastasia Nijnik, Sara Dawson, Tanya L. Crockford, Lisa Woodbine, Supawan Visetnoi, Sophia Bennett, Margaret Jones, Gareth D. Turner, Penelope A. Jeggo, Christopher C. Goodnow, Richard J. Cornall

J Clin Invest. 2009 Jun 1; 119(6): 1696–1705. Published online 2009 May 18. doi: 10.1172/JCI32743

PMCID:: PMC2689126

Abstract Article PDF–1.7M

Select item 262914415.

DNA Repair Gene Polymorphisms and Risk of Pancreatic Cancer

Donghui Li, Hideo Suzuki, Bingrong Liu, Jeffrey Morris, Jun Liu, Taro Okazaki, Yanan Li, Ping Chang, James L. Abbruzzese

Clin Cancer Res. Author manuscript; available in PMC 2010 Jan 15.

Published in final edited form as: Clin Cancer Res. 2009 Jan 15; 15(2): 740–746. doi: 10.1158/1078-0432.CCR-08-1607

PMCID:: PMC2629144

Abstract Article PDF–314K

Select item 175722016.

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

P Roddam, S Rollinson, M O'Driscoll, P Jeggo, A Jack, G Morgan

J Med Genet. 2002 Dec; 39(12): 900–905. doi: 10.1136/jmg.39.12.900

PMCID:: PMC1757220

Summary PDF–199K

Select item 150249817.

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Kenji E. Orii, Youngsoo Lee, Naomi Kondo, Peter J. McKinnon

Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26): 10017–10022. Published online 2006 Jun 15. doi: 10.1073/pnas.0602436103

PMCID:: PMC1502498

Abstract Article PDF–3.0M

Select item 42035418.

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

Kevin D. Mills, David O. Ferguson, Jeroen Essers, Mark Eckersdorff, Roland Kanaar, Frederick W. Alt

Genes Dev. 2004 Jun 1; 18(11): 1283–1292. doi: 10.1101/gad.1204304

PMCID:: PMC420354

Abstract Article PDF–194K

Select item 15000119.

In Vitro and In Vivo Interactions of DNA Ligase IV with a Subunit of the Condensin Complex

Marcin R. Przewloka, Paige E. Pardington, Steven M. Yannone, David J. Chen, Robert B. Cary

Mol Biol Cell. 2003 Feb; 14(2): 685–697. doi: 10.1091/mbc.E01-11-0117

PMCID:: PMC150001

Abstract Article PDF–737K

Select item 3063820.

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

JoAnn Sekiguchi, David O. Ferguson, Hua Tang Chen, Eva Mary Yang, John Earle, Karen Frank, Scott Whitlow, Yansong Gu, Yang Xu, André Nussenzweig, Frederick W. Alt

Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6): 3243–3248. Published online 2001 Mar 6. doi: 10.1073/pnas.051632098

PMCID:: PMC30638

Abstract Article PDF–1.0M

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