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Select item 111591881.

Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor down‐regulation during the tumor promotion process from the early stage in a rat two‐stage hepatocarcinogenesis model

Eriko Taniai, Masaomi Kawai, Yasuaki Dewa, Jihei Nishimura, Tomoaki Harada, Yukie Saegusa, Sayaka Matsumoto, Miwa Takahashi, Kunitoshi Mitsumori, Makoto Shibutani

Cancer Sci. 2009 May; 100(5): 813–820. Published online 2009 Mar 20. doi: 10.1111/j.1349-7006.2009.01120.x

PMCID:: PMC11159188

Abstract Article PDF–3.9M

Select item 66722992.

Nonredundant Role of Akt2 for Neuroprotection of Rod Photoreceptor Cells from Light-Induced Cell Death

Guiyuan Li, Robert E. Anderson, Hiroshi Tomita, Ruben Adler, Xiaochun Liu, Donald J. Zack, Raju V. S. Rajala

J Neurosci. 2007 Jan 3; 27(1): 203–211. doi: 10.1523/JNEUROSCI.0445-06.2007

PMCID:: PMC6672299

Abstract Article PDF–899K

Select item 62393043.

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression

Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S. Kasinath, Goutam Ghosh Choudhury

PLoS One. 2018; 13(11): e0207285. Published online 2018 Nov 16. doi: 10.1371/journal.pone.0207285

PMCID:: PMC6239304

Abstract Article PDF–3.4M

Select item 53483564.

Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment

Jia Song, Qian Liu, Han Tang, Aibin Tao, Hao Wang, Raymond Kao, Tao Rui

Oncotarget. 2016 Dec 6; 7(49): 80803–80810. Published online 2016 Nov 4. doi: 10.18632/oncotarget.13096

PMCID:: PMC5348356

Abstract Article PDF–2.3M

Select item 53397615.

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice

Sally Yu Shi, Cynthia T. Luk, Stephanie A. Schroer, Min Jeong Kim, David W. Dodington, Tharini Sivasubramaniyam, Lauren Lin, Erica P. Cai, Shun-Yan Lu, Kay-Uwe Wagner, Richard P. Bazinet, Minna Woo

J Biol Chem. 2017 Mar 3; 292(9): 3789–3799. Published online 2017 Jan 18. doi: 10.1074/jbc.M116.752519

PMCID:: PMC5339761

Abstract Article PDF–1.6M

Select item 52286186.

Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle

Naveen Sharma, Edward B. Arias, Gregory D. Cartee

Appl Physiol Nutr Metab. Author manuscript; available in PMC 2017 Jan 12.

Published in final edited form as: Appl Physiol Nutr Metab. 2016 Nov; 41(11): 1208–1211. Published online 2016 Aug 16. doi: 10.1139/apnm-2016-0326

PMCID:: PMC5228618

Abstract Article PDF–504K

Select item 47967407.

Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats

Haiyan Wang, Edward B. Arias, Gregory D. Cartee

Am J Physiol Regul Integr Comp Physiol. 2016 Mar 1; 310(5): R449–R458. Published online 2016 Jan 6. doi: 10.1152/ajpregu.00449.2015

PMCID:: PMC4796740

Abstract Article

Select item 41515248.

Akt1 and Akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

Rachelle L. Dillon, Richard Marcotte, Bryan T. Hennessy, James R. Woodgett, Gordon B. Mills, William J. Muller

Cancer Res. Author manuscript; available in PMC 2014 Sep 2.

Published in final edited form as: Cancer Res. 2009 Jun 15; 69(12): 5057–5064. Published online 2009 Jun 2. doi: 10.1158/0008-5472.CAN-08-4287

PMCID:: PMC4151524

Abstract Article PDF–2.1M

Select item 41254649.

PTEN-DEFICIENT TUMORS DEPEND ON AKT2 FOR MAINTENANCE AND SURVIVAL

Y. Rebecca Chin, Xin Yuan, Steven P. Balk, Alex Toker

Cancer Discov. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Cancer Discov. 2014 Aug; 4(8): 942–955. Published online 2014 May 16. doi: 10.1158/2159-8290.CD-13-0873

PMCID:: PMC4125464

Abstract Article PDF–1.4M

Select item 402942310.

Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

N. Temofonte, M. P. Sajan, S. Nimal, T. Pastoor, C. Fumero, L. Casaubon, J. L. Powe, M. L. Standaert, R. V. Farese

Diabetologia. Author manuscript; available in PMC 2014 May 21.

Published in final edited form as: Diabetologia. 2009 Jan; 52(1): 60–64. Published online 2008 Oct 30. doi: 10.1007/s00125-008-1180-z

PMCID:: PMC4029423

Abstract Article PDF–996K

Select item 383877911.

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

Thomas Galbo, Rachel J. Perry, Erica Nishimura, Varman T. Samuel, Bjørn Quistorff, Gerald I. Shulman

Aging (Albany NY) 2013 Oct; 5(10): 770–781. Published online 2013 Oct 21. doi: 10.18632/aging.100611

PMCID:: PMC3838779

Abstract Article PDF–2.0M

Select item 373473412.

Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue

L M Berends, D S Fernandez-Twinn, M S Martin-Gronert, R L Cripps, S E Ozanne

Int J Obes (Lond) 2013 Aug; 37(8): 1051–1057. Published online 2012 Dec 11. doi: 10.1038/ijo.2012.196

PMCID:: PMC3734734

Abstract Article PDF–1.0M

Select item 352610113.

Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes

Li-E Wang, Hongxia Ma, Katherine S. Hale, Ming Yin, Larissa A. Meyer, Hongliang Liu, Jie Li, Karen H. Lu, Bryan T. Hennessy, Xuesong Li, Margaret R. Spitz, Qingyi Wei, Gordon B. Mills

J Cancer Res Clin Oncol. Author manuscript; available in PMC 2012 Dec 19.

Published in final edited form as: J Cancer Res Clin Oncol. 2012 Mar; 138(3): 377–385. Published online 2011 Dec 7. doi: 10.1007/s00432-011-1103-0

PMCID:: PMC3526101

Abstract Article PDF–522K

Select item 339989514.

Genetic Variations in a PTEN/AKT/mTOR Axis and Prostate Cancer Risk in a Chinese Population

Jiawei Chen, Pengfei Shao, Qiang Cao, Pu Li, Jie Li, Hongzhou Cai, Jian Zhu, Meilin Wang, Zhengdong Zhang, Chao Qin, Changjun Yin

PLoS One. 2012; 7(7): e40817. Published online 2012 Jul 18. doi: 10.1371/journal.pone.0040817

PMCID:: PMC3399895

Abstract Article PDF–111K

Select item 336866615.

Akt-Dependent and Isoform-Specific Regulation of Dopamine Transporter Cell Surface Expression

Nicole K. Speed, Heinrich J. G. Matthies, J. Phillip Kennedy, Roxanne A. Vaughan, Jonathan A. Javitch, Scott J. Russo, Craig W. Lindsley, Kevin Niswender, Aurelio Galli

ACS Chem Neurosci. 2010 Jul 21; 1(7): 476–481. Published online 2010 May 25. doi: 10.1021/cn100031t

PMCID:: PMC3368666

Abstract Article PDF–2.1M

Select item 327262516.

The effect Akt2 deletion on tumor development in Pten^+/− mice

P-Z Xu, M-L Chen, S-M Jeon, X-d Peng, N Hay

Oncogene. 2012 Jan 26; 31(4): 518–526. Published online 2011 Jul 11. doi: 10.1038/onc.2011.243

PMCID:: PMC3272625

Abstract Article PDF–1.2M

Select item 321915517.

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

Tung O. Chan, Jin Zhang, Ulrich Rodeck, John M. Pascal, Roger S. Armen, Maureen Spring, Calin D. Dumitru, Valerie Myers, Xue Li, Joseph Y. Cheung, Arthur M. Feldman

Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46): E1120-E1127. Published online 2011 Oct 26. doi: 10.1073/pnas.1109879108

PMCID:: PMC3219155

Abstract Article PDF–1.7M

Select item 320422118.

An Activating Mutation of AKT2 and Human Hypoglycemia

K. Hussain, B. Challis, N. Rocha, F. Payne, M. Minic, A. Thompson, A. Daly, C. Scott, J. Harris, B.J.L. Smillie, D.B. Savage, U. Ramaswami, P. De Lonlay, S. O’Rahilly, I. Barroso, R.K. Semple

Science. Author manuscript; available in PMC 2012 Apr 28.

Published in final edited form as: Science. 2011 Oct 28; 334(6055): 474. Published online 2011 Oct 6. doi: 10.1126/science.1210878

PMCID:: PMC3204221

Abstract Article PDF–575K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317257920.

C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane

Xiangyang Xie, Zhenwei Gong, Virginie Mansuy-Aubert, Qiong L. Zhou, Suren A. Tatulian, Daniel Sehrt, Florian Gnad, Laurence M. Brill, Khatereh Motamedchaboki, Yu Chen, Michael P. Czech, Matthias Mann, Marcus KrÜger, Zhen Y. Jiang

Cell Metab. Author manuscript; available in PMC 2012 Sep 7.

Published in final edited form as: Cell Metab. 2011 Sep 7; 14(3): 378–389. doi: 10.1016/j.cmet.2011.06.015