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Items: 1 to 20 of 368

1.
Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure
Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer
Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y
PMCID:
PMC11447256
AbstractArticlePDF–2.8M
2.
A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation
Arun Padmanabhan, Yvanka de Soysa, Angelo Pelonero, Valerie Sapp, Parisha P. Shah, Qiaohong Wang, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Tomohiro Nishino, Lin Ye, Rachel Yang, Ashley Karnay, Andrey Poleshko, Nikhita Bolar, Ricardo Linares-Saldana, Sanjeev S. Ranade, Michael Alexanian, Sarah U. Morton, Mohit Jain, Saptarsi M. Haldar, Deepak Srivastava, Rajan Jain
Nat Cardiovasc Res. Author manuscript; available in PMC 2024 Aug 29.
Published in final edited form as: Nat Cardiovasc Res. 2024 Mar; 3(3): 317–331. Published online 2024 Feb 23. doi: 10.1038/s44161-024-00431-1
PMCID:
PMC11361716
AbstractArticlePDF–8.1M
3.
SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition
Nieves Lara-Ureña, Elena Gómez-Marín, Isabel Pozuelo-Sánchez, José C. Reyes, Mario García-Domínguez
Cell Mol Life Sci. 2024 Dec; 81(1): 313. Published online 2024 Jul 27. doi: 10.1007/s00018-024-05343-8
PMCID:
PMC11335234
AbstractArticlePDF–7.8M
4.
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Fangyuan Chen, Shuyu Li, Min Liu, Cheng Qian, Zhiyin Shang, Xu Song, Wei Jiang, Chuantao Tu
Cell Mol Life Sci. 2024 Dec; 81(1): 295. Published online 2024 Jul 9. doi: 10.1007/s00018-024-05328-7
PMCID:
PMC11335218
AbstractArticlePDF–3.0M
5.
Interplay of condensation and chromatin binding underlies BRD4 targeting
Amy R. Strom, Jorine M. Eeftens, Yury Polyachenko, Claire J. Weaver, Hans-Frederick Watanabe, Dan Bracha, Natalia D. Orlovsky, Chanelle C. Jumper, William M. Jacobs, Clifford P. Brangwynne
Mol Biol Cell. 2024 Jun 1; 35(6): ar88. Published online 2024 May 21. doi: 10.1091/mbc.E24-01-0046
PMCID:
PMC11238092
AbstractArticlePDF–4.5M
6.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
7.
Bromodomain-containing protein 4 (BRD4): A key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics
Zonghui Ma, Andrew A. Bolinger, Jia Zhou, Bing Tian
Expert Opin Ther Targets. Author manuscript; available in PMC 2024 May 14.
Published in final edited form as: Expert Opin Ther Targets. 2023 Jan; 27(1): 1–7. Published online 2023 Feb 7. doi: 10.1080/14728222.2023.2175317
PMCID:
PMC11092387
AbstractArticlePDF–821K
8.
Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity
Xiaofang Xu, Dianhua Qiao, Allan R. Brasier
Front Immunol. 2024; 15: 1366235. Published online 2024 Mar 27. doi: 10.3389/fimmu.2024.1366235
PMCID:
PMC11004252
AbstractArticlePDF–8.6M
9.
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Felipe Andreiuolo, Christina K. Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J. Cimino, Martha Quezado, Kenneth Aldape
Acta Neuropathol Commun. 2024; 12: 42. Published online 2024 Mar 18. doi: 10.1186/s40478-024-01746-7
PMCID:
PMC10946093
AbstractArticlePDF–3.2M
10.
The P53–P21–RB1 pathway promotes BRD4 degradation in liver cancer through USP1
Neng Li, Erlei Zhang, Zhenyong Li, Suli Lv, Xuefeng Zhao, Qian Ke, Qingli Zou, Wensheng Li, Yifei Wang, Haocheng Guo, Tanjing Song, Lidong Sun
J Biol Chem. 2024 Mar; 300(3): 105707. Published online 2024 Feb 1. doi: 10.1016/j.jbc.2024.105707
PMCID:
PMC10907170
AbstractArticlePDF–2.0M
11.
p53 gain-of-function mutation induces metastasis via Brd4-dependent Csf-1 expression
Gizem Efe, Karen J. Dunbar, Kensuke Sugiura, Katherine Cunningham, Saul Carcamo, Spyros Karaiskos, Qiaosi Tang, Ricardo Cruz-Acuña, Lois Resnick-Silverman, Jessica Peura, Chao Lu, Dan Hasson, Andres J. Klein-Szanto, Alison M. Taylor, James J. Manfredi, Carol Prives, Anil K. Rustgi
Cancer Discov. Author manuscript; available in PMC 2024 Jun 12.
Published in final edited form as: Cancer Discov. 2023 Dec 12; 13(12): 2632–2651. doi: 10.1158/2159-8290.CD-23-0601
PMCID:
PMC10841313
AbstractArticlePDF–1.3M
12.
Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer
Shasha Li, Lulu Wang, Jing Shi, Yi Chen, Ang Xiao, Bingyue Huo, Wenjing Tian, Shilu Zhang, Gang Yang, Wensheng Gong, Huixia Zhang
PeerJ. 2024; 12: e16752. Published online 2024 Jan 10. doi: 10.7717/peerj.16752
PMCID:
PMC10787542
AbstractArticlePDF–13M
13.
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Calvin Yeager, Ronald D. Hill, Aanchal Dubey, Shwu-Yuan Wu, Cheng-Ming Chiang, Iain M. Morgan
J Virol. 2023 Oct; 97(10): e00782-23. Published online 2023 Sep 15. doi: 10.1128/jvi.00782-23
PMCID:
PMC10617519
AbstractArticlePDF–2.7M
14.
HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
Viacheslav M Morozov, Alberto Riva, Sadia Sarwar, Wan-Ju Kim, Jianping Li, Lei Zhou, Jonathan D Licht, Yehia Daaka, Alexander M Ishov
Nucleic Acids Res. 2023 Oct 27; 51(19): 10194–10217. Published online 2023 Aug 28. doi: 10.1093/nar/gkad700
PMCID:
PMC10602887
AbstractArticlePDF–3.9M
15.
JMJD6–BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells
Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
J Transl Med. 2023; 21: 752. Published online 2023 Oct 25. doi: 10.1186/s12967-023-04394-y
PMCID:
PMC10599021
AbstractArticlePDF–3.0M
16.
A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair–targeted therapy
Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye, Wen Liu, Han You
Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41): e2304534120. Published online 2023 Oct 2. doi: 10.1073/pnas.2304534120
PMCID:
PMC10576145
AbstractArticlePDF–2.6M
17.
Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
Donald P. Cameron, Jan Grosser, Swetlana Ladigan, Vladislav Kuzin, Evanthia Iliopoulou, Anika Wiegard, Hajar Benredjem, Kathryn Jackson, Sven T. Liffers, Smiths Lueong, Phyllis F. Cheung, Deepak Vangala, Michael Pohl, Richard Viebahn, Christian Teschendorf, Heiner Wolters, Selami Usta, Keyi Geng, Claudia Kutter, Marie Arsenian-Henriksson, Jens T. Siveke, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn, Laura Baranello
Sci Adv. 2023 Oct 13; 9(41): eadg5109. Published online 2023 Oct 13. doi: 10.1126/sciadv.adg5109
PMCID:
PMC10575591
AbstractArticlePDF–2.3M
18.
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Yi Liu, Hejing Liu, Miaomiao Ye, Mengying Jiang, Xin Chen, Gendi Song, Huihui Ji, Zhi-wei Wang, Xueqiong Zhu
Cell Death Dis. 2023 Sep; 14(9): 624. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06149-5
PMCID:
PMC10517134
AbstractArticlePDF–6.0M
19.
High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription
Annkatrin Bressin, Olga Jasnovidova, Mirjam Arnold, Elisabeth Altendorfer, Filip Trajkovski, Thomas A. Kratz, Joanna E. Handzlik, Denes Hnisz, Andreas Mayer
Nat Commun. 2023; 14: 4971. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40633-y
PMCID:
PMC10435483
AbstractArticlePDF–2.5M
20.
Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
Hua Yu, Tiezhu Shi, Linli Yao, Dongwei Xu, Yufeng Ding, Qiang Xia, Wei Liu, Xiongjun Wang
Cell Mol Immunol. 2023 Aug; 20(8): 867–880. Published online 2023 Jun 7. doi: 10.1038/s41423-023-01048-3
PMCID:
PMC10387471
AbstractArticlePDF–16M

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