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Select item 111793971.

HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model

Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui Li

BMC Musculoskelet Disord. 2024; 25: 467. Published online 2024 Jun 15. doi: 10.1186/s12891-024-07578-9

PMCID:: PMC11179397

Abstract Article PDF–11M

Select item 93814922.

HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway

Zhang Yuan, Liu Xiao-wei, Wei Juan, Liu Xiu-juan, Zhang Nian-yun, Sheng Lei

J Physiol Biochem. 2022; 78(3): 641–652. Published online 2022 Mar 22. doi: 10.1007/s13105-022-00884-7

PMCID:: PMC9381492

Abstract Article PDF–4.9M

Select item 93518293.

ATF4 Protects the Heart from Failure by Antagonizing Oxidative Stress

Xiaoding Wang, Guangyu Zhang, Subhajit Dasgupta, Erica L. Niewold, Chao Li, Qinfeng Li, Xiang Luo, Lin Tan, Anwarul Ferdous, Philip L. Lorenzi, Beverly A. Rothermel, Thomas G. Gillette, Christopher M. Adams, Philipp E. Scherer, Joseph A. Hill, Zhao V. Wang

Circ Res. Author manuscript; available in PMC 2023 Jun 24.

Published in final edited form as: Circ Res. 2022 Jun 24; 131(1): 91–105. Published online 2022 May 16. doi: 10.1161/CIRCRESAHA.122.321050

PMCID:: PMC9351829

Abstract Article PDF–3.2M

Select item 68855204.

PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes

Myong-Ho Jeong, Hyeon-Ju Jeong, Byeong-Yun Ahn, Jung-Hoon Pyun, Ilmin Kwon, Hana Cho, Jong-Sun Kang

Cell Death Dis. 2019 Dec; 10(12): 903. Published online 2019 Dec 2. doi: 10.1038/s41419-019-2147-3

Correction in:: Cell Death Dis. 2020 Mar; 11(3): 203.

PMCID:: PMC6885520

Abstract Article PDF–3.6M

Select item 67217525.

Parkin-Dependent Mitophagy Is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

Qi He, Zhenyu Li, Changchang Meng, Jingxian Wu, Yong Zhao, Jing Zhao

Cells. 2019 Aug; 8(8): 897. Published online 2019 Aug 14. doi: 10.3390/cells8080897

PMCID:: PMC6721752

Abstract Article PDF–5.4M

Select item 66718406.

Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior

Thomas A. Green, Imran N. Alibhai, Stephen Unterberg, Rachael L. Neve, Subroto Ghose, Carol A. Tamminga, Eric J. Nestler

J Neurosci. 2008 Feb 27; 28(9): 2025–2032. doi: 10.1523/JNEUROSCI.5273-07.2008

PMCID:: PMC6671840

Abstract Article PDF–453K

Select item 66349267.

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

Zohreh Galehdar, Patrick Swan, Benjamin Fuerth, Steven M. Callaghan, David S. Park, Sean P. Cregan

J Neurosci. 2010 Dec 15; 30(50): 16938–16948. doi: 10.1523/JNEUROSCI.1598-10.2010

PMCID:: PMC6634926

Abstract Article PDF–1.4M

Select item 65961538.

Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABA_BR Trafficking

Carlo Corona, Silvia Pasini, Jin Liu, Fatou Amar, Lloyd A. Greene, Michael L. Shelanski

J Neurosci. 2018 Jul 4; 38(27): 6102–6113. doi: 10.1523/JNEUROSCI.3350-17.2018

PMCID:: PMC6596153

Abstract Article PDF–3.5M

Select item 61510569.

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang, Zhenhua Zheng

J Neuroinflammation. 2018; 15: 275. Published online 2018 Sep 21. doi: 10.1186/s12974-018-1311-5

PMCID:: PMC6151056

Abstract Article PDF–6.6M

Select item 605276310.

Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson’s disease

Joseph C. Gully, Valeriy G. Sergeyev, Yogesh Bhootada, Hector Mendez-Gomez, Craig A. Meyers, Sergey Zolotukhin, Marina S. Gorbatyuk, Oleg S. Gorbatyuk

Neurosci Lett. Author manuscript; available in PMC 2018 Jul 19.

Published in final edited form as: Neurosci Lett. 2016 Aug 3; 627: 36–41. Published online 2016 May 24. doi: 10.1016/j.neulet.2016.05.039

PMCID:: PMC6052763

Abstract Article PDF–716K

Select item 571896111.

ATF4-induced metabolic reprograming is a synthetic vulnerability of the p62-deficient tumor stroma

Juan F. Linares, Thekla Cordes, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Christopher S. Ahn, Elias A. Castilla, Jorge Moscat, Christian M. Metallo, Maria T. Diaz-Meco

Cell Metab. Author manuscript; available in PMC 2018 Dec 5.

Published in final edited form as: Cell Metab. 2017 Dec 5; 26(6): 817–829.e6. Published online 2017 Oct 5. doi: 10.1016/j.cmet.2017.09.001

PMCID:: PMC5718961

Abstract Article PDF–2.9M

Select item 539267112.

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

Kimberly M. Alonge, Gordon P. Meares, F. Bradley Hillgartner

J Biol Chem. 2017 Mar 31; 292(13): 5239–5252. Published online 2017 Feb 10. doi: 10.1074/jbc.M116.762922

PMCID:: PMC5392671

Abstract Article PDF–2.2M

Select item 510790513.

Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα

Silvia Pasini, Jin Liu, Carlo Corona, Eugenie Peze-Heidsieck, Michael Shelanski, Lloyd A. Greene

Sci Rep. 2016; 6: 36952. Published online 2016 Nov 14. doi: 10.1038/srep36952

PMCID:: PMC5107905

Abstract Article PDF–1.6M

Select item 508560414.

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells

Masashi Masuda, Shinobu Miyazaki-Anzai, Audrey L. Keenan, Yuji Shiozaki, Kayo Okamura, Wallace S. Chick, Kristina Williams, Xiaoyun Zhao, Shaikh Mizanoor Rahman, Yin Tintut, Christopher M. Adams, Makoto Miyazaki

JCI Insight. 2016 Nov 3; 1(18): e88646. Published online 2016 Nov 3. doi: 10.1172/jci.insight.88646

PMCID:: PMC5085604

Abstract Article PDF–1.0M

Select item 436494815.

STAMP2 increases oxidative stress and is critical for prostate cancer

Yang Jin, Ling Wang, Su Qu, Xia Sheng, Alexandr Kristian, Gunhild M Mælandsmo, Nora Pällmann, Erkan Yuca, Ibrahim Tekedereli, Kivanc Gorgulu, Neslihan Alpay, Anil Sood, Gabriel Lopez-Berestein, Ladan Fazli, Paul Rennie, Bjørn Risberg, Håkon Wæhre, Håvard E Danielsen, Bulent Ozpolat, Fahri Saatcioglu

EMBO Mol Med. 2015 Mar; 7(3): 315–331. Published online 2015 Feb 13. doi: 10.15252/emmm.201404181

PMCID:: PMC4364948

Abstract Article PDF–1.5M

Select item 411811516.

Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib

Makoto Edagawa, Junya Kawauchi, Manabu Hirata, Hiroto Goshima, Makoto Inoue, Tatsuro Okamoto, Akira Murakami, Yoshihiko Maehara, Shigetaka Kitajima

J Biol Chem. 2014 Aug 1; 289(31): 21544–21561. Published online 2014 Jun 17. doi: 10.1074/jbc.M114.558890

PMCID:: PMC4118115

Abstract Article PDF–5.9M

Select item 384305117.

Cytosolic Sulfotransferase 1A3 Is Induced by Dopamine and Protects Neuronal Cells from Dopamine Toxicity: ROLE OF D1 RECEPTOR-N-METHYL-d-ASPARTATE RECEPTOR COUPLING

Neelima P. Sidharthan, Rodney F. Minchin, Neville J. Butcher

J Biol Chem. 2013 Nov 29; 288(48): 34364–34374. Published online 2013 Oct 17. doi: 10.1074/jbc.M113.493239

PMCID:: PMC3843051

Abstract Article PDF–1.7M

Select item 374342518.

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

Yugang Wang, Goleeta N. Alam, Yu Ning, Fernanda Visioli, Zhihong Dong, Jacques E. Nör, Peter J. Polverini

Cancer Res. Author manuscript; available in PMC 2013 Oct 15.

Published in final edited form as: Cancer Res. 2012 Oct 15; 72(20): 5396–5406. Published online 2012 Aug 20. doi: 10.1158/0008-5472.CAN-12-0474

PMCID:: PMC3743425

Abstract Article PDF–6.1M

Select item 371161819.

ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin

Xiaotian Sun, Jin Liu, John F. Crary, Cristina Malagelada, David Sulzer, Lloyd A. Greene, Oren A. Levy

J Neurosci. 2013 Feb 6; 33(6): 2398–2407. doi: 10.1523/JNEUROSCI.2292-12.2013

PMCID:: PMC3711618

Abstract Article PDF–1.8M

Select item 368462820.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Alfred Csibi, Sarah-Maria Fendt, Chenggang Li, George Poulogiannis, Andrew Y. Choo, Douglas J. Chapski, Seung Min Jeong, Jamie Dempsey, Andrey Parkhitko, Tasha Morrison, Elizabeth Henske, Marcia Haigis, Lewis C. Cantley, Gregory Stephanopoulos, Jane Yu, John Blenis

Cell. Author manuscript; available in PMC 2014 May 9.

Published in final edited form as: Cell. 2013 May 9; 153(4): 840–854. doi: 10.1016/j.cell.2013.04.023