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Items: 1 to 20 of 29

1.
MKK4 Knockdown Plays a Protective Role in Hemorrhagic Shock-Induced Liver Injury through the JNK Pathway
Hao Yao, Yu Gao, Jiahui Han, Yan Wang, Jimin Cai, Yongjun Rui, Xin Ge
Oxid Med Cell Longev. 2022; 2022: 5074153. Published online 2022 Sep 17. doi: 10.1155/2022/5074153
PMCID:
PMC9509254
AbstractArticlePDF–1.5M
2.
The Similar Effects of miR-512-3p and miR-519a-2-5p on the Promotion of Hepatocellular Carcinoma: Different Tunes Sung With Equal Skill
Tao Rui, Xueyou Zhang, Shi Feng, Haitao Huang, Shaowei Zhan, Haiyang Xie, Lin Zhou, Qi Ling, Shusen Zheng
Front Oncol. 2020; 10: 1244. Published online 2020 Aug 7. doi: 10.3389/fonc.2020.01244
PMCID:
PMC7427533
AbstractArticlePDF–4.5M
3.
MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies
Jun Lu, Nina Zhou, Ping Yang, Lanqiuzi Deng, Ganzhe Liu
Med Sci Monit. 2019; 25: 8499–8508. Published online 2019 Nov 11. doi: 10.12659/MSM.916458
PMCID:
PMC6865231
AbstractArticlePDF–1.9M
4.
MicroRNA‐802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4
Xiaozhen Wu, Zuode Gong, Lanying Sun, Long Ma, Qibao Wang
Cell Prolif. 2017 Jun; 50(3): e12336. Published online 2017 Mar 20. doi: 10.1111/cpr.12336
PMCID:
PMC6529076
AbstractArticlePDF–901K
5.
MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4
Guoli Hu, Xiaoying Zhao, Chuandong Wang, Yiyun Geng, Jingyu Zhao, Jiajia Xu, Bin Zuo, Chen Zhao, Chenglong Wang, Xiaoling Zhang
Cell Death Dis. 2017 Oct; 8(10): e3140. Published online 2017 Oct 26. doi: 10.1038/cddis.2017.522
PMCID:
PMC5682684
AbstractArticlePDF–6.1M
6.
Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients
Michelle A. T. Hildebrandt, Jack A. Roth, Ara A. Vaporciyan, Xia Pu, Yuanqing Ye, Arlene M. Correa, Jae Y. Kim, Stephen G. Swisher, Xifeng Wu
Sci Rep. 2015; 5: 12068. Published online 2015 Jul 13. doi: 10.1038/srep12068
PMCID:
PMC4499815
AbstractArticlePDF–420K
7.
Curcumin Induced Human Gastric Cancer BGC-823 Cells Apoptosis by ROS-Mediated ASK1-MKK4-JNK Stress Signaling Pathway
Tao Liang, Xiaojian Zhang, Wenhua Xue, Songfeng Zhao, Xiang Zhang, Jianying Pei
Int J Mol Sci. 2014 Sep; 15(9): 15754–15765. Published online 2014 Sep 5. doi: 10.3390/ijms150915754
PMCID:
PMC4200840
AbstractArticlePDF–2.2M
8.
ZPK/DLK and MKK4 Form the Critical Gateway to Axotomy-Induced Motoneuron Death in Neonates
Takayuki Itoh, Makoto Horiuchi, Raymond H. Ikeda, Jr, Jie Xu, Peter Bannerman, David Pleasure, Josef M. Penninger, Cathy Tournier, Aki Itoh
J Neurosci. 2014 Aug 6; 34(32): 10729–10742. doi: 10.1523/JNEUROSCI.0539-14.2014
PMCID:
PMC4200111
AbstractArticlePDF–11M
9.
Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age
Laura Davies, Jiawei Jin, Weijin Shen, Hoyee Tsui, Ying Shi, Yanwen Wang, Yanmin Zhang, Guoliang Hao, Jingjing Wu, Si Chen, James A. Fraser, Nianguo Dong, Vincent Christoffels, Ursula Ravens, Christopher L.‐H. Huang, Henggui Zhang, Elizabeth J. Cartwright, Xin Wang, Ming Lei
J Am Heart Assoc. 2014 Apr; 3(2): e000340. Published online 2014 Apr 25. doi: 10.1161/JAHA.113.000340
PMCID:
PMC4187508
AbstractArticlePDF–1.5M
10.
miR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4–JNK pathway
Lan Zhang, Mi Zhou, Yingjie Wang, Weibin Huang, Gangjian Qin, Neal L. Weintraub, Yaoliang Tang
Apoptosis. Author manuscript; available in PMC 2014 Aug 26.
Published in final edited form as: Apoptosis. 2014 Jun; 19(6): 975–983. doi: 10.1007/s10495-014-0987-y
PMCID:
PMC4143895
AbstractArticlePDF–1.7M
11.
Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death
Alice YW Chang
J Biomed Sci. 2012; 19(1): 96. Published online 2012 Nov 17. doi: 10.1186/1423-0127-19-96
PMCID:
PMC3533910
AbstractArticlePDF–1.7M
12.
MKK4 Suppresses Metastatic Colonization by Multiple Highly Metastatic Prostate Cancer Cell Lines Through a Transient Impairment in Cell Cycle Progression
Russell Z Szmulewitz, Robert Clark, Tamara Lotan, Kristen Otto, Jennifer Taylor Veneris, Kay Macleod, Carrie Rinker-Schaeffer
Int J Cancer. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: Int J Cancer. 2012 Feb 1; 130(3): 509–520. Published online 2011 Apr 25. doi: 10.1002/ijc.26005
PMCID:
PMC3465713
AbstractArticlePDF–2.1M
13.
Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor γ2 Expression
Young-Ho Ahn, Yanan Yang, Don L. Gibbons, Chad J. Creighton, Fei Yang, Ignacio I. Wistuba, Wei Lin, Nishan Thilaganathan, Cristina A. Alvarez, Jonathon Roybal, Elizabeth J. Goldsmith, Cathy Tournier, Jonathan M. Kurie
Mol Cell Biol. 2011 Nov; 31(21): 4270–4285. doi: 10.1128/MCB.05562-11
PMCID:
PMC3209326
AbstractArticlePDF–6.4M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
Mitogen-activated Protein Kinase Kinase 4 Deficiency in Cardiomyocytes Causes Connexin 43 Reduction and Couples Hypertrophic Signals to Ventricular Arrhythmogenesis
Min Zi, Tomomi E. Kimura, Wei Liu, Jiawei Jin, Jonathan Higham, Sanjay Kharche, Guoliang Hao, Ying Shi, Weijian Shen, Sukhpal Prehar, Aleksandr Mironov, Ludwig Neyses, Marti F. A. Bierhuizen, Mark R. Boyett, Henggui Zhang, Ming Lei, Elizabeth J. Cartwright, Xin Wang
J Biol Chem. 2011 May 20; 286(20): 17821–17830. Published online 2011 Mar 28. doi: 10.1074/jbc.M111.228791
PMCID:
PMC3093857
ArticlePDF–1.6M
16.
7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses Ultraviolet B-induced Skin Cancer by Targeting Cot and MKK4
Dong Eun Lee, Ki Won Lee, Sanguine Byun, Sung Keun Jung, Nury Song, Sung Hwan Lim, Yong-Seok Heo, Jong Eun Kim, Nam Joo Kang, Bo Yeon Kim, G. Tim Bowden, Ann M. Bode, Hyong Joo Lee, Zigang Dong
J Biol Chem. 2011 Apr 22; 286(16): 14246–14256. Published online 2011 Mar 4. doi: 10.1074/jbc.M110.147348
PMCID:
PMC3077626
AbstractArticlePDF–3.3M
17.
Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia
Stephen J. Harding, Gareth J. Browne, Bryan W. Miller, Sally A. Prigent, Martin Dickens
Biochim Biophys Acta. 2010 Sep; 1802(9): 733–740. doi: 10.1016/j.bbadis.2010.06.005
PMCID:
PMC2954285
AbstractArticle
18.
The mitogen-activated protein kinase kinase 4 (MKK4) has a pro-oncogenic role in skin cancer
Katherine G. Finegan, Cathy Tournier
Cancer Res. Author manuscript; available in PMC 2011 Jan 15.
Published in final edited form as: Cancer Res. 2010 Jul 15; 70(14): 5797–5806. Published online 2010 Jul 7. doi: 10.1158/0008-5472.CAN-09-3669
PMCID:
PMC2906708
AbstractArticlePDF–2.1M
19.
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones, Xiaosong Zhang, D. Williams Parsons, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, Hirohiko Kamiyama, Antonio Jimeno, Seung-Mo Hong, Baojin Fu, Ming-Tseh Lin, Eric S. Calhoun, Mihoko Kamiyama, Kimberly Walter, Tatiana Nikolskaya, Yuri Nikolsky, James Hartigan, Douglas R. Smith, Manuel Hidalgo, Steven D. Leach, Alison P. Klein, Elizabeth M. Jaffee, Michael Goggins, Anirban Maitra, Christine Iacobuzio-Donahue, James R. Eshleman, Scott E. Kern, Ralph H. Hruban, Rachel Karchin, Nickolas Papadopoulos, Giovanni Parmigiani, Bert Vogelstein, Victor E. Velculescu, Kenneth W. Kinzler
Science. Author manuscript; available in PMC 2010 Apr 4.
Published in final edited form as: Science. 2008 Sep 26; 321(5897): 1801–1806. Published online 2008 Sep 4. doi: 10.1126/science.1164368
PMCID:
PMC2848990
AbstractArticlePDF–971K
20.
Association of Genetic Variation in Mitotic Kinases with Breast Cancer Risk
Xianshu Wang, Zachary S. Fredericksen, Robert A. Vierkant, V. Shane Pankratz, James R. Cerhan, Christina Justenhoven, Hiltrud Brauch, GENICA Consortium, Janet E. Olson, Fergus J. Couch
Breast Cancer Res Treat. Author manuscript; available in PMC 2011 Jan 1.
Published in final edited form as: Breast Cancer Res Treat. 2010 Jan; 119(2): 453–462. Published online 2009 Apr 30. doi: 10.1007/s10549-009-0404-3
PMCID:
PMC2796295
AbstractArticlePDF–174K

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