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Select item 101795601.

PIMT Controls Insulin Synthesis and Secretion through PDX1

Rahul Sharma, Sujay K. Maity, Partha Chakrabarti, Madhumohan R. Katika, Satyamoorthy Kapettu, Kishore V. L. Parsa, Parimal Misra

Int J Mol Sci. 2023 May; 24(9): 8084. Published online 2023 Apr 29. doi: 10.3390/ijms24098084

PMCID:: PMC10179560

Abstract Article PDF–4.9M

Select item 74899132.

Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress

Xinlei Yao, Kun Li, Chen Liang, Zilong Zhou, Jiao Wang, Shuyue Wang, Lei Liu, Chun-Lei Yu, Zhen-Bo Song, Yong-Li Bao, Li-Hua Zheng, Ying Sun, Guannan Wang, Yanxin Huang, Jingwen Yi, Luguo Sun, Yuxin Li

J Biol Chem. 2020 Sep 11; 295(37): 12975–12992. Published online 2020 Jul 20. doi: 10.1074/jbc.RA120.012849

PMCID:: PMC7489913

Abstract Article PDF–7.2M

Select item 67406723.

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Markus Schubert, Derek P. Brazil, Deborah J. Burks, Jake A. Kushner, Jing Ye, Carrie L. Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M. Warot, Carlos Rio, Gabriel Corfas, Morris F. White

J Neurosci. 2003 Aug 6; 23(18): 7084–7092. doi: 10.1523/JNEUROSCI.23-18-07084.2003

PMCID:: PMC6740672

Abstract Article PDF–461K

Select item 66431364.

Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity

Chen Liang, Fang Hao, Xinlei Yao, Ye Qiu, Lei Liu, Shuyue Wang, Chunlei Yu, Zhenbo Song, Yongli Bao, Jingwen Yi, Yanxin Huang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Xiaoguang Yang, Shaonian Yang, Luguo Sun, Yuxin Li

Int J Biol Sci. 2019; 15(7): 1472–1487. Published online 2019 Jun 2. doi: 10.7150/ijbs.33817

PMCID:: PMC6643136

Abstract Article PDF–2.7M

Select item 63077955.

Liraglutide protects against glucolipotoxicity‐induced RIN‐m5F β‐cell apoptosis through restoration of PDX1 expression

Edy Kornelius, Hsin‐Hua Li, Chiung‐Huei Peng, Yi‐Sun Yang, Wei‐Jen Chen, Yan‐Zin Chang, Yi‐Chiao Bai, Stanley Liu, Chien‐Ning Huang, Chih‐Li Lin

J Cell Mol Med. 2019 Jan; 23(1): 619–629. Published online 2018 Oct 24. doi: 10.1111/jcmm.13967

PMCID:: PMC6307795

Abstract Article PDF–1.9M

Select item 62454186.

Overexpression of the Pdx-1 Homeodomain Transcription Factor Impairs Glucose Metabolism in Cultured Rat Hepatocytes

Rudolf Tito Pillich, Gianfranco Scarsella, Gianfranco Risuleo

Molecules. 2008 Oct; 13(10): 2659–2673. Published online 2008 Oct 28. doi: 10.3390/molecules13102659

PMCID:: PMC6245418

Abstract Article PDF–412K

Select item 54173737.

The Activation of the Rat Insulin Gene II by BETA2 and PDX-1 in Rat Insulinoma Cells Is Repressed by Pax6

Gabriele Wolf, Behnam Hessabi, Anke Karkour, Ulrike Henrion, Meike Dahlhaus, Annett Ostmann, Bernd Giese, Martin Fraunholz, Piotr Grabarczyk, Robert Jack, Reinhard Walther

Mol Endocrinol. December 1, 2010; 24(12): 2331–2342. doi: 10.1210/me.2009-0220

PMCID:: PMC5417373

Abstract Article

Select item 51088808.

A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation

Heather L. Hayes, Lu Zhang, Thomas C. Becker, Jonathan M. Haldeman, Samuel B. Stephens, Michelle Arlotto, Larry G. Moss, Christopher B. Newgard, Hans E. Hohmeier

Mol Cell Biol. 2016 Dec 1; 36(23): 2918–2930. Prepublished online 2016 Sep 12. Published online 2016 Nov 14. doi: 10.1128/MCB.00103-16

PMCID:: PMC5108880

Abstract Article PDF–2.0M

Select item 41713059.

In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells

Tao Liu, Chun-You Wang, Feng Yu, Shan-Miao Gou, He-Shui Wu, Jiong-Xin Xiong, Feng Zhou

World J Gastroenterol. 2007 Oct 21; 13(39): 5232–5237. Published online 2007 Oct 21. doi: 10.3748/wjg.v13.i39.5232

PMCID:: PMC4171305

Abstract Article PDF–724K

Select item 401286210.

Pdx1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

Benoit R. Gauthier, Andreas Wiederkehr, Maturin Baquié, Chunhua Dai, Alvin C. Powers, Julie Kerr-Conte, François Pattou, Raymond J. MacDonald, Jorge Ferrer, Claes B. Wollheim

Cell Metab. Author manuscript; available in PMC 2014 May 7.

Published in final edited form as: Cell Metab. 2009 Aug; 10(2): 110–118. doi: 10.1016/j.cmet.2009.07.002

PMCID:: PMC4012862

Abstract Article PDF–3.7M

Select item 400781411.

AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARα, but not PPARγ, in rat insulinoma cell line INS-1

Hua Guo, Shui Sun, Xu Zhang, Xiu-juan Zhang, Ling Gao, Jia-jun Zhao

Acta Pharmacol Sin. 2010 Aug; 31(8): 963–969. Published online 2010 Jul 19. doi: 10.1038/aps.2010.78

PMCID:: PMC4007814

Abstract Article PDF–5.5M

Select item 393242812.

Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium

Karen L Seeberger, Sarah J Anderson, Cara E Ellis, Telford Y Yeung, Gregory S Korbutt

World J Diabetes. 2014 Feb 15; 5(1): 59–68. Published online 2014 Feb 15. doi: 10.4239/wjd.v5.i1.59

PMCID:: PMC3932428

Abstract Article PDF–1.3M

Select item 382288213.

AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma β-cells

Xiujuan Zhang, Nannan Sun, Laicheng Wang, Hua Guo, Qingbo Guan, Bin Cui, Limin Tian, Ling Gao, Jiajun Zhao

J Cell Mol Med. 2009 Apr; 13(4): 758–770. Published online 2009 Apr 22. doi: 10.1111/j.1582-4934.2009.00656.x

PMCID:: PMC3822882

Abstract Article PDF–6.4M

Select item 375017714.

Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells

Meriem Semache, Bader Zarrouki, Ghislaine Fontés, Sarah Fogarty, Chintan Kikani, Mohammad B. Chawki, Jared Rutter, Vincent Poitout

J Biol Chem. 2013 Aug 23; 288(34): 24825–24833. Published online 2013 Jul 12. doi: 10.1074/jbc.M113.495945

PMCID:: PMC3750177

Abstract Article PDF–1.5M

Select item 367440815.

B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells

Seung-Lark Hwang, Okyun Kwon, Sun-Gyun Kim, In-Kyu Lee, Yong Deuk Kim

Exp Mol Med. 2013 May; 45(5): e25. Published online 2013 May 24. doi: 10.1038/emm.2013.47

PMCID:: PMC3674408

Abstract Article PDF–678K

Select item 357042316.

PPARγ Activation Attenuates Glycated-Serum Induced Pancreatic Beta-Cell Dysfunction through Enhancing Pdx1 and Mafa Protein Stability

Yunxia Zhu, Ai Ma, Hongxiu Zhang, Chaojun Li

PLoS One. 2013; 8(2): e56386. Published online 2013 Feb 12. doi: 10.1371/journal.pone.0056386

PMCID:: PMC3570423

Abstract Article PDF–1.2M

Select item 342221517.

High Glucose Is Necessary for Complete Maturation of Pdx1-VP16 –Expressing Hepatic Cells into Functional Insulin-Producing Cells

Li-Zhen Cao, Dong-Qi Tang, Marko E. Horb, Shi-Wu Li, Li-Jun Yang

Diabetes. Author manuscript; available in PMC 2012 Aug 17.

Published in final edited form as: Diabetes. 2004 Dec; 53(12): 3168–3178. doi: 10.2337/diabetes.53.12.3168

PMCID:: PMC3422215

Abstract Article PDF–2.4M

Select item 325729818.

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production

Gregory M. Ku, Zachary Pappalardo, Chun Chieh Luo, Michael S. German, Michael T. McManus

PLoS Genet. 2012 Jan; 8(1): e1002449. Published online 2012 Jan 12. doi: 10.1371/journal.pgen.1002449

PMCID:: PMC3257298

Abstract Article PDF–1.2M

Select item 319654019.

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

Michal Mauda-Havakuk, Naomi Litichever, Ellad Chernichovski, Odelia Nakar, Eyal Winkler, Ram Mazkereth, Arie Orenstein, Eran Bar-Meir, Philippe Ravassard, Irit Meivar-Levy, Sarah Ferber

PLoS One. 2011; 6(10): e26298. Published online 2011 Oct 18. doi: 10.1371/journal.pone.0026298