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Select item 99961931.

Ninety-six–hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions

Maryam Mehri, Reza Gheitasi, Roghayeh Pourbagher, Mohammad Ranaee, Kosar Nayeri, Seyed Mostafa Rahimi, Hamid Reza Khorasani, Hadi Hossein-Nattaj, Davood Sabour, Haleh Akhavan-Niaki, Sadegh Fattahi, Behnam Kalali, Amrollah Mostafazadeh

Front Immunol. 2022; 13: 1025933. Published online 2023 Feb 23. doi: 10.3389/fimmu.2022.1025933

PMCID:: PMC9996193

Abstract Article PDF–3.9M

Select item 87345932.

COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl₄-Induced Liver Fibrosis and Portal Hypertension

Zhifeng Zhao, Chihao Zhang, Jiayun Lin, Lei Zheng, Hongjie Li, Xiaoliang Qi, Haizhong Huo, Xiaolou Lou, Bruce D. Hammock, Sung Hee Hwang, Yongyang Bao, Meng Luo

Front Med (Lausanne) 2021; 8: 761517. Published online 2021 Dec 23. doi: 10.3389/fmed.2021.761517

PMCID:: PMC8734593

Abstract Article PDF–4.6M

Select item 82012593.

Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate Vascular Pathology and Metabolic Syndrome in SHR Rats Held on High Fat Diet

Michael Ezrokhi, Yahong Zhang, Shuqin Luo, Anthony H. Cincotta

Int J Mol Sci. 2021 Jun; 22(11): 6142. Published online 2021 Jun 7. doi: 10.3390/ijms22116142

PMCID:: PMC8201259

Abstract Article PDF–12M

Select item 81005954.

Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH₄/eNOS to Improve Intestinal Ischemia

Tao Yan, Shun Guo, Tian Zhang, Zhimin Zhang, An Liu, Song Zhang, Yuan Xu, Yuhong Qi, Weihe Zhao, Qinhui Wang, Lei Shi, Linna Liu

Front Pharmacol. 2021; 12: 629125. Published online 2021 Apr 22. doi: 10.3389/fphar.2021.629125

PMCID:: PMC8100595

Abstract Article PDF–3.1M

Select item 80492465.

L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH₄

Zhengjun Wang, Chen Cheng, Xiaoyu Yang, Chen Zhang

PLoS One. 2021; 16(4): e0250126. Published online 2021 Apr 15. doi: 10.1371/journal.pone.0250126

PMCID:: PMC8049246

Abstract Article PDF–967K

Select item 74195406.

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status

Maria del Carmen Asensio Lopez, Antonio Lax, Alvaro Hernandez Vicente, Elena Saura Guillen, Antonio Hernandez-Martinez, Maria Josefa Fernandez del Palacio, Andoni Bayes Genis, Domingo A. Pascual Figal

Sci Rep. 2020; 10: 13553. Published online 2020 Aug 11. doi: 10.1038/s41598-020-70454-8

Correction in:: Sci Rep. 2020; 10: 17266.

PMCID:: PMC7419540

Abstract Article PDF–9.2M

Select item 67821387.

Blockade of Tetrahydrobiopterin Synthesis Protects Neurons after Transient Forebrain Ischemia in Rat: A Novel Role for the Cofactor

Sunghee Cho, Bruce T. Volpe, Youngmee Bae, Onyou Hwang, Hyun J. Choi, Judit Gal, Larry C. H. Park, Chung K. Chu, Jinfa Du, Tong H. Joh

J Neurosci. 1999 Feb 1; 19(3): 878–889. doi: 10.1523/JNEUROSCI.19-03-00878.1999

PMCID:: PMC6782138

Abstract Article PDF–1.0M

Select item 67587368.

Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic l-Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat Model of Parkinson's Disease.

Mimoun Azzouz, Enca Martin-Rendon, Robert D. Barber, Kyriacos A. Mitrophanous, Emma E. Carter, Jonathan B. Rohll, Susan M. Kingsman, Alan J. Kingsman, Nicholas D. Mazarakis

J Neurosci. 2002 Dec 1; 22(23): 10302–10312. doi: 10.1523/JNEUROSCI.22-23-10302.2002

PMCID:: PMC6758736

Abstract Article PDF–1.2M

Select item 65273639.

Exercise training augments neuronal nitric oxide synthase dimerization in the paraventricular nucleus of rats with chronic heart failure

Neeru M. Sharma, Xuefei Liu, Tamra L. Llewellyn, Kenichi Katsurada, Kaushik P. Patel

Nitric Oxide. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Nitric Oxide. 2019 Jun 1; 87: 73–82. Published online 2019 Mar 13. doi: 10.1016/j.niox.2019.03.005

PMCID:: PMC6527363

Abstract Article PDF–935K

Select item 557064410.

Caffeine Ameliorates Hyperoxia-Induced Lung Injury by Protecting GCH1 Function in Neonatal Rat Pups

Xigang Jing, Yi-Wen Huang, Jason Jarzembowski, Yang Shi, Girija G. Konduri, Ru-Jeng Teng

Pediatr Res. Author manuscript; available in PMC 2017 Nov 24.

Published in final edited form as: Pediatr Res. 2017 Sep; 82(3): 483–489. Published online 2017 May 24. doi: 10.1038/pr.2017.89

PMCID:: PMC5570644

Abstract Article PDF–638K

Select item 490474111.

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy

Hsiang-En Wu, Shelley L. Baumgardt, Juan Fang, Mark Paterson, Yanan Liu, Jianhai Du, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, David C. Warltier, Judy R. Kersten, Zhi-Dong Ge

Sci Rep. 2016; 6: 27925. Published online 2016 Jun 13. doi: 10.1038/srep27925

PMCID:: PMC4904741

Abstract Article PDF–2.4M

Select item 454344112.

Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats

Ines Baotic, Dorothee Weihrauch, Jesse Procknow, Jeanette Vasquez-Vivar, Zhi-Dong Ge, Shaan Sudhakaran, David C. Warltier, Judy R. Kersten

Anesthesiology. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Anesthesiology. 2015 Sep; 123(3): 582–589. doi: 10.1097/ALN.0000000000000778

PMCID:: PMC4543441

Abstract Article PDF–840K

Select item 442404013.

Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease

Erik Cederfjäll, Lauren Broom, Deniz Kirik

Mol Ther. 2015 May; 23(5): 896–906. Prepublished online 2015 Jan 16. Published online 2015 Feb 17. doi: 10.1038/mt.2015.8

PMCID:: PMC4424040

Abstract Article PDF–2.2M

Select item 434799314.

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

Gillian Douglas, Ashley B. Hale, Mark J Crabtree, Brent J. Ryan, Alex Hansler, Katrin Watschinger, Steven S Gross, Craig A. Lygate, Nicholas J. Alp, Keith M. Channon

Dev Biol. 2015 Mar 1; 399(1): 129–138. doi: 10.1016/j.ydbio.2014.12.025

PMCID:: PMC4347993

Abstract Article

Select item 428109215.

A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia

Inna Belfer, Victoria Youngblood, Deepika S. Darbari, Zhengyuan Wang, Lena Diaw, Lita Freeman, Krupa Desai, Michael Dizon, Darlene Allen, Colin Cunnington, Keith M. Channon, Jacqueline Milton, Stephen W. Hartley, Vikki Nolan, Gregory J. Kato, Martin H. Steinberg, David Goldman, James G. Taylor, VI

Am J Hematol. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Am J Hematol. 2014 Feb; 89(2): 187–193. doi: 10.1002/ajh.23613

PMCID:: PMC4281092

Abstract Article PDF–998K

Select item 421967116.

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Pawel P. Wolkow, Wladyslaw Kosiniak-Kamysz, Grzegorz Osmenda, Grzegorz Wilk, Beata Bujak-Gizycka, Adam Ignacak, Mihir Kanitkar, Malgorzata Walus-Miarka, David G. Harrison, Ryszard Korbut, Maciej T. Malecki, Tomasz J. Guzik

PLoS One. 2014; 9(11): e108587. Published online 2014 Nov 4. doi: 10.1371/journal.pone.0108587