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Select item 71138381.

Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension

Xiao-Jian Wang, Xi-Qi Xu, Kai Sun, Ke-Qiang Liu, Su-Qi Li, Xin Jiang, Qin-Hua Zhao, Lan Wang, Fu-Hua Peng, Jue Ye, Yan Wu, Rui Jiang, Jin Zhang, Wei Huang, Wen-Bin Wei, Yi Yan, Jing-Hui Li, Qian-Qian Liu, Sheng Li, Yong Wang, Shu-Yang Zhang, Xue Zhang, Zhi-Cheng Jing

JAMA Cardiol. 2020 Jun; 5(6): 1–8. Published online 2020 Apr 1. doi: 10.1001/jamacardio.2020.0479

PMCID:: PMC7113838

Abstract Article

Select item 64356272.

Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury

Yingxue Cao, Yi Guan, Yun-Yu Xu, Chuan-Ming Hao

Pflugers Arch. 2019; 471(4): 543–555. Published online 2018 Nov 9. doi: 10.1007/s00424-018-2229-6

PMCID:: PMC6435627

Abstract Article PDF–2.9M

Select item 62500013.

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma

Anelise Russo, Patrícia M. Biselli-Chicote, Rosa S. Kawasaki-Oyama, Márcia M. U. Castanhole-Nunes, José V. Maniglia, Dalísio de Santi Neto, Érika C. Pavarino, Eny M. Goloni-Bertollo

J Oncol. 2018; 2018: 6301980. Published online 2018 Nov 8. doi: 10.1155/2018/6301980

PMCID:: PMC6250001

Abstract Article PDF–1.8M

Select item 55075144.

Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients

Xingyang Yi, Jing Lin, Hua Luo, Chun Wang, Yingying Liu

PLoS One. 2017; 12(7): e0180704. Published online 2017 Jul 12. doi: 10.1371/journal.pone.0180704

PMCID:: PMC5507514

Abstract Article PDF–922K

Select item 53365775.

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats

Gemma Sangüesa, Sonali Shaligram, Farjana Akther, Núria Roglans, Juan C. Laguna, Roshanak Rahimian, Marta Alegret

Am J Physiol Heart Circ Physiol. 2017 Feb 1; 312(2): H289–H304. Published online 2016 Dec 6. doi: 10.1152/ajpheart.00339.2016

PMCID:: PMC5336577

Abstract Article

Select item 47749456.

Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1

Hélène Choquet, Eliana Trapani, Luca Goitre, Lorenza Trabalzini, Amy Akers, Marco Fontanella, Blaine L. Hart, Leslie A. Morrison, Ludmila Pawlikowska, Helen Kim, Saverio Francesco Retta

Free Radic Biol Med. 2016 Mar; 92: 100–109. doi: 10.1016/j.freeradbiomed.2016.01.008

PMCID:: PMC4774945

Abstract Article

Select item 46617037.

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1

Yuka Sasaki, Shuhei Kamiyama, Azusa Kamiyama, Konomi Matsumoto, Moe Akatsu, Yoshihito Nakatani, Hiroshi Kuwata, Yukio Ishikawa, Toshiharu Ishii, Chieko Yokoyama, Shuntaro Hara

Sci Rep. 2015; 5: 17376. Published online 2015 Nov 27. doi: 10.1038/srep17376

PMCID:: PMC4661703

Abstract Article PDF–1.4M

Select item 40981078.

Functional Prostacyclin Synthase Promoter Polymorphisms. Impact in Pulmonary Arterial Hypertension

Robert S. Stearman, Amber R. Cornelius, Xiao Lu, David S. Conklin, Mark J. Del Rosario, Anita M. Lowe, Mihret T. Elos, Lynsey M. Fettig, Randall E. Wong, Naoko Hara, Joy D. Cogan, John A. Phillips, III, Matthew R. Taylor, Brian B. Graham, Rubin M. Tuder, James E. Loyd, Mark W. Geraci

Am J Respir Crit Care Med. 2014 May 1; 189(9): 1110–1120. Published online 2014 May 1. doi: 10.1164/rccm.201309-1697OC

PMCID:: PMC4098107

Abstract Article PDF–869K

Select item 36497529.

Enhanced Prostacyclin Synthesis by Adenoviral Gene Transfer Reduced Glial Activation and Ameliorated Dopaminergic Dysfunction in Hemiparkinsonian Rats

May-Jywan Tsai, Ching-Feng Weng, Nien-Chu Yu, Dann-Ying Liou, Fu-San Kuo, Ming-Chao Huang, Wen-Cheng Huang, Kabik Tam, Song-Kun Shyue, Henrich Cheng

Oxid Med Cell Longev. 2013; 2013: 649809. Published online 2013 Apr 3. doi: 10.1155/2013/649809

PMCID:: PMC3649752

Abstract Article PDF–5.7M

Select item 340083110.

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

Batoule H. Majed, Raouf A. Khalil

Pharmacol Rev. 2012 Jul; 64(3): 540–582. doi: 10.1124/pr.111.004770

PMCID:: PMC3400831

Abstract Article PDF–1012K

Select item 328416411.

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

Mercedes Camacho, Cristina Rodríguez, Anna Guadall, Sonia Alcolea, Mar Orriols, José-Román Escudero, José Martínez-González, Luis Vila

J Lipid Res. 2011 Apr; 52(4): 720–731. doi: 10.1194/jlr.M011007

PMCID:: PMC3284164

Abstract Article PDF–1.4M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 304677313.

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

Cheng-Huai Ruan, Shui-Ping So, Ke-He Ruan

Life Sci. Author manuscript; available in PMC 2012 Jan 3.

Published in final edited form as: Life Sci. 2011 Jan 3; 88(1-2): 24–30. Published online 2010 Oct 28. doi: 10.1016/j.lfs.2010.10.017

PMCID:: PMC3046773

Abstract Article PDF–2.2M

Select item 285698914.

Protection against Cytokine Toxicity through Endoplasmic Reticulum and Mitochondrial Stress Prevention by Prostacyclin Synthase Overexpression in Insulin-producing Cells

Ewa Gurgul-Convey, Sigurd Lenzen

J Biol Chem. 2010 Apr 9; 285(15): 11121–11128. Published online 2010 Feb 16. doi: 10.1074/jbc.M109.054775

PMCID:: PMC2856989

Abstract Article PDF–767K

Select item 275318315.

Variation in Eicosanoid Genes, Non-fatal Myocardial Infarction and Ischemic Stroke

Rozenn N. Lemaitre, Kenneth Rice, Kristin Marciante, Joshua C. Bis, Thomas S. Lumley, Kerri L. Wiggins, Nicholas L. Smith, Susan R. Heckbert, Bruce M. Psaty

Atherosclerosis. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Atherosclerosis. 2009 Jun; 204(2): e58–e63. Published online 2008 Nov 1. doi: 10.1016/j.atherosclerosis.2008.10.011

PMCID:: PMC2753183

Abstract Article PDF–67K

Select item 273495216.

Determination of Genetic Predisposition to Patent Ductus Arteriosus in Preterm Infants

John M Dagle, Nathan T Lepp, Margaret E Cooper, Kendra L Schaa, Keegan JP Kelsey, Kristin L Orr, Diana Caprau, Cara R Zimmerman, Katherine M Steffen, Karen J Johnson, Mary L Marazita, Jeffrey C Murray

Pediatrics. Author manuscript; available in PMC 2009 Aug 30.

Published in final edited form as: Pediatrics. 2009 Apr; 123(4): 1116–1123. doi: 10.1542/peds.2008-0313