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Select item 111359941.

Regulation of insulin receptor function

J. F. Youngren

Cell Mol Life Sci. 2007 Apr; 64(7-8): 873. Published online 2007 Mar 8. doi: 10.1007/s00018-007-6359-9

PMCID:: PMC11135994

Abstract Article PDF–600K

Select item 89691232.

p66Shc Signaling does not Contribute to Tubular Damage Induced by Renal Ischemia-Reperfusion Injury in Rat

Bradley Miller, Kevin Regner, Andrey Sorokin

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 May 7.

Published in final edited form as: Biochem Biophys Res Commun. 2022 May 7; 603: 69–74. Published online 2022 Mar 3. doi: 10.1016/j.bbrc.2022.03.020

PMCID:: PMC8969123

Abstract Article PDF–1.1M

Select item 88342313.

Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension

William E. Hughes, Joe Hockenberry, Bradley Miller, Andrey Sorokin, Andreas M. Beyer

Am J Physiol Heart Circ Physiol. 2021 Dec 1; 321(6): H1096–H1102. Published online 2021 Oct 29. doi: 10.1152/ajpheart.00542.2021

PMCID:: PMC8834231

Abstract Article

Select item 82652154.

p66Shc-Mediated Hydrogen Peroxide Production Impairs Nephrogenesis Causing Reduction of Number of Glomeruli

Bradley Miller, Oleg Palygin, Ashraf El-Meanawy, David L. Mattson, Aron M. Geurts, Alexander Staruschenko, Andrey Sorokin

Life Sci. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Life Sci. 2021 Aug 15; 279: 119661. Published online 2021 Jun 2. doi: 10.1016/j.lfs.2021.119661

PMCID:: PMC8265215

Abstract Article PDF–718K

Select item 81559735.

Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy

Bradley Miller, Tatiana Y. Kostrominova, Aron M. Geurts, Andrey Sorokin

Int J Mol Sci. 2021 May; 22(10): 5237. Published online 2021 May 15. doi: 10.3390/ijms22105237

PMCID:: PMC8155973

Abstract Article PDF–3.3M

Select item 78893456.

RXRα Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc

Pei Yu, Kai Yang, Min Jiang

Oxid Med Cell Longev. 2021; 2021: 8253742. Published online 2021 Feb 10. doi: 10.1155/2021/8253742

PMCID:: PMC7889345

Abstract Article PDF–1.8M

Select item 71525407.

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis

Hyo Jung Shin, Hyewon Park, Nara Shin, Juhee Shin, Do Hyeong Gwon, Hyeok Hee Kwon, Yuhua Yin, Jeong-Ah Hwang, Jinpyo Hong, Jun Young Heo, Cuk-Seong Kim, Yongbum Joo, Youngmo Kim, Jinhyun Kim, Jaewon Beom, Dong Woon Kim

Int J Nanomedicine. 2020; 15: 2379–2390. Published online 2020 Apr 8. doi: 10.2147/IJN.S234198

PMCID:: PMC7152540

Abstract Article PDF–5.8M

Select item 67513358.

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

Cong Hao, Xuewen Wu, Ruoyu Zhou, Hao Zhang, Yulai Zhou, Xinxing Wang, Yong Feng, Lingyun Mei, Chufeng He, Xinzhang Cai, Lisha Wu

Drug Des Devel Ther. 2019; 13: 3199–3206. Published online 2019 Sep 10. doi: 10.2147/DDDT.S214918

PMCID:: PMC6751335

Abstract Article PDF–2.2M

Select item 65709289.

The p52 isoform of SHC1 is a key driver of breast cancer initiation

Kevin D. Wright, Bradley S. Miller, Sarah El-Meanawy, Shirng-Wern Tsaih, Anjishnu Banerjee, Aron M. Geurts, Yuri Sheinin, Yunguang Sun, Balaraman Kalyanaraman, Hallgeir Rui, Michael J. Flister, Andrey Sorokin

Breast Cancer Res. 2019; 21: 74. Published online 2019 Jun 15. doi: 10.1186/s13058-019-1155-7

PMCID:: PMC6570928

Abstract Article PDF–7.1M

Select item 619834710.

Inactivation of p66Shc Decreases Afferent Arteriolar K_ATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats

Bradley S. Miller, Shoshana R. Blumenthal, Alexey Shalygin, Kevin D. Wright, Alexander Staruschenko, John D. Imig, Andrey Sorokin

Diabetes. 2018 Nov; 67(11): 2206–2212. Published online 2018 Aug 21. doi: 10.2337/db18-0308

PMCID:: PMC6198347

Abstract Article PDF–1.2M

Select item 574891011.

ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies

Claire E. Martin, Kelly A. Petersen, Lamine Aoudjit, Manali Tilak, Vera Eremina, W. Rod Hardy, Susan E. Quaggin, Tomoko Takano, Nina Jones

J Am Soc Nephrol. 2018 Jan; 29(1): 92–103. Published online 2017 Oct 10. doi: 10.1681/ASN.2017030285

PMCID:: PMC5748910

Abstract Article

Select item 553361312.

MicroRNA miR-27b Rescues Bone Marrow–Derived Angiogenic Cell Function and Accelerates Wound Healing in Type 2 Diabetes Mellitus

Jie-Mei Wang, Jun Tao, Dan-Dan Chen, Jing-Jing Cai, Kaikobad Irani, Qinde Wang, Hong Yuan, Alex F. Chen

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Jul 28.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1): 99–109. Published online 2013 Oct 31. doi: 10.1161/ATVBAHA.113.302104

PMCID:: PMC5533613

Abstract Article PDF–1.9M

Select item 493191413.

Temporal regulation of EGF signaling networks by the scaffold protein Shc1

Yong Zheng, Cunjie Zhang, David R. Croucher, Mohamed A. Soliman, Nicole St-Denis, Adrian Pasculescu, Lorne Taylor, Stephen A. Tate, Rod W. Hardy, Karen Colwill, Anna Yue Dai, Rick Bagshaw, James W. Dennis, Anne-Claude Gingras, Roger J. Daly, Tony Pawson

Nature. Author manuscript; available in PMC 2016 Jul 4.

Published in final edited form as: Nature. 2013 Jul 11; 499(7457): 166–171. doi: 10.1038/nature12308

PMCID:: PMC4931914

Abstract Article PDF–1.3M

Select item 492269714.

p66Shc regulates renal vascular tone in hypertension-induced nephropathy

Bradley Miller, Oleg Palygin, Victoriya A. Rufanova, Andrew Chong, Jozef Lazar, Howard J. Jacob, David Mattson, Richard J. Roman, Jan M. Williams, Allen W. Cowley, Jr., Aron M. Geurts, Alexander Staruschenko, John D. Imig, Andrey Sorokin

J Clin Invest. 2016 Jul 1; 126(7): 2533–2546. Published online 2016 Jun 6. doi: 10.1172/JCI75079

PMCID:: PMC4922697

Abstract Article PDF–2.3M

Select item 486059915.

The redox protein p66^shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss

A. R. Fetoni, S. L. M. Eramo, F. Paciello, R. Rolesi, D. Samengo, G. Paludetti, D. Troiani, G. Pani

Sci Rep. 2016; 6: 25450. Published online 2016 May 9. doi: 10.1038/srep25450

PMCID:: PMC4860599

Abstract Article PDF–2.4M

Select item 465074116.

Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease

W Shan, L Gao, W Zeng, Y Hu, G Wang, M Li, J Zhou, X Ma, X Tian, J Yao

Cell Death Dis. 2015 Jul; 6(7): e1833. Published online 2015 Jul 23. doi: 10.1038/cddis.2015.196

PMCID:: PMC4650741

Abstract Article PDF–2.8M

Select item 367683217.

TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

Vivek K. Gupta, Yuyi You, Veer Bala Gupta, Alexander Klistorner, Stuart L. Graham

Int J Mol Sci. 2013 May; 14(5): 10122–10142. Published online 2013 May 13. doi: 10.3390/ijms140510122

PMCID:: PMC3676832

Abstract Article PDF–452K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 291166119.

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1

Adrian Mehlitz, Sebastian Banhart, André P. Mäurer, Alexis Kaushansky, Andrew G. Gordus, Julia Zielecki, Gavin MacBeath, Thomas F. Meyer

J Cell Biol. 2010 Jul 12; 190(1): 143–157. doi: 10.1083/jcb.200909095

PMCID:: PMC2911661

Abstract Article PDF–3.2M

Select item 286919620.

Essential Role of the Redox-Sensitive Kinase p66^shc in Determining Energetic and Oxidative Status and Cell Fate in Neuronal Preconditioning

Jacquelynn E. Brown, Stephanie L. H. Zeiger, Jane C. Hettinger, Joshua D. Brooks, Benjamin Holt, Jason D. Morrow, Erik S. Musiek, Ginger Milne, BethAnn McLaughlin

J Neurosci. 2010 Apr 14; 30(15): 5242–5252. doi: 10.1523/JNEUROSCI.6366-09.2010