PMC Links for GEO Profiles (Select 119209418) - PMC

Select item 63001061.

SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice

Karthik M. Kodigepalli, Minghua Li, Serena Bonifati, Amanda R. Panfil, Patrick L. Green, Shan-Lu Liu, Li Wu

Cell Cycle. 2018; 17(23): 2564–2576. Published online 2018 Dec 4. doi: 10.1080/15384101.2018.1550955

PMCID:: PMC6300106

Select item 59489752.

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation

Eddy Sanchai Thientosapol, Daniel Bosnjak, Timothy Durack, Igor Stevanovski, Michelle van Geldermalsen, Jeff Holst, Zeenat Jahan, Caitlin Shepard, Wolfgang Weninger, Baek Kim, Robert Brink, Christopher J. Jolly

Proc Natl Acad Sci U S A. 2018 May 8; 115(19): 4921–4926. Published online 2018 Apr 18. doi: 10.1073/pnas.1719771115

PMCID:: PMC5948975

Abstract Article PDF–803K

Select item 57889163.

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

Olga Buzovetsky, Chenxiang Tang, Kirsten M. Knecht, Jenna M. Antonucci, Li Wu, Xiaoyun Ji, Yong Xiong

Nat Commun. 2018; 9: 411. Published online 2018 Jan 29. doi: 10.1038/s41467-017-02783-8

PMCID:: PMC5788916

Abstract Article PDF–1.8M

Select item 56606234.

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

Vera Rocha-Perugini, Henar Suárez, Susana Álvarez, Soraya López-Martín, Gina M. Lenzi, Felipe Vences-Catalán, Shoshana Levy, Baek Kim, María A. Muñoz-Fernández, Francisco Sánchez-Madrid, Maria Yáñez-Mó

Nat Microbiol. Author manuscript; available in PMC 2018 Mar 4.

Published in final edited form as: Nat Microbiol. 2017 Nov; 2(11): 1513–1522. Published online 2017 Sep 4. doi: 10.1038/s41564-017-0019-0

PMCID:: PMC5660623

Abstract Article PDF–2.1M

Select item 55765765.

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu

Cell Rep. Author manuscript; available in PMC 2017 Aug 30.

Published in final edited form as: Cell Rep. 2017 Aug 22; 20(8): 1921–1935. doi: 10.1016/j.celrep.2017.08.008

PMCID:: PMC5576576

Abstract Article PDF–2.2M

Select item 52476416.

A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse

Nicolin Bloch, Sabine Gläsker, Poojitha Sitaram, Henning Hofmann, Caitlin N. Shepard, Megan L. Schultz, Baek Kim, Nathaniel R. Landau

J Biol Chem. 2017 Jan 20; 292(3): 1068–1080. Published online 2016 Dec 5. doi: 10.1074/jbc.M116.743740

PMCID:: PMC5247641

Abstract Article PDF–2.7M

Select item 48076557.

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

Rayk Behrendt, Tina Schumann, Alexander Gerbaulet, Laura A. Nguyen, Nadja Schubert, Dimitra Alexopoulou, Ursula Berka, Stefan Lienenklaus, Katrin Peschke, Kathrin Gibbert, Sabine Wittmann, Dirk Lindemann, Siegfried Weiss, Andreas Dahl, Ronald Naumann, Ulf Dittmer, Baek Kim, Werner Mueller, Thomas Gramberg, Axel Roers

Cell Rep. Author manuscript; available in PMC 2016 Mar 25.

Published in final edited form as: Cell Rep. 2013 Aug 29; 4(4): 689–696. Published online 2013 Aug 22. doi: 10.1016/j.celrep.2013.07.037

PMCID:: PMC4807655

Abstract Article PDF–666K

Select item 46462918.

Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592

Chenxiang Tang, Xiaoyun Ji, Li Wu, Yong Xiong

J Biol Chem. 2015 Oct 30; 290(44): 26352–26359. Published online 2015 Aug 20. doi: 10.1074/jbc.M115.677435

PMCID:: PMC4646291

Abstract Article PDF–1.6M

Select item 43186849.

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

Jeongmin Ryoo, Jongsu Choi, Changhoon Oh, Sungchul Kim, Minji Seo, Seokyoung Kim, Daekwan Seo, Jongkyu Kim, Tommy E. White, Alberto Brandariz-Nunez, Felipe Diaz-Griffero, Cheol-Heui Yun, Joseph A. Hollenbaugh, Baek Kim, Daehyun Baek, Kwangseog Ahn

Nat Med. Author manuscript; available in PMC 2015 Feb 5.

Published in final edited form as: Nat Med. 2014 Aug; 20(8): 936–941. Published online 2014 Jul 20. doi: 10.1038/nm.3626

PMCID:: PMC4318684

Abstract Article PDF–1.4M

Select item 415450510.

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Gillian I Rice, Jacquelyn Bond, Aruna Asipu, Rebecca L Brunette, Iain W Manfield, Ian M Carr, Jonathan C Fuller, Richard M Jackson, Teresa Lamb, Tracy A Briggs, Manir Ali, Hannah Gornall, Lydia R Couthard, Alec Aeby, Simon P Attard-Montalto, Enrico Bertini, Christine Bodemer, Knut Brockmann, Louise A Brueton, Peter C Corry, Isabelle Desguerre, Elisa Fazzi, Angels Garcia Cazorla, Blanca Gener, Ben C J Hamel, Arvid Heiberg, Matthew Hunter, Marjo S van der Knaap, Ram Kumar, Lieven Lagae, Pierre G Landrieu, Charles M Lourenco, Daphna Marom, Michael F McDermott, William van der Merwe, Simona Orcesi, Julie S Prendiville, Magnhild Rasmussen, Stavit A Shalev, Doriette M Soler, Marwan Shinawi, Ronen Spiegel, Tiong Y Tan, Adeline Vanderver, Emma L Wakeling, Evangeline Wassmer, Elizabeth Whittaker, Pierre Lebon, Daniel B Stetson, David T Bonthron, Yanick J Crow

Nat Genet. Author manuscript; available in PMC 2014 Sep 4.

Published in final edited form as: Nat Genet. 2009 Jul; 41(7): 829–832. Published online 2009 Jun 14. doi: 10.1038/ng.373

PMCID:: PMC4154505

Abstract Article PDF–851K

Select item 386463711.

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

Tommy E. White, Alberto Brandariz-Nuñez, Jose Carlos Valle-Casuso, Sarah Amie, Laura Anh Nguyen, Baek Kim, Marina Tuzova, Felipe Diaz-Griffero

Cell Host Microbe. Author manuscript; available in PMC 2014 Apr 17.

Published in final edited form as: Cell Host Microbe. 2013 Apr 17; 13(4): 10.1016/j.chom.2013.03.005. doi: 10.1016/j.chom.2013.03.005

PMCID:: PMC3864637

Abstract Article PDF–2.3M

Select item 383382812.

Mechanism of Allosteric Activation of SAMHD1 by dGTP

Xiaoyun Ji, Ying Wu, Junpeng Yan, Jennifer Mehrens, Haitao Yang, Maria DeLucia, Caili Hao, Angela M. Gronenborn, Jacek Skowronski, Jinwoo Ahn, Yong Xiong

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Nov; 20(11): 1304–1309. Published online 2013 Oct 20. doi: 10.1038/nsmb.2692

PMCID:: PMC3833828

Abstract Article PDF–1.7M

Select item 324352813.

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

Rebecca D. Powell, Paul J. Holland, Thomas Hollis, Fred W. Perrino

J Biol Chem. 2011 Dec 23; 286(51): 43596–43600. Published online 2011 Nov 8. doi: 10.1074/jbc.C111.317628

PMCID:: PMC3243528

Abstract Article PDF–447K

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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