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Select item 82350971.

LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium

Sujin Ju, Leejin Lim, Kwanhwan Wi, Changwon Park, Young-Jae Ki, Dong-Hyun Choi, Heesang Song

Int J Mol Sci. 2021 Jun; 22(12): 6581. Published online 2021 Jun 19. doi: 10.3390/ijms22126581

PMCID:: PMC8235097

Abstract Article PDF–7.4M

Select item 71634442.

Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction

Zhenxing Sun, Yuji Xie, Robert J. Lee, Yihan Chen, Qiaofeng Jin, Qing Lv, Jing Wang, Yali Yang, Yuman Li, Yu Cai, Rui Wang, Zhengyang Han, Li Zhang, Mingxing Xie

Theranostics. 2020; 10(11): 4967–4982. Published online 2020 Apr 6. doi: 10.7150/thno.43233

Correction in:: Theranostics. 2022; 12(6): 2637–2638.

PMCID:: PMC7163444

Abstract Article PDF–3.2M

Select item 70758683.

Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-κB-dependent mechanism

Hao Chen, Haifeng Zhang, Yue Zheng, Xiaohui Min, Yujun Luo, Weijie Zhou, Faxin Ma, Jinliang Li, Quan Lu, Chen Zhang, Huihua Cai, Weihong Sha

Cell Death Dis. 2020 Mar; 11(3): 188. Published online 2020 Mar 16. doi: 10.1038/s41419-020-2378-3

PMCID:: PMC7075868

Abstract Article PDF–6.7M

Select item 69696514.

Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury

Ying Xiong, Yun Xia, Jiangtao Deng, Xuetao Yan, Jianjuan Ke, Jia Zhan, Zongze Zhang, Yanlin Wang

Oxid Med Cell Longev. 2020; 2020: 4909103. Published online 2020 Jan 4. doi: 10.1155/2020/4909103

PMCID:: PMC6969651

Abstract Article PDF–3.3M

Select item 64042825.

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

Subramanian Rajagopalan, Anand Rane, Shankar J. Chinta, Julie K. Andersen

J Neurosci. 2016 Jan 27; 36(4): 1086–1095. doi: 10.1523/JNEUROSCI.3117-15.2016

PMCID:: PMC6404282

Abstract Article PDF–2.7M

Select item 58572526.

Hsp90 Co-chaperone p23 Contributes to Dopaminergic Mitochondrial Stress via Stabilization of PHD2: Implications for Parkinson’s disease

Anand Rane, Subramanian Rajagopalan, Manuj Ahuja, Bobby Thomas, Shankar J. Chinta, Julie K. Andersen

Neurotoxicology. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Neurotoxicology. 2018 Mar; 65: 166–173. Published online 2018 Feb 20. doi: 10.1016/j.neuro.2018.02.012

PMCID:: PMC5857252

Abstract Article PDF–1.3M

Select item 56964827.

Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells

Junping Hu, Weili Wang, Fan Zhang, Pin-Lan Li, Krishna M. Boini, Fan Yi, Ningjun Li

Sci Rep. 2017; 7: 15878. Published online 2017 Nov 20. doi: 10.1038/s41598-017-15972-8

PMCID:: PMC5696482

Abstract Article PDF–2.3M

Select item 52665508.

Whole Genome Survey of Copy Number Variation in the Spontaneously Hypertensive Rat: Relationship to Quantitative Trait Loci, Gene Expression and Blood Pressure

Fadi J Charchar, Michael Kaiser, Andrew J Bingham, Nina Fotinatos, Fahima Ahmady, Maciej Tomaszewski, Nilesh J Samani

Hypertension. Author manuscript; available in PMC 2017 Jan 25.

Published in final edited form as: Hypertension. 2010 May; 55(5): 1231–1238. Published online 2010 Mar 15. doi: 10.1161/HYPERTENSIONAHA.109.141663

PMCID:: PMC5266550

Abstract Article PDF–645K

Select item 48913049.

Class I and IIa HDACs mediate HIF-1α stability through PHD2-dependent mechanism while HDAC6, a class IIb member, promotes HIF-1α transcriptional activity in nucleus pulposus cells of the intervertebral disc

Zachary R. Schoepflin, Irving M. Shapiro, Makarand V. Risbud

J Bone Miner Res. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: J Bone Miner Res. 2016 Jun; 31(6): 1287–1299. Published online 2016 Mar 15. doi: 10.1002/jbmr.2787

PMCID:: PMC4891304

Abstract Article PDF–2.4M

Select item 480585610.

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Inmaculada Segura, Christian Lange, Ellen Knevels, Anastasiya Moskalyuk, Rocco Pulizzi, Guy Eelen, Thibault Chaze, Cicerone Tudor, Cyril Boulegue, Matthew Holt, Dirk Daelemans, Mariette Matondo, Bart Ghesquière, Michele Giugliano, Carmen Ruiz de Almodovar, Mieke Dewerchin, Peter Carmeliet

Cell Rep. 2016 Mar 22; 14(11): 2653–2667. Published online 2016 Mar 10. doi: 10.1016/j.celrep.2016.02.047

PMCID:: PMC4805856

Abstract Article

Select item 435813911.

Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus

Jun Li, Wen Yuan, Shuai Jiang, Wei Ye, Hao Yang, Irving M. Shapiro, Makarand V. Risbud

J Biol Chem. 2015 Mar 13; 290(11): 7195–7207. Published online 2015 Jan 29. doi: 10.1074/jbc.M114.611483

PMCID:: PMC4358139

Abstract Article PDF–1.3M

Select item 397368712.

Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

Andrew S. Zimmermann, Shane D. Morrison, Michael S. Hu, Shuli Li, Allison Nauta, Michael Sorkin, Nathaniel P. Meyer, Graham G. Walmsley, Zeshaan N. Maan, Denise A. Chan, Geoffrey C. Gurtner, Amato J. Giaccia, Michael T. Longaker

PLoS One. 2014; 9(4): e93373. Published online 2014 Apr 2. doi: 10.1371/journal.pone.0093373

PMCID:: PMC3973687

Abstract Article PDF–2.4M

Select item 384863213.

Silencing of HIF Prolyl-Hydroxylase 2 Gene in the Renal Medulla Attenuates Salt-Sensitive Hypertension in Dahl S Rats

Qing Zhu, Junping Hu, Wei-Qing Han, Fan Zhang, Pin-Lan Li, Zhengchao Wang, Ningjun Li

Am J Hypertens. 2014 Jan; 27(1): 107–113. Published online 2013 Nov 4. doi: 10.1093/ajh/hpt207

PMCID:: PMC3848632

Abstract Article PDF–896K

Select item 383710514.

A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism

Patrick R. Arsenault, Fei Pei, Rebecca Lee, Heddy Kerestes, Melanie J. Percy, Brian Keith, M. Celeste Simon, Terence R. J. Lappin, Tejvir S. Khurana, Frank S. Lee

J Biol Chem. 2013 Nov 22; 288(47): 33571–33584. Published online 2013 Oct 11. doi: 10.1074/jbc.M113.482364

PMCID:: PMC3837105

Abstract Article PDF–3.6M

Select item 382297515.

Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes

Hong Yan, Dong-Xia Zhang, Xiaohua Shi, Qiong Zhang, Yue-Sheng Huang

J Cell Mol Med. 2012 Sep; 16(9): 2049–2059. Published online 2012 Aug 23. doi: 10.1111/j.1582-4934.2011.01500.x

PMCID:: PMC3822975

Abstract Article PDF–444K

Select item 363110916.

Hypoxia-inducible Factor Prolyl-hydroxylase-2 Mediates Transforming Growth Factor Beta 1-induced Epithelial-mesenchymal Transition In Renal Tubular Cells

Wei-Qing Han, Qing Zhu, Junping Hu, Pin-Lan Li, Fan Zhang, Ningjun Li

Biochim Biophys Acta. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Biochim Biophys Acta. 2013 Jun; 1833(6): 1454–1462. Published online 2013 Mar 1. doi: 10.1016/j.bbamcr.2013.02.029

PMCID:: PMC3631109

Abstract Article PDF–1.1M

Select item 346134917.

Overexpression of HIF Prolyl-Hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension

Qing Zhu, Miao Liu, Wei-Qing Han, Pin-Lan Li, Zhengchao Wang, Ningjun Li

J Cell Mol Med. 2012 Nov; 16(11): 2701–2707. Published online 2012 Oct 29. doi: 10.1111/j.1582-4934.2012.01590.x

PMCID:: PMC3461349

Abstract Article PDF–220K

Select item 324894018.

Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene

Elena Albiero, Marco Ruggeri, Stefania Fortuna, Silvia Finotto, Martina Bernardi, Domenico Madeo, Francesco Rodeghiero

Haematologica. 2012 Jan; 97(1): 123–127. doi: 10.3324/haematol.2010.039545

PMCID:: PMC3248940

Abstract Article PDF–765K

Select item 324892519.

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

Charline Ladroue, David Hoogewijs, Sophie Gad, Romain Carcenac, Federica Storti, Michel Barrois, Anne-Paule Gimenez-Roqueplo, Michel Leporrier, Nicole Casadevall, Olivier Hermine, Jean-Jacques Kiladjian, André Baruchel, Fadi Fakhoury, Brigitte Bressac-de Paillerets, Jean Feunteun, Nathalie Mazure, Jacques Pouysségur, Roland H. Wenger, Stéphane Richard, Betty Gardie

Haematologica. 2012 Jan; 97(1): 9–14. doi: 10.3324/haematol.2011.044644

PMCID:: PMC3248925

Abstract Article PDF–1.6M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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