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Select item 110573571.

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

Helka Gӧӧs, Christopher L. Fogarty, Biswajyoti Sahu, Vincent Plagnol, Kristiina Rajamӓki, Katariina Nurmi, Xiaonan Liu, Elisabet Einarsdottir, Annukka Jouppila, Tom Pettersson, Helena Vihinen, Kaarel Krjutskov, Pӓivi Saavalainen, Asko Jӓrvinen, Mari Muurinen, Dario Greco, Giovanni Scala, James Curtis, Dan Nordstrӧm, Robert Flaumenhaft, Outi Vaarala, Panu E. Kovanen, Salla Keskitalo, Annamari Ranki, Juha Kere, Markku Lehto, Luigi D. Notarangelo, Sergey Nejentsev, Kari K. Eklund, Markku Varjosalo, Jussi Taipale, Mikko R. J. Seppänen

J Allergy Clin Immunol. Author manuscript; available in PMC 2024 Apr 29.

Published in final edited form as: J Allergy Clin Immunol. 2019 Nov; 144(5): 1364–1376. Published online 2019 Jun 13. doi: 10.1016/j.jaci.2019.06.003

PMCID:: PMC11057357

Abstract Article PDF–1.6M

Select item 84802812.

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille

Cell Rep. 2021 Sep 21; 36(12): 109725. Published online 2021 Sep 21. doi: 10.1016/j.celrep.2021.109725

PMCID:: PMC8480281

Abstract Article

Select item 82203913.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 80090484.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 77843085.

The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis

Jin Liu, Gu Weiling, Li Xueqin, Xie Liang, Wang Linhong, Chen Zhongwen

Environ Health Prev Med. 2021; 26: 2. Published online 2021 Jan 4. doi: 10.1186/s12199-020-00920-2

PMCID:: PMC7784308

Abstract Article PDF–1.5M

Select item 74616966.

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants

Justin B. Miller, Elizabeth Ward, Lyndsay A. Staley, Jeffrey Stevens, Craig C Teerlink, Justina P. Tavana, Matthew Cloward, Madeline Page, Louisa Dayton, Alzheimer’s Disease Genetics Consortium, Lisa A. Cannon-Albright, John S.K. Kauwe

Neurobiol Dis. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Neurobiol Dis. 2020 Sep; 143: 104972. Published online 2020 Jun 21. doi: 10.1016/j.nbd.2020.104972

PMCID:: PMC7461696

Abstract Article PDF–1.7M

Select item 73220677.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 72829478.

Loss of myeloid‐specific lamin A/C drives lung metastasis through Gfi‐1 and C/EBPε‐mediated granulocytic differentiation

Hiroki Ishii, Woo‐Yong Park, Jaeyoung So, Skyler Kuhn, Vishal N. Koparde, Yanli Pang, Tim F. Greten, M. Christine Hollander, Li Yang

Mol Carcinog. 2020 Jul; 59(7): 679–690. Published online 2020 Jan 7. doi: 10.1002/mc.23147

PMCID:: PMC7282947

Abstract Article PDF–3.5M

Select item 65536399.

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

Sam A. Jamieson, Zheng Ruan, Abigail E. Burgess, Jack R. Curry, Hamish D. McMillan, Jodi L. Brewster, Anita K. Dunbier, Alison D. Axtman, Natarajan Kannan, Peter D. Mace

Sci Signal. Author manuscript; available in PMC 2019 Jun 6.

Published in final edited form as: Sci Signal. 2018 Sep 25; 11(549): eaau0597. Published online 2018 Sep 25. doi: 10.1126/scisignal.aau0597

PMCID:: PMC6553639

Abstract Article PDF–1.4M

Select item 654932210.

CEBPE expression is an independent prognostic factor for acute myeloid leukemia

Kening Li, Yuxin Du, Dong-Qing Wei, Fang Zhang

J Transl Med. 2019; 17: 188. Published online 2019 Jun 4. doi: 10.1186/s12967-019-1944-x

PMCID:: PMC6549322

Abstract Article PDF–2.7M

Select item 632705011.

Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism

James B. Studd, Minjun Yang, Zhenhua Li, Jayaram Vijayakrishnan, Yi Lu, Allen Eng-Juh Yeoh, Kajsa Paulsson, Richard S. Houlston

Leukemia. 2019; 33(1): 1–14. Published online 2018 Jul 6. doi: 10.1038/s41375-018-0184-z

PMCID:: PMC6327050

Abstract Article PDF–1.8M

Select item 606803212.

CARD10, a CEBPE target involved in granulocytic differentiation

Pavithra Shyamsunder, Haresh Sankar, Anand Mayakonda, Lin Han, Hazimah Binte Mohd Nordin, Teoh Weoi Woon, Mahalakshmi Shanmugasundaram, Pushkar Dakle, Vikas Madan, H. Phillip Koeffler

Haematologica. 2018 Aug; 103(8): 1269–1277. Prepublished online 2018 May 17. doi: 10.3324/haematol.2018.190280

PMCID:: PMC6068032

Abstract Article PDF–1.9M

Select item 596862413.

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos

Deepti Jain, Chani J. Hodonsky, Ursula M. Schick, Jean V. Morrison, Sharon Minnerath, Lisa Brown, Claudia Schurmann, Yongmei Liu, Paul L. Auer, Cecelia A. Laurie, Kent D. Taylor, Brian L. Browning, George Papanicolaou, Sharon R. Browning, Ruth J. F. Loos, Kari E. North, Bharat Thyagarajan, Cathy C. Laurie, Timothy A. Thornton, Tamar Sofer, Alexander P. Reiner

Hum Mol Genet. 2017 Mar 15; 26(6): 1193–1204. Published online 2017 Feb 1. doi: 10.1093/hmg/ddx024

PMCID:: PMC5968624

Abstract Article PDF–600K

Select item 549662614.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Pedro M. Quirós, Miguel A. Prado, Nicola Zamboni, Davide D’Amico, Robert W. Williams, Daniel Finley, Steven P. Gygi, Johan Auwerx

J Cell Biol. 2017 Jul 3; 216(7): 2027–2045. doi: 10.1083/jcb.201702058

PMCID:: PMC5496626

Abstract Article PDF–3.1M

Select item 534985115.

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

José A Rodríguez-Martínez, Aaron W Reinke, Devesh Bhimsaria, Amy E Keating, Aseem Z Ansari

eLife. 2017; 6: e19272. Published online 2017 Feb 10. doi: 10.7554/eLife.19272

PMCID:: PMC5349851

Abstract Article PDF–2.1M

Select item 510494116.

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells

Christian H. Gabriel, Fridolin Gross, Martin Karl, Heike Stephanowitz, Anna Floriane Hennig, Melanie Weber, Stefanie Gryzik, Ivo Bachmann, Katharina Hecklau, Jürgen Wienands, Johannes Schuchhardt, Hanspeter Herzel, Andreas Radbruch, Eberhard Krause, Ria Baumgrass

J Biol Chem. 2016 Nov 11; 291(46): 24172–24187. Published online 2016 Sep 16. doi: 10.1074/jbc.M116.739326

PMCID:: PMC5104941

Abstract Article PDF–3.6M

Select item 491554817.

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

Elli Papaemmanuil, Fay J Hosking, Jayaram Vijayakrishnan, Amy Price, Bianca Olver, Eammon Sheridan, Sally E Kinsey, Tracy Lightfoot, Eve Roman, Julie A E Irving, James M. Allan, Ian P Tomlinson, Malcolm Taylor, Mel Greaves, Richard S Houlston

Nat Genet. Author manuscript; available in PMC 2016 Jun 21.

Published in final edited form as: Nat Genet. 2009 Sep; 41(9): 1006–1010. Published online 2009 Aug 16. doi: 10.1038/ng.430

PMCID:: PMC4915548

Abstract Article PDF–614K

Select item 486916918.

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program

Jing Xu, Li Li, Jie Xiong, Aaron denDekker, Andrew Ye, Hacer Karatas, Liu Liu, He Wang, Zhaohui S Qin, Shaomeng Wang, Yali Dou

Cell Discov. 2016; 2: 16008. Published online 2016 May 17. doi: 10.1038/celldisc.2016.8

PMCID:: PMC4869169

Abstract Article PDF–2.0M

Select item 479441219.

A Functional Polymorphism in the CEBPE Gene Promoter Influences Acute Lymphoblastic Leukemia Risk through Interaction with the Hematopoietic Transcription Factor Ikaros

Joseph L. Wiemels, Adam J. de Smith, Jianqiao Xiao, Seung-Tae Lee, Marcus O. Muench, Marina E. Fomin, Mi Zhou, Helen M. Hansen, Amanda Termuhlen, Catherine Metayer, Kyle M. Walsh

Leukemia. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Leukemia. 2016 May; 30(5): 1194–1197. Published online 2015 Sep 16. doi: 10.1038/leu.2015.251

PMCID:: PMC4794412

Article PDF–565K

Select item 450423420.

Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early life infections with the risk of acute lymphoblastic leukemia in Hispanic children

Ling-I Hsu, Anand P. Chokkalingam, Farren B.S. Briggs, Kyle Walsh, Vonda Crouse, Cecilia Fu, Metayer, Joseph L. Wiemels, Lisa F. Barcellos, Patricia A. Buffler

Cancer Causes Control. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Cancer Causes Control. 2015 Apr; 26(4): 609–619. Published online 2015 Mar 12. doi: 10.1007/s10552-015-0550-3

PMCID:: PMC4504234

Abstract Article PDF–409K

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