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Items: 1 to 20 of 58

1.
Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models
Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan
J Biomed Sci. 2024; 31: 24. Published online 2024 Feb 23. doi: 10.1186/s12929-024-01010-z
PMCID:
PMC10893700
AbstractArticlePDF–14M
2.
CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress
Xuanzhuo Liu, Fang Wang, Xinman Fan, Mingyi Chen, Xiaoxin Xu, Qiuhong Xu, Huili Zhu, Anding Xu, Mahmoud A. Pouladi, Xiaohong Xu
Cell Death Dis. 2024 Feb; 15(2): 126. Published online 2024 Feb 10. doi: 10.1038/s41419-024-06523-x
PMCID:
PMC10858906
AbstractArticlePDF–9.2M
3.
Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity
Jumee Kim, Eun-Ji Kwon, Yun-Jeong Kim, Dayeon Kim, Yoon-Ze Shin, Dayeon Gil, Jung-Hyun Kim, Hyoung Doo Shin, Lyoung Hyo Kim, Mi-Ok Lee, Young-Hyun Go, Hyuk-Jin Cha
Cell Mol Life Sci. 2024 Dec; 81(1): 38. Published online 2024 Jan 12. doi: 10.1007/s00018-023-05060-8
PMCID:
PMC10787008
AbstractArticlePDF–15M
4.
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188
PMCID:
PMC9881136
AbstractArticlePDF–4.4M
5.
Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth
David J. Wisniewski, Mariya S. Liyasova, Soumya Korrapati, Xu Zhang, Shashikala Ratnayake, Qingrong Chen, Samuel F. Gilbert, Alexis Catalano, Donna Voeller, Daoud Meerzaman, Udayan Guha, Natalie Porat-Shliom, Christina M. Annunziata, Stanley Lipkowitz
J Biol Chem. 2023 Jan; 299(1): 102766. Published online 2022 Dec 5. doi: 10.1016/j.jbc.2022.102766
PMCID:
PMC9823131
AbstractArticlePDF–2.5M
6.
Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic steatohepatitis via Notch/osteopontin signaling
Yue Li, Wenjing Xiu, Jingwen Xu, Xiangmei Chen, Guangyan Wang, Jinjie Duan, Lei Sun, Ben Liu, Wen Xie, Guangyin Pu, Qi Wang, Chunjiong Wang
JCI Insight. 2022 Dec 8; 7(23): e162402. Published online 2022 Dec 8. doi: 10.1172/jci.insight.162402
PMCID:
PMC9746920
AbstractArticlePDF–5.6M
7.
Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition
Ilaria Iacobucci, Vittoria Monaco, Luisa Canè, Francesca Bibbò, Valentina Cioffi, Flora Cozzolino, Alfredo Guarino, Massimo Zollo, Maria Monti
Front Mol Biosci. 2022; 9: 975570. Published online 2022 Sep 26. doi: 10.3389/fmolb.2022.975570
PMCID:
PMC9550266
AbstractArticlePDF–2.5M
8.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
9.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
10.
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2
Mai K Nguyen, Kevin McAvoy, Szu-Chi Liao, Zak Doric, Iris Lo, Huihui Li, Giovanni Manfredi, Ken Nakamura
Hum Mol Genet. 2022 May 1; 31(9): 1500–1518. Published online 2021 Nov 15. doi: 10.1093/hmg/ddab329
PMCID:
PMC9071413
AbstractArticlePDF–2.9M
11.
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response
Yu Ruan, Jiaqiao Hu, Yaping Che, Yanyan Liu, Zhenhuan Luo, Jin Cheng, Qi Han, He He, Qinghua Zhou
Cell Death Dis. 2022 Feb; 13(2): 156. Published online 2022 Feb 16. doi: 10.1038/s41419-022-04602-5
PMCID:
PMC8850591
AbstractArticlePDF–11M
12.
CHCHD10 is involved in the development of Parkinson’s disease caused by CHCHD2 loss-of-function mutation p.T61I
Chengyuan Mao, Herui Wang, Haiyang Luo, Shuyu Zhang, Huisha Xu, Shuo Zhang, Jared Rosenblum, Zhilei Wang, Qi Zhang, Mibo Tang, Matthew J. Shepard, Xiang Wang, Yaohe Wang, Zhengping Zhuang, Changhe Shi, Yuming Xu
Neurobiol Aging. Author manuscript; available in PMC 2021 Jul 29.
Published in final edited form as: Neurobiol Aging. 2019 Mar; 75: 38–41. Published online 2018 Oct 23. doi: 10.1016/j.neurobiolaging.2018.10.020
PMCID:
PMC8320701
AbstractArticlePDF–917K
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson’s disease
Xiaodan Liu, Qilong Wang, Ying Yang, Tessandra Stewart, Min Shi, David Soltys, Genliang Liu, Eric Thorland, Eugene M. Cilento, Yiran Hou, Zongran Liu, Tao Feng, Jing Zhang
Acta Neuropathol Commun. 2021; 9: 37. Published online 2021 Mar 8. doi: 10.1186/s40478-021-01133-6
PMCID:
PMC7941904
AbstractArticlePDF–8.2M
15.
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators
Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele
PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975
PMCID:
PMC7758050
AbstractArticlePDF–4.2M
16.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms
Siddhesh Aras, Neeraja Purandare, Stephanie Gladyck, Mallika Somayajulu-Nitu, Kezhong Zhang, Douglas C. Wallace, Lawrence I. Grossman
Proc Natl Acad Sci U S A. 2020 Dec 15; 117(50): 32056–32065. Published online 2020 Nov 30. doi: 10.1073/pnas.2005877117
Correction in:
Proc Natl Acad Sci U S A. 2021 Feb 16; 118(7): e2100262118.
PMCID:
PMC7749287
AbstractArticlePDF–1.4M
17.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations
Yi-Ting Liu, Xiaoping Huang, Diana Nguyen, Mario K Shammas, Beverly P Wu, Eszter Dombi, Danielle A Springer, Joanna Poulton, Shiori Sekine, Derek P Narendra
Hum Mol Genet. 2020 Jun 3; 29(9): 1547–1567. Published online 2020 Apr 27. doi: 10.1093/hmg/ddaa077
PMCID:
PMC7268789
AbstractArticlePDF–2.9M
18.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
19.
STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency
Yuyan Wang, Shujuan Du, Caixia Zhu, Chong Wang, Nuoya Yu, Ziqi Lin, Jin Gan, Yi Guo, Xinxin Huang, Yuping He, Erle Robertson, Di Qu, Fang Wei, Qiliang Cai
PLoS Pathog. 2020 Mar; 16(3): e1008447. Published online 2020 Mar 16. doi: 10.1371/journal.ppat.1008447
PMCID:
PMC7105294
AbstractArticlePDF–4.4M
20.
CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression
Xin Yin, Jinghua Xia, Ying Sun, Zhipei Zhang
BMC Pulm Med. 2020; 20: 40. Published online 2020 Feb 13. doi: 10.1186/s12890-020-1079-0
PMCID:
PMC7020603
AbstractArticlePDF–2.9M

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