PMC Links for GEO Profiles (Select 132351519) - PMC

Purushotham Selvakumar, Ana I. Fernández-Mariño, Nandish Khanra, Changhao He, Alice J. Paquette, Bing Wang, Ruiqi Huang, Vaughn V. Smider, William J. Rice, Kenton J. Swartz, Joel R. Meyerson

Nat Commun. 2022; 13: 3854. Published online 2022 Jul 4. doi: 10.1038/s41467-022-31285-5

PMCID:: PMC9253088

Abstract Article PDF–5.1M

Select item 91063034.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 89525075.

Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells

Veronika Sebestyén, Éva Nagy, Gábor Mocsár, Julianna Volkó, Orsolya Szilágyi, Ádám Kenesei, György Panyi, Katalin Tóth, Péter Hajdu, György Vámosi

Int J Mol Sci. 2022 Mar; 23(6): 3313. Published online 2022 Mar 18. doi: 10.3390/ijms23063313

PMCID:: PMC8952507

Abstract Article PDF–2.8M

Select item 88125166.

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

Anu Tyagi, Tofayel Ahmed, Shi Jian, Saumya Bajaj, Seow Theng Ong, Stephanie Shee Min Goay, Yue Zhao, Igor Vorobyov, Changlin Tian, K. George Chandy, Shashi Bhushan

Proc Natl Acad Sci U S A. 2022 Feb 1; 119(5): e2113536119. Published online 2022 Jan 28. doi: 10.1073/pnas.2113536119

PMCID:: PMC8812516

Abstract Article PDF–2.4M

Select item 82489867.

A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

Jesusa Capera, Mireia Pérez-Verdaguer, Roberta Peruzzo, María Navarro-Pérez, Juan Martínez-Pinna, Armando Alberola-Die, Andrés Morales, Luigi Leanza, Ildiko Szabó, Antonio Felipe

eLife. 2021; 10: e69099. Published online 2021 Jul 1. doi: 10.7554/eLife.69099

PMCID:: PMC8248986

Abstract Article PDF–4.2M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80276669.

Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism

Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts

Cell Death Dis. 2021 Apr; 12(4): 372. Published online 2021 Apr 7. doi: 10.1038/s41419-021-03627-6

PMCID:: PMC8027666

Abstract Article PDF–4.1M

Select item 798037810.

Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease

Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, Srikant Rangaraju

Proc Natl Acad Sci U S A. 2021 Mar 16; 118(11): e2013545118. Published online 2021 Mar 1. doi: 10.1073/pnas.2013545118

PMCID:: PMC7980378

Abstract Article PDF–4.7M

Select item 741006411.

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease

Souvarish Sarkar, Hai M. Nguyen, Emir Malovic, Jie Luo, Monica Langley, Bharathi N. Palanisamy, Neeraj Singh, Sireesha Manne, Matthew Neal, Michelle Gabrielle, Ahmed Abdalla, Poojya Anantharam, Dharmin Rokad, Nikhil Panicker, Vikrant Singh, Muhammet Ay, Adhithiya Charli, Dilshan Harischandra, Lee-Way Jin, Huajun Jin, Srikant Rangaraju, Vellareddy Anantharam, Heike Wulff, Anumantha G. Kanthasamy

J Clin Invest. 2020 Aug 3; 130(8): 4195–4212. Published online 2020 Jun 29. doi: 10.1172/JCI136174

PMCID:: PMC7410064

Abstract Article PDF–18M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 699416013.

β1-Integrin– and K_V1.3 channel–dependent signaling stimulates glutamate release from Th17 cells

Katharina Birkner, Beatrice Wasser, Tobias Ruck, Carine Thalman, Dirk Luchtman, Katrin Pape, Samantha Schmaul, Lynn Bitar, Eva-Maria Krämer-Albers, Albrecht Stroh, Sven G. Meuth, Frauke Zipp, Stefan Bittner

J Clin Invest. 2020 Feb 3; 130(2): 715–732. Published online 2020 Jan 6. doi: 10.1172/JCI126381

PMCID:: PMC6994160

Abstract Article PDF–14M

Select item 678245014.

Neuronal Interleukin-16 (NIL-16): A Dual Function PDZ Domain Protein

Cornelia Kurschner, Michisuke Yuzaki

J Neurosci. 1999 Sep 15; 19(18): 7770–7780. doi: 10.1523/JNEUROSCI.19-18-07770.1999

PMCID:: PMC6782450

Abstract Article PDF–604K

Select item 627578515.

The influence of protons and zinc ions on the steady-state inactivation of Kv1.3 potassium channels

Andrzej Teisseyre, Jerzy W. Mozrzymas

Cell Mol Biol Lett. 2007 Apr; 12(2): 220–230. Published online 2006 Dec 12. doi: 10.2478/s11658-006-0067-6

PMCID:: PMC6275785

Summary PDF–399K

Select item 589752016.

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane

Orsolya Voros, Orsolya Szilagyi, András Balajthy, Sándor Somodi, Gyorgy Panyi, Péter Hajdu

Sci Rep. 2018; 8: 5937. Published online 2018 Apr 12. doi: 10.1038/s41598-018-24159-8

PMCID:: PMC5897520

Abstract Article PDF–2.7M

Select item 555729217.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533799319.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan

Nat Commun. 2017; 8: 14644. Published online 2017 Mar 1. doi: 10.1038/ncomms14644

PMCID:: PMC5337993

Abstract Article PDF–2.6M

Select item 513813820.

Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K⁺ current conducted by K_V1.3

Han Liu, Jianuo Liu, Enquan Xu, Guihua Tu, Minglei Guo, Shangdong Liang, Huangui Xiong

Neurobiol Dis. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: Neurobiol Dis. 2017 Jan; 97(Pt A): 1–10. Published online 2016 Nov 2. doi: 10.1016/j.nbd.2016.10.007

PMCID:: PMC5138138

Abstract Article PDF–3.6M

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