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Items: 1 to 20 of 33

1.
ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
Dhanunjay Mukhi, Lingzhi Li, Hongbo Liu, Tomohito Doke, Lakshmi P. Kolligundla, Eunji Ha, Konstantin Kloetzer, Amin Abedini, Sarmistha Mukherjee, Junnan Wu, Poonam Dhillon, Hailong Hu, Dongyin Guan, Katsuhiko Funai, Kahealani Uehara, Paul M. Titchenell, Joseph A. Baur, Kathryn E. Wellen, Katalin Susztak
J Clin Invest. 2024 Feb 15; 134(4): e172963. Published online 2023 Dec 5. doi: 10.1172/JCI172963
PMCID:
PMC10866669
AbstractArticlePDF–5.0M
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells
Dongwen Que, Feimei Kuang, Rui Kang, Daolin Tang, Jiao Liu
Sci Rep. 2023; 13: 1483. Published online 2023 Jan 27. doi: 10.1038/s41598-023-28261-4
PMCID:
PMC9883393
AbstractArticlePDF–1.9M
4.
Acetyl-coA Synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer
Zhijun Zhou, Yu Ren, Jingxuan Yang, Mingyang Liu, Xiuhui Shi, Wenyi Luo, Kar-Ming Fung, Chao Xu, Michael S. Bronze, Yuqing Zhang, Courtney W. Houchen, Min Li
Gastroenterology. Author manuscript; available in PMC 2023 Nov 1.
Published in final edited form as: Gastroenterology. 2022 Nov; 163(5): 1281–1293.e1. Published online 2022 Jun 28. doi: 10.1053/j.gastro.2022.06.058
PMCID:
PMC9613512
AbstractArticlePDF–3.0M
5.
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D’Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder, Mauricio J. Reginato
Oncogene. Author manuscript; available in PMC 2022 Aug 25.
Published in final edited form as: Oncogene. 2022 Apr; 41(14): 2122–2136. Published online 2022 Feb 22. doi: 10.1038/s41388-022-02237-6
PMCID:
PMC9410282
AbstractArticlePDF–1.3M
6.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
7.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
8.
Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements
Jason S. Nagati, Philippe H. Kobeissy, Minh Q. Nguyen, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia
J Biol Chem. 2021 Sep; 297(3): 101037. Published online 2021 Jul 31. doi: 10.1016/j.jbc.2021.101037
PMCID:
PMC8405932
AbstractArticlePDF–5.4M
9.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
10.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
11.
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer
Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanović, Katherine Murphy, Binbin Wang, Xintao Qiu, Jennifer E. Endress, Jaime Reyes, Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Tengfei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D’Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, X. Shirley Liu, Henry Long, Myles Brown, Jason S. Carroll, Joan S. Brugge, James Bradner, Franziska Michor, Kornelia Polyak
Mol Cell. Author manuscript; available in PMC 2021 Jun 18.
Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1096–1113.e8. Published online 2020 May 15. doi: 10.1016/j.molcel.2020.04.027
PMCID:
PMC7306005
AbstractArticlePDF–3.2M
12.
HIV latency is reversed by ACSS2-driven histone crotonylation
Guochun Jiang, Don Nguyen, Nancie M. Archin, Steven A. Yukl, Gema Méndez-Lagares, Yuyang Tang, Maher M. Elsheikh, George R. Thompson, III, Dennis J. Hartigan-O’Connor, David M. Margolis, Joseph K. Wong, Satya Dandekar
J Clin Invest. 2018 Mar 1; 128(3): 1190–1198. Published online 2018 Feb 19. doi: 10.1172/JCI98071
PMCID:
PMC5824862
AbstractArticlePDF–1.8M
13.
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells
Rui Chen, Min Xu, Jason Nagati, Joseph A. Garcia
PLoS One. 2017; 12(12): e0190241. Published online 2017 Dec 27. doi: 10.1371/journal.pone.0190241
PMCID:
PMC5744998
AbstractArticlePDF–12M
14.
Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy
Xinjian Li, Xu Qian, Zhimin Lu
Autophagy. 2017; 13(10): 1790–1791. Published online 2017 Aug 18. doi: 10.1080/15548627.2017.1349581
PMCID:
PMC5640193
AbstractArticlePDF–370K
15.
ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations
Sonam Dodhia, Katrina Celis, Alana Aylward, Yi Cai, Maria E. Fontana, Alberto Trespalacios, David C. Hoffman, Henry Ostos Alfonso, Sidney B. Eisig, Gloria H. Su, Wendy K. Chung, Joseph Haddad, Jr
Laryngoscope. Author manuscript; available in PMC 2018 Oct 1.
Published in final edited form as: Laryngoscope. 2017 Oct; 127(10): E336–E339. Published online 2017 May 23. doi: 10.1002/lary.26637
PMCID:
PMC5607083
AbstractArticlePDF–304K
16.
Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy
Xinjian Li, Willie Yu, Xu Qian, Yan Xia, Yanhua Zheng, Jong-Ho Lee, Wei Li, Jianxin Lyu, Ganesh Rao, Xiaochun Zhang, Chao-Nan Qian, Steven G Rozen, Tao Jiang, Zhimin Lu
Mol Cell. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: Mol Cell. 2017 Jun 1; 66(5): 684–697.e9. Published online 2017 May 25. doi: 10.1016/j.molcel.2017.04.026
PMCID:
PMC5521213
AbstractArticlePDF–1.4M
17.
ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection
Anna Vysochan, Arjun Sengupta, Aalim M. Weljie, James C. Alwine, Yongjun Yu
Proc Natl Acad Sci U S A. 2017 Feb 21; 114(8): E1528–E1535. Published online 2017 Feb 6. doi: 10.1073/pnas.1614268114
PMCID:
PMC5338361
AbstractArticlePDF–1.1M
18.
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst
Cell Rep. 2017 Jan 17; 18(3): 647–658. Published online 2017 Jan 17. doi: 10.1016/j.celrep.2016.12.055
PMCID:
PMC5276806
AbstractArticlePDF–3.8M
19.
Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth
Alexander J. Lakhter, James Hamilton, Raymond L. Konger, Nickolay Brustovetsky, Hal E. Broxmeyer, Samisubbu R. Naidu
J Biol Chem. 2016 Oct 14; 291(42): 21869–21879. Published online 2016 Aug 18. doi: 10.1074/jbc.M115.712166
PMCID:
PMC5063972
AbstractArticlePDF–2.3M
20.
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Nature. Author manuscript; available in PMC 2016 Sep 26.
Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877
PMCID:
PMC5036527
AbstractArticlePDF–4.7M

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