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Select item 114010341.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin

J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621

PMCID:: PMC11401034

Abstract Article PDF–5.4M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111156123.

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

Dong Gao, Ruipeng Wang, Bingfeng Li, Yongkang Yang, Zhonghe Zhai, Dan-Ying Chen

Cell Mol Life Sci. 2009 Aug; 66(15): 2573–2584. Published online 2009 Jun 12. doi: 10.1007/s00018-009-0059-6

PMCID:: PMC11115612

Abstract Article PDF–618K

Select item 111147094.

PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1

Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chung

Cell Mol Life Sci. 2012 Oct; 69(19): 3301–3315. Published online 2012 May 29. doi: 10.1007/s00018-012-1004-7

PMCID:: PMC11114709

Abstract Article PDF–896K

Select item 111132425.

The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE)

Jengmin Kang, Kwang Chul Chung

Cell Mol Life Sci. 2015 Jan; 72(1): 181–195. Published online 2014 Jun 20. doi: 10.1007/s00018-014-1665-5

PMCID:: PMC11113242

Abstract Article PDF–1.4M

Select item 111094836.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110241797.

TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin

Cell Death Dis. 2024 Apr; 15(4): 273. Published online 2024 Apr 17. doi: 10.1038/s41419-024-06654-1

PMCID:: PMC11024179

Abstract Article PDF–6.6M

Select item 108508188.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 106438899.

Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA

Grant R. Campbell, Pratima Rawat, Stephen A. Spector

J Innate Immun. 2023 Jan-Dec; 15(1): 96–106. Published online 2022 Jul 4. doi: 10.1159/000525292

PMCID:: PMC10643889

Abstract Article PDF–1.2M

Select item 1063829710.

USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1

Hongdian Zhang, Youming Han, Wanyi Xiao, Yongyin Gao, Zhilin Sui, Peng Ren, Fanbiao Meng, Peng Tang, Zhentao Yu

Cell Death Dis. 2023 Nov; 14(11): 730. Published online 2023 Nov 10. doi: 10.1038/s41419-023-06259-0

PMCID:: PMC10638297

Abstract Article PDF–4.8M

Select item 1062014211.

Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators

Mai A. Abd-Elmawla, Yumn A. Elsabagh, Nora M. Aborehab

Sci Rep. 2023; 13: 18790. Published online 2023 Nov 1. doi: 10.1038/s41598-023-45214-z

PMCID:: PMC10620142

Abstract Article PDF–2.2M

Select item 1044380612.

Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis

Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga

JCI Insight. 2023 Jul 24; 8(14): e165358. Published online 2023 Jul 24. doi: 10.1172/jci.insight.165358

PMCID:: PMC10443806

Abstract Article PDF–14M

Select item 1031846813.

The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection

Hua Yang, Constanza E. Espada, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Li Wu

J Biol Chem. 2023 Jun; 299(6): 104750. Published online 2023 Apr 24. doi: 10.1016/j.jbc.2023.104750

PMCID:: PMC10318468

Abstract Article PDF–4.9M

Select item 1025073014.

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination

Zhongbao Chen, Fengjiao Hu, Yalong Zhang, Long Zhang, Tianyu Wang, Chenyang Kong, Haochong Hu, Jiayu Guo, Qi Chen, Bo Yu, Yiting Liu, Jilin Zou, Jiangqiao Zhou, Tao Qiu

Front Immunol. 2023; 14: 1167667. Published online 2023 May 26. doi: 10.3389/fimmu.2023.1167667

PMCID:: PMC10250730

Abstract Article PDF–10M

Select item 1012291215.

SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1‐Dependent Manner

Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, Dewen Leng, Yang Li, Hongjie Shi, Dawei Deng, Kehan Ding, Chuan Liang, Jinping Liu

J Am Heart Assoc. 2023 Apr 4; 12(7): e028628. Published online 2023 Mar 28. doi: 10.1161/JAHA.122.028628

PMCID:: PMC10122912

Abstract Article PDF–25M

Select item 1007290616.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1007043817.

E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2

Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren, Liwen Yu, Qian Li, Yapeng Liu, Wenqian Qi, Yonghao Hou, Wenhai Sui, Guohai Su, Yun Zhang, Cheng Zhang, Meng Zhang

Cell Death Differ. 2023 Apr; 30(4): 966–978. Published online 2023 Jan 21. doi: 10.1038/s41418-023-01115-2

PMCID:: PMC10070438

Abstract Article PDF–11M

Select item 1002340618.

Emerging role of TAK1 in the regulation of skeletal muscle mass

Anirban Roy, Vihang A. Narkar, Ashok Kumar

Bioessays. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Bioessays. 2023 Apr; 45(4): e2300003. Published online 2023 Feb 15. doi: 10.1002/bies.202300003

PMCID:: PMC10023406

Abstract Article PDF–1.4M

Select item 972467119.

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen

EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839

PMCID:: PMC9724671

Abstract Article PDF–1.8M

Select item 970452720.

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401

PMCID:: PMC9704527

Abstract Article PDF–7.7M

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