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Select item 72473181.

Knock-in rats with homozygous PSEN1^L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43

Marc D. Tambini, Luciano D'Adamio

J Biol Chem. 2020 May 22; 295(21): 7442–7451. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.012542

PMCID:: PMC7247318

Abstract Article PDF–2.7M

Select item 67723702.

Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal Ischemia In Vivo and to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

Mark P. Mattson, Haiyan Zhu, Jin Yu, Mark S. Kindy

J Neurosci. 2000 Feb 15; 20(4): 1358–1364. doi: 10.1523/JNEUROSCI.20-04-01358.2000

PMCID:: PMC6772370

Abstract Article PDF–263K

Select item 67588623.

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Marcus A. Westerman, Deirdre Cooper-Blacketer, Ami Mariash, Linda Kotilinek, Takeshi Kawarabayashi, Linda H. Younkin, George A. Carlson, Steven G. Younkin, Karen H. Ashe

J Neurosci. 2002 Mar 1; 22(5): 1858–1867. doi: 10.1523/JNEUROSCI.22-05-01858.2002

PMCID:: PMC6758862

Abstract Article PDF–361K

Select item 67407804.

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

Gustavo Pigino, Gerardo Morfini, Alejandra Pelsman, Mark P. Mattson, Scott T. Brady, Jorge Busciglio

J Neurosci. 2003 Jun 1; 23(11): 4499–4508. doi: 10.1523/JNEUROSCI.23-11-04499.2003

PMCID:: PMC6740780

Abstract Article PDF–383K

Select item 67252095.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong

J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005

PMCID:: PMC6725209

Abstract Article PDF–351K

Select item 66728276.

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Tong Li, Hongjin Wen, Cory Brayton, Fiona M. Laird, Guojun Ma, Shiwen Peng, Lisa Placanica, T. C. Wu, Barbara J. Crain, Donald L. Price, Charles G. Eberhart, Philip C. Wong

J Neurosci. 2007 Oct 3; 27(40): 10849–10859. doi: 10.1523/JNEUROSCI.2152-07.2007

PMCID:: PMC6672827

Abstract Article PDF–665K

Select item 65791127.

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

Michael K. Lee, Hilda H. Slunt, Lee J. Martin, Gopal Thinakaran, Grace Kim, Samuel E. Gandy, Mary Seeger, Edward Koo, Donald L. Price, Sangram S. Sisodia

J Neurosci. 1996 Dec 1; 16(23): 7513–7525. doi: 10.1523/JNEUROSCI.16-23-07513.1996

PMCID:: PMC6579112

Abstract Article PDF–1.9M

Select item 59453148.

Presenilin PS1ΔE9 disrupts mobility of secretory organelles in rat astrocytes

Matjaž Stenovec, Saša Trkov Bobnar, Tina Smolič, Marko Kreft, Vladimir Parpura, Robert Zorec

Acta Physiol (Oxf) Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Acta Physiol (Oxf). 2018 Jun; 223(2): e13046. Published online 2018 Feb 19. doi: 10.1111/apha.13046

PMCID:: PMC5945314

Abstract Article PDF–2.3M

Select item 58950239.

Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease

Diana Klakotskaia, Cansu Agca, Rachel A. Richardson, Edward G. Stopa, Todd R. Schachtman, Yuksel Agca

PLoS One. 2018; 13(4): e0195469. Published online 2018 Apr 11. doi: 10.1371/journal.pone.0195469

PMCID:: PMC5895023

Abstract Article PDF–23M

Select item 538426210.

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca²⁺ entry

Benjamin Chun-Kit Tong, Claire Shuk-Kwan Lee, Wing-Hei Cheng, Kwok-On Lai, J. Kevin Foskett, King-Ho Cheung

Sci Signal. Author manuscript; available in PMC 2017 Sep 6.

Published in final edited form as: Sci Signal. 2016 Sep 6; 9(444): ra89. Published online 2016 Sep 6. doi: 10.1126/scisignal.aaf1371

PMCID:: PMC5384262

Abstract Article PDF–1.6M

Select item 514361711.

The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress

Qi Wu, Xiaoyang Ye, Yi Xiong, Haili Zhu, Jianting Miao, Wei Zhang, Jun Wan

Front Mol Neurosci. 2016; 9: 140. Published online 2016 Dec 8. doi: 10.3389/fnmol.2016.00140

PMCID:: PMC5143617

Abstract Article PDF–4.0M

Select item 509534712.

A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis

Yating Li, Tao Zhang, Yuncai Zhou, Yi Sun, Yue Cao, Xiaoai Chang, Yunxia Zhu, Xiao Han

Sci Rep. 2016; 6: 36136. Published online 2016 Nov 2. doi: 10.1038/srep36136

PMCID:: PMC5095347

Abstract Article PDF–2.1M

Select item 499867413.

The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal

Marianna E. Jung, Daniel B. Metzger, Hriday K. Das

J Pharmacol Exp Ther. 2016 Sep; 358(3): 516–526. Published online 2016 Sep. doi: 10.1124/jpet.116.233361

PMCID:: PMC4998674

Abstract Article PDF–1.0M

Select item 492372714.

Dysregulation of Amyloid-β Protein Precursor, β-Secretase, Presenilin 1 and 2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global Brain Ischemia

Janusz Kocki, Marzena Ułamek-Kozioł, Anna Bogucka-Kocka, Sławomir Januszewski, Mirosław Jabłoński, Paulina Gil-Kulik, Judyta Brzozowska, Alicja Petniak, Wanda Furmaga-Jabłońska, Jacek Bogucki, Stanisław J. Czuczwar, Ryszard Pluta

J Alzheimers Dis. 2015; 47(4): 1047–1056. Published online 2015 Aug 11. doi: 10.3233/JAD-150299

PMCID:: PMC4923727

Abstract Article PDF–423K

Select item 456830615.

An atomic structure of human γ-secretase

Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H.W. Scheres, Yigong Shi

Nature. Author manuscript; available in PMC 2016 Mar 10.

Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 212–217. Published online 2015 Aug 17. doi: 10.1038/nature14892

PMCID:: PMC4568306

Abstract Article PDF–6.7M

Select item 444759816.

Fyn Inhibition Rescues Established Memory and Synapse Loss in Alzheimer Mice

Adam C. Kaufman, Santiago V. Salazar, Laura T. Haas, Jinhee Yang, Mikhail A. Kostylev, Amanda T. Jeng, Sophie A. Robinson, Erik C. Gunther, Christopher H. van Dyck, Haakon B. Nygaard, Stephen M. Strittmatter

Ann Neurol. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Ann Neurol. 2015 Jun; 77(6): 953–971. Published online 2015 Mar 21. doi: 10.1002/ana.24394

PMCID:: PMC4447598

Abstract Article PDF–2.2M

Select item 416240817.

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

V Rocher-Ros, S Marco, J-H Mao, S Gines, D Metzger, P Chambon, A Balmain, CA Saura

Oncogene. Author manuscript; available in PMC 2014 Sep 12.

Published in final edited form as: Oncogene. 2010 May 20; 29(20): 2950–2961. Published online 2010 Mar 8. doi: 10.1038/onc.2010.57

PMCID:: PMC4162408

Abstract Article PDF–2.7M

Select item 407421518.

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

Sven Lang, Julia Benedix, Sorin V. Fedeles, Stefan Schorr, Claudia Schirra, Nico Schäuble, Carolin Jalal, Markus Greiner, Sarah Haßdenteufel, Jörg Tatzelt, Birgit Kreutzer, Ludwig Edelmann, Elmar Krause, Jens Rettig, Stefan Somlo, Richard Zimmermann, Johanna Dudek

J Cell Sci. 2012 Apr 15; 125(8): 1958–1969. doi: 10.1242/jcs.096727