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Select item 113352661.

Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia

Xiao-Hong Wei, Ling-Yun Liao, Yang-Xue Yin, Qin Xu, Shuang-Shuang Xie, Min Liu, Lin-Bo Gao, Hong-Qin Chen, Rong Zhou

Cell Mol Life Sci. 2024 Dec; 81(1): 336. Published online 2024 Aug 9. doi: 10.1007/s00018-024-05385-y

PMCID:: PMC11335266

Abstract Article PDF–19M

Select item 108874512.

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Endocrinology. 2024 Apr; 165(4): bqae015. Published online 2024 Feb 7. doi: 10.1210/endocr/bqae015

PMCID:: PMC10887451

Abstract Article

Select item 104636083.

Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang

J Transl Med. 2023; 21: 575. Published online 2023 Aug 26. doi: 10.1186/s12967-023-04432-9

PMCID:: PMC10463608

Abstract Article PDF–25M

Select item 103802984.

mTOR Inhibitors Modulate the Physical Properties of 3D Spheroids Derived from H9c2 Cells

Megumi Watanabe, Toshiyuki Yano, Tatsuya Sato, Araya Umetsu, Megumi Higashide, Masato Furuhashi, Hiroshi Ohguro

Int J Mol Sci. 2023 Jul; 24(14): 11459. Published online 2023 Jul 14. doi: 10.3390/ijms241411459

PMCID:: PMC10380298

Abstract Article PDF–6.7M

Select item 101882705.

Vitamin B6 Deficiency Induces Autism-Like Behaviors in Rats by Regulating mTOR-Mediated Autophagy in the Hippocampus

Lijuan Chen, Jing Li, Xinglian Liu, Zhiwei Zhao, Yan Jin, Yikun Fu, Aiqin Zhou, Chengqun Wang, Yan Zhou

Behav Neurol. 2023; 2023: 6991826. Published online 2023 May 9. doi: 10.1155/2023/6991826

PMCID:: PMC10188270

Abstract Article PDF–1.8M

Select item 99147426.

The Mechanism of Aerobic Exercise Regulating the PI3K/Akt-mTOR Signaling Pathway Intervenes in Hippocampal Neuronal Apoptosis in Vascular Dementia Rats

Lei Gao, Fushun Liu, Ruilian Liu

Int J Environ Res Public Health. 2023 Feb; 20(3): 1893. Published online 2023 Jan 19. doi: 10.3390/ijerph20031893

PMCID:: PMC9914742

Abstract Article PDF–1.0M

Select item 94674167.

LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis

Sixuan Wang, Jun Duan, Jiangquan Liao, Yan Wang, Xiang Xiao, Lin Li, Yi Liu, Huan Gu, Peng Yang, Dongliang Fu, Jinhang Du, Xianlun Li, Mingjing Shao

Aging (Albany NY) 2022 Aug 31; 14(16): 6809–6828. Published online 2022 Aug 30. doi: 10.18632/aging.204256

PMCID:: PMC9467416

Abstract Article PDF–2.1M

Select item 92189428.

Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca²⁺-CaMKII-Dependent Akt/mTOR Pathway

RUIJIE ZHANG, YU ZHU, XIAOQING DONG, BEIBEI LIU, NANA ZHANG, XIAOXUE WANG, LEI LIU, CHONG XU, SHILE HUANG, LONG CHEN

J Cell Physiol. Author manuscript; available in PMC 2022 Jun 23.

Published in final edited form as: J Cell Physiol. 2017 Aug; 232(8): 2145–2157. Published online 2017 Feb 28. doi: 10.1002/jcp.25703

PMCID:: PMC9218942

Abstract Article PDF–2.6M

Select item 89736199.

Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction

Lijie Ma, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Liu

Bioengineered. 2022; 13(2): 2217–2225. Published online 2022 Jan 14. doi: 10.1080/21655979.2021.2023996

PMCID:: PMC8973619

Abstract Article PDF–1.7M

Select item 885992510.

mTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats

Jianshu Chen, Jing Yu, Ruowen Yuan, Ningyin Li, Caie Li, Xiaofang Zhang

J Endocrinol. 2022 Mar 1; 252(3): 179–193. Published online 2021 Dec 6. doi: 10.1530/JOE-21-0284

PMCID:: PMC8859925

Abstract Article PDF–3.9M

Select item 883913311.

Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction

Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüsken

Nutrients. 2022 Feb; 14(3): 451. Published online 2022 Jan 20. doi: 10.3390/nu14030451

PMCID:: PMC8839133

Abstract Article PDF–2.2M

Select item 868316612.

Exosomes Derived from M2 Macrophages Exert a Therapeutic Effect via Inhibition of the PI3K/AKT/mTOR Pathway in Rats with Knee Osteoarthritic

Zha Xi Da-wa, Ma Jun, Liu Chao-Zheng, Yang Sen-Lin, Lu Chuan, Li De-chun, Dong Zu-Nan, Zhao Hong-tao, Wei Shu-qing, Pei Xian-wei, Liu Wenbo, Li Ke-wen

Biomed Res Int. 2021; 2021: 7218067. Published online 2021 Dec 10. doi: 10.1155/2021/7218067

PMCID:: PMC8683166

Abstract Article PDF–1.9M

Select item 856754813.

PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy

Miao Chen, Dian Jing, Rui Ye, Jianru Yi, Zhihe Zhao

Stem Cell Res Ther. 2021; 12: 566. Published online 2021 Nov 4. doi: 10.1186/s13287-021-02628-8

PMCID:: PMC8567548

Abstract Article PDF–5.7M

Select item 835037514.

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken

Mol Metab. 2021 Nov; 53: 101293. Published online 2021 Jul 13. doi: 10.1016/j.molmet.2021.101293

PMCID:: PMC8350375

Abstract Article PDF–3.1M

Select item 819716315.

TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC^S75Y Cardiomyopathy

Maengjo Kim, Linghui Lu, Alexey V. Dvornikov, Xiao Ma, Yonghe Ding, Ping Zhu, Timothy M. Olson, Xueying Lin, Xiaolei Xu

Int J Mol Sci. 2021 Jun; 22(11): 5494. Published online 2021 May 23. doi: 10.3390/ijms22115494

PMCID:: PMC8197163

Abstract Article PDF–4.6M

Select item 789552016.

Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei

Int J Mol Med. 2021 Mar; 47(3): 27. Published online 2021 Jan 27. doi: 10.3892/ijmm.2021.4860

PMCID:: PMC7895520

Abstract Article PDF–980K

Select item 749228417.

Altered expression of activator proteins that control follicle reserve after ovarian tissue cryopreservation/transplantation and primordial follicle loss prevention by rapamycin

Soner Celik, Sinan Ozkavukcu, Ciler Celik-Ozenci

J Assist Reprod Genet. 2020 Sep; 37(9): 2119–2136. Published online 2020 Jul 10. doi: 10.1007/s10815-020-01875-7

PMCID:: PMC7492284

Abstract Article PDF–42M

Select item 746956918.

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Imran A. Bhutto, Nadezda Stepicheva, Rhonda Grebe, Stacey Hose, Joseph Weiss, Tianqi Luo, Subrata Mishra, S. Amer Riazuddin, Arkasubhra Ghosh, James T. Handa, Gerard A. Lutty, J. Samuel Zigler, Jr, Debasish Sinha

Autophagy. 2020; 16(6): 1130–1142. Published online 2019 Sep 1. doi: 10.1080/15548627.2019.1660545