PMC Links for GEO Profiles (Select 26386912) - PMC

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Items: 15

Select item 96913471.

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α

Wenzhong Zheng, Kexin Wang, Yachen Wu, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen

Theranostics. 2022; 12(17): 7289–7306. Published online 2022 Oct 17. doi: 10.7150/thno.76138

PMCID:: PMC9691347

Abstract Article PDF–6.8M

Select item 60353892.

In Situ Structure of Neuronal C9ORF72 Poly-GA Aggregates Reveals Proteasome Recruitment

Qiang Guo, Carina Lehmer, Antonio Martínez-Sánchez, Till Rudack, Florian Beck, Hannelore Hartmann, Manuela Pérez-Berlanga, Frédéric Frottin, Mark S. Hipp, F. Ulrich Hartl, Dieter Edbauer, Wolfgang Baumeister, Rubén Fernández-Busnadiego

Cell. Author manuscript; available in PMC 2018 Jul 7.

Published in final edited form as: Cell. 2018 Feb 8; 172(4): 696–705.e12. Published online 2018 Feb 1. doi: 10.1016/j.cell.2017.12.030

PMCID:: PMC6035389

Abstract Article PDF–1.9M

Select item 51205413.

C9orf72 is required for proper macrophage and microglial function in mice

J. G. O’Rourke, L. Bogdanik, A. Yáñez, D. Lall, A. J. Wolf, A.K.M.G. Muhammad, R. Ho, S. Carmona, J.P. Vit, J. Zarrow, K. J. Kim, S. Bell, M. B. Harms, T. M. Miller, C. A. Dangler, D. M. Underhill, H. S. Goodridge, C. M. Lutz, R. H. Baloh

Science. Author manuscript; available in PMC 2016 Nov 23.

Published in final edited form as: Science. 2016 Mar 18; 351(6279): 1324–1329. doi: 10.1126/science.aaf1064

PMCID:: PMC5120541

Abstract Article PDF–2.2M

Select item 51197254.

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

Janet Ugolino, Yon Ju Ji, Karen Conchina, Justin Chu, Raja Sekhar Nirujogi, Akhilesh Pandey, Nathan R. Brady, Anne Hamacher-Brady, Jiou Wang

PLoS Genet. 2016 Nov; 12(11): e1006443. Published online 2016 Nov 22. doi: 10.1371/journal.pgen.1006443

PMCID:: PMC5119725

Abstract Article PDF–2.6M

Select item 51081605.

Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation

Ross Ferguson, Eleni Serafeimidou‐Pouliou, Vasanta Subramanian

J Anat. 2016 Dec; 229(6): 871–891. Published online 2016 Aug 1. doi: 10.1111/joa.12526

PMCID:: PMC5108160

Abstract Article PDF–17M

Select item 50636136.

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

Joseph Amick, Agnes Roczniak-Ferguson, Shawn M. Ferguson

Mol Biol Cell. 2016 Oct 15; 27(20): 3040–3051. doi: 10.1091/mbc.E16-01-0003

PMCID:: PMC5063613

Abstract Article PDF–3.2M

Select item 50103697.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

Mei Yang, Chen Liang, Kunchithapadam Swaminathan, Stephanie Herrlinger, Fan Lai, Ramin Shiekhattar, Jian-Fu Chen

Sci Adv. 2016 Sep; 2(9): e1601167. Published online 2016 Sep 2. doi: 10.1126/sciadv.1601167

PMCID:: PMC5010369

Abstract Article PDF–11M

Select item 49695718.

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

Christopher P Webster, Emma F Smith, Claudia S Bauer, Annekathrin Moller, Guillaume M Hautbergue, Laura Ferraiuolo, Monika A Myszczynska, Adrian Higginbottom, Matthew J Walsh, Alexander J Whitworth, Brian K Kaspar, Kathrin Meyer, Pamela J Shaw, Andrew J Grierson, Kurt J De Vos

EMBO J. 2016 Aug 1; 35(15): 1656–1676. Published online 2016 Jun 22. doi: 10.15252/embj.201694401

PMCID:: PMC4969571

Abstract Article PDF–3.2M

Select item 49105339.

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

Chantal Sellier, Maria‐Letizia Campanari, Camille Julie Corbier, Angeline Gaucherot, Isabelle Kolb‐Cheynel, Mustapha Oulad‐Abdelghani, Frank Ruffenach, Adeline Page, Sorana Ciura, Edor Kabashi, Nicolas Charlet‐Berguerand

EMBO J. 2016 Jun 15; 35(12): 1276–1297. Published online 2016 Apr 21. doi: 10.15252/embj.201593350

PMCID:: PMC4910533

Abstract Article PDF–1.5M

Select item 487081210.

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Peter M. Sullivan, Xiaolai Zhou, Adam M. Robins, Daniel H. Paushter, Dongsung Kim, Marcus B. Smolka, Fenghua Hu

Acta Neuropathol Commun. 2016; 4: 51. Published online 2016 May 18. doi: 10.1186/s40478-016-0324-5

PMCID:: PMC4870812

Abstract Article PDF–5.1M

Select item 458262011.

C9ORF72 expression and cellular localization over mouse development

Rachel A K Atkinson, Carmen M. Fernandez-Martos, Julie D. Atkin, James C. Vickers, Anna E. King

Acta Neuropathol Commun. 2015; 3: 59. Published online 2015 Sep 25. doi: 10.1186/s40478-015-0238-7

Correction in:: Acta Neuropathol Commun. 2016; 4: 2.

PMCID:: PMC4582620

Abstract Article PDF–2.5M

Select item 404931012.

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Manal A. Farg, Vinod Sundaramoorthy, Jessica M. Sultana, Shu Yang, Rachel A.K. Atkinson, Vita Levina, Mark A. Halloran, Paul A. Gleeson, Ian P. Blair, Kai Y. Soo, Anna E. King, Julie D. Atkin

Hum Mol Genet. 2014 Jul 1; 23(13): 3579–3595. Published online 2014 Feb 18. doi: 10.1093/hmg/ddu068