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Select item 59980241.

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

Wang Zheng, Xiaoyong Yang, Ruikun Hu, Ruiqi Cai, Laura Hofmann, Zhifei Wang, Qiaolin Hu, Xiong Liu, David Bulkley, Yong Yu, Jingfeng Tang, Veit Flockerzi, Ying Cao, Erhu Cao, Xing-Zhen Chen

Nat Commun. 2018; 9: 2302. Published online 2018 Jun 13. doi: 10.1038/s41467-018-04586-x

Correction in:: Nat Commun. 2019; 10: 1452.

PMCID:: PMC5998024

Abstract Article PDF–2.1M

Select item 53505162.

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

Hemant B. Badgandi, Sun-hee Hwang, Issei S. Shimada, Evan Loriot, Saikat Mukhopadhyay

J Cell Biol. 2017 Mar 6; 216(3): 743–760. doi: 10.1083/jcb.201607095

PMCID:: PMC5350516

Abstract Article PDF–3.1M

Select item 52838913.

The native TRPP2-dependent channel of murine renal primary cilia

Steven J. Kleene, Nancy K. Kleene

Am J Physiol Renal Physiol. 2017 Jan 1; 312(1): F96–F108. Published online 2016 Oct 19. doi: 10.1152/ajprenal.00272.2016

PMCID:: PMC5283891

Abstract Article

Select item 49252104.

The Polycystin complex mediates WNT/Ca²⁺ signaling

Seokho Kim, Hongguang Nie, Vasyl Nesin, Uyen Tran, Patricia Outeda, Chang-Xi Bai, Jacob Keeling, Dipak Maskey, Terry Watnick, Oliver Wessely, Leonidas Tsiokas

Nat Cell Biol. Author manuscript; available in PMC 2016 Nov 23.

Published in final edited form as: Nat Cell Biol. 2016 Jul; 18(7): 752–764. Published online 2016 May 23. doi: 10.1038/ncb3363

PMCID:: PMC4925210

Abstract Article PDF–1.8M

Select item 48556015.

Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

Mahmud Arif Pavel, Caixia Lv, Courtney Ng, Lei Yang, Parul Kashyap, Clarissa Lam, Victoria Valentino, Helen Y. Fung, Thomas Campbell, Simon Geir Møller, David Zenisek, Nathalia G. Holtzman, Yong Yu

Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17): E2363–E2372. Published online 2016 Apr 11. doi: 10.1073/pnas.1517066113

PMCID:: PMC4855601

Abstract Article PDF–1.5M

Select item 45830516.

The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function

María del Rocío Cantero, Irina F. Velázquez, Andrew J. Streets, Albert C. M. Ong, Horacio F. Cantiello

J Biol Chem. 2015 Sep 25; 290(39): 23888–23896. Published online 2015 Aug 12. doi: 10.1074/jbc.M115.661082

PMCID:: PMC4583051

Abstract Article PDF–901K

Select item 42440007.

A high-resolution structure of the EF-hand domain of human polycystin-2

Mark D Allen, Seema Qamar, Murali K Vadivelu, Richard N Sandford, Mark Bycroft

Protein Sci. 2014 Sep; 23(9): 1301–1308. Published online 2014 Jul 2. doi: 10.1002/pro.2513

PMCID:: PMC4244000

Abstract Article PDF–664K

Select item 42372838.

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Hyunho Kim, Hangxue Xu, Qin Yao, Weizhe Li, Qiong Huang, Patricia Outeda, Valeriu Cebotaru, Marco Chiaravalli, Alessandra Boletta, Klaus Piontek, Gregory G. Germino, Edward J. Weinman, Terry Watnick, Feng Qian

Nat Commun. 2014 Nov 18; 5: 5482. Published online 2014 Nov 18. doi: 10.1038/ncomms6482

PMCID:: PMC4237283

Abstract Article PDF–3.4M

Select item 42003259.

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel

Juan Du, Xin Ma, Bing Shen, Yu Huang, Lutz Birnbaumer, Xiaoqiang Yao

FASEB J. 2014 Nov; 28(11): 4677–4685. doi: 10.1096/fj.14-251652

PMCID:: PMC4200325

Abstract Article

Select item 367086810.

Müller Cell Reactivity in Response to Photoreceptor Degeneration in Rats with Defective Polycystin-2

Stefanie Vogler, Thomas Pannicke, Margrit Hollborn, Antje Grosche, Stephanie Busch, Sigrid Hoffmann, Peter Wiedemann, Andreas Reichenbach, Hans-Peter Hammes, Andreas Bringmann

PLoS One. 2013; 8(6): e61631. Published online 2013 Jun 3. doi: 10.1371/journal.pone.0061631

PMCID:: PMC3670868

Abstract Article PDF–1.6M

Select item 357743111.

Intracellular calcium release modulates polycystin-2 trafficking

Ayako Miyakawa, Cristián Ibarra, Seth Malmersjö, Anita Aperia, Peter Wiklund, Per Uhlén

BMC Nephrol. 2013; 14: 34. Published online 2013 Feb 11. doi: 10.1186/1471-2369-14-34

PMCID:: PMC3577431

Abstract Article PDF–879K

Select item 354707512.

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

Sorin V Fedeles, Xin Tian, Anna-Rachel Gallagher, Michihiro Mitobe, Saori Nishio, Seung Hun Lee, Yiqiang Cai, Lin Geng, Craig M Crews, Stefan Somlo

Nat Genet. Author manuscript; available in PMC 2013 Jan 16.

Published in final edited form as: Nat Genet. 2011 Jun 19; 43(7): 639–647. Published online 2011 Jun 19. doi: 10.1038/ng.860

PMCID:: PMC3547075

Abstract Article PDF–2.9M

Select item 350241713.

Clinical utility of PKD2 mutation testing in a polycystic kidney disease cohort attending a specialist nephrology out-patient clinic

Caroline Robinson, Thomas F Hiemstra, Deborah Spencer, Sarah Waller, Laura Daboo, Fiona E Karet Frankl, Richard N Sandford

BMC Nephrol. 2012; 13: 79. Published online 2012 Aug 3. doi: 10.1186/1471-2369-13-79

PMCID:: PMC3502417

Abstract Article PDF–645K

Select item 335986914.

A Tumor Necrosis Factor-Alpha-Mediated Pathway Promoting Autosomal Dominant Polycystic Kidney Disease

Xiaogang Li, Brenda S. Magenheimer, Sheng Xia, Teri Johnson, Darren P. Wallace, James P. Calvet, Rong Li

Nat Med. Author manuscript; available in PMC 2012 May 24.

Published in final edited form as: Nat Med. 2008 Aug; 14(8): 863–868. Published online 2008 Jun 15. doi: 10.1038/nm1783

PMCID:: PMC3359869

Abstract Article PDF–2.4M

Select item 319876515.

The Centrosomal Protein Pericentrin Identified at the Basal Body Complex of the Connecting Cilium in Mouse Photoreceptors

Johanna Mühlhans, Johann Helmut Brandstätter, Andreas Gießl

PLoS One. 2011; 6(10): e26496. Published online 2011 Oct 21. doi: 10.1371/journal.pone.0026496

PMCID:: PMC3198765

Abstract Article PDF–1.4M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311638817.

Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain

Frederico M. Ferreira, Leandro C. Oliveira, Gregory G. Germino, José N. Onuchic, Luiz F. Onuchic

Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24): 9833–9838. Published online 2011 May 27. doi: 10.1073/pnas.1106766108

PMCID:: PMC3116388

Abstract Article PDF–1.3M

Select item 308502518.

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

Wissam A. AbouAlaiwi, Maki Takahashi, Blair R. Mell, Thomas J. Jones, Shobha Ratnam, Robert J. Kolb, Surya M. Nauli

Circ Res. Author manuscript; available in PMC 2011 Apr 30.

Published in final edited form as: Circ Res. 2009 Apr 10; 104(7): 860–869. Published online 2009 Mar 5. doi: 10.1161/CIRCRESAHA.108.192765

PMCID:: PMC3085025

Abstract Article PDF–2.3M

Select item 304286919.

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

Sarah Field, Kerry-Lyn Riley, Daniel T. Grimes, Helen Hilton, Michelle Simon, Nicola Powles-Glover, Pam Siggers, Debora Bogani, Andy Greenfield, Dominic P. Norris

Development. 2011 Mar 15; 138(6): 1131–1142. doi: 10.1242/dev.058149

PMCID:: PMC3042869

Abstract Article

Select item 294090820.

Pkd1 and Pkd2 Are Required for Normal Placental Development

Miguel A. Garcia-Gonzalez, Patricia Outeda, Qin Zhou, Fang Zhou, Luis F. Menezes, Feng Qian, David L. Huso, Gregory G. Germino, Klaus B. Piontek, Terry Watnick

PLoS One. 2010; 5(9): e12821. Published online 2010 Sep 16. doi: 10.1371/journal.pone.0012821