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Select item 109415251.

FXR‐mediated epigenetic regulation of GLP‐1R expression contributes to enhanced incretin effect in diabetes after RYGB

Xiangchen Kong, Linxian Feng, Dan Yan, Bingfeng Li, Yanhui Yang, Xiaosong Ma

J Cell Mol Med. 2024 Mar; 28(6): e16339. Published online 2021 Feb 21. doi: 10.1111/jcmm.16339

PMCID:: PMC10941525

Abstract Article PDF–3.1M

Select item 107554882.

Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling

Dan-Qin Sun, Fuqiang Yuan, Meng-Zhu Fu, Meng-Yang Zhong, Shi-Liang Zhang, Yan Lu, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng, Wei-Jie Yuan

Mol Metab. 2024 Jan; 79: 101841. Published online 2023 Nov 28. doi: 10.1016/j.molmet.2023.101841

PMCID:: PMC10755488

Abstract Article PDF–5.1M

Select item 75892103.

The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure

Anna Maria Czarnecka, Krzysztof Milewski, Jan Albrecht, Magdalena Zielińska

Int J Mol Sci. 2020 Oct; 21(20): 7750. Published online 2020 Oct 20. doi: 10.3390/ijms21207750

PMCID:: PMC7589210

Abstract Article PDF–2.6M

Select item 72882134.

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

Samuel A. J. Trammell, Jens S. Svenningsen, Jens J. Holst, Matthew P. Gillum, Rune E. Kuhre

Molecules. 2020 May; 25(10): 2371. Published online 2020 May 20. doi: 10.3390/molecules25102371

PMCID:: PMC7288213

Abstract Article PDF–880K

Select item 62893385.

18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway

Shou-yan Wu, Shi-chao Cui, Le Wang, Yi-ting Zhang, Xiao-xia Yan, Heng-lei Lu, Guo-zhen Xing, Jin Ren, Li-kun Gong

Acta Pharmacol Sin. 2018 Dec; 39(12): 1865–1873. Published online 2018 Jul 30. doi: 10.1038/s41401-018-0110-y

PMCID:: PMC6289338

Abstract Article PDF–4.9M

Select item 62207886.

In vitro efficacy of pro‐ and anticoagulant strategies in compensated and acutely ill patients with cirrhosis

Ton Lisman, Simone Kleiss, Vishal C. Patel, Caleb Fisher, Jelle Adelmeijer, Sarah Bos, Arjuna Singanayagam, Sidsel H. Stoy, Debbie L. Shawcross, William Bernal

Liver Int. 2018 Nov; 38(11): 1988–1996. Published online 2018 May 30. doi: 10.1111/liv.13882

PMCID:: PMC6220788

Abstract Article PDF–556K

Select item 60529327.

Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis

Ying-Bin Hu, Xin-Yu Liu, Wei Zhan

Drug Des Devel Ther. 2018; 12: 2213–2221. Published online 2018 Jul 16. doi: 10.2147/DDDT.S170518

PMCID:: PMC6052932

Abstract Article PDF–2.0M

Select item 60300548.

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper

Nat Commun. 2018; 9: 2590. Published online 2018 Jul 3. doi: 10.1038/s41467-018-04697-5

PMCID:: PMC6030054

Abstract Article PDF–3.3M

Select item 58116219.

Effects of corilagin on alleviating cholestasis via farnesoid X receptor‐associated pathways in vitro and in vivo

Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao

Br J Pharmacol. 2018 Mar; 175(5): 810–829. Published online 2018 Jan 25. doi: 10.1111/bph.14126

PMCID:: PMC5811621

Abstract Article PDF–2.4M

Select item 561333110.

The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance

Xinfeng Yan, Peicheng Li, Zhaosheng Tang, Bo Feng

BMC Endocr Disord. 2017; 17: 60. Published online 2017 Sep 25. doi: 10.1186/s12902-017-0211-5

PMCID:: PMC5613331

Abstract Article PDF–1.1M

Select item 556641711.

Jingzhuo Tian, Jingjing Zhu, Yan Yi, Chunying Li, Yushi Zhang, Yong Zhao, Chen Pan, Shixie Xiang, Xiaolong Li, Guiqin Li, John W Newman, Xiaoyi Feng, Jing Liu, Jiayin Han, Lianmei Wang, Yue Gao, Michael R. La Frano, Aihua Liang

Sci Rep. 2017; 7: 8938. Published online 2017 Aug 21. doi: 10.1038/s41598-017-09131-2

PMCID:: PMC5566417

Abstract Article PDF–2.8M

Select item 539452512.

Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

Michał Kukla, Marek Waluga, Michał Żorniak, Agnieszka Berdowska, Piotr Wosiewicz, Tomasz Sawczyn, Rafał J Bułdak, Marek Ochman, Katarzyna Ziora, Tadeusz Krzemiński, Marek Hartleb

World J Gastroenterol. 2017 Apr 14; 23(14): 2613–2624. Published online 2017 Apr 14. doi: 10.3748/wjg.v23.i14.2613

PMCID:: PMC5394525

Abstract Article PDF–1.0M

Select item 538449313.

Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth

Xiang Hu, Qiao Zhang, Juan Zheng, Wen Kong, Hao-Hao Zhang, Tian-Shu Zeng, Jiao-Yue Zhang, Jie Min, Chaodong Wu, Lu-Lu Chen

Exp Biol Med (Maywood) 2017 Feb; 242(3): 297–304. Published online 2016 Jul 24. doi: 10.1177/1535370216641788

PMCID:: PMC5384493

Abstract Article PDF–362K

Select item 506911114.

Role of AMP-activated Protein Kinase α1 in 17α-Ethinylestradiol-induced Cholestasis in Rats

Xiaojiaoyang Li, Runping Liu, Lan Luo, Linxi Yu, Xin Chen, Lixin Sun, Tao Wang, Phillip B. Hylemon, Huiping Zhou, Zhenzhou Jiang, Luyong Zhang

Arch Toxicol. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: Arch Toxicol. 2017 Jan; 91(1): 481–494. Published online 2016 Apr 18. doi: 10.1007/s00204-016-1697-8

PMCID:: PMC5069111

Abstract Article PDF–2.2M

Select item 475963015.

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

Natalia Gomez-Ospina, Carol J. Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L. Shneider, Jennifer L. Picarsic, Theodora A. Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A. S. Knisely, Milton J. Finegold, Donna M. Muzny, Eric Boerwinkle, James R. Lupski, Sharon E. Plon, Richard A. Gibbs, Christine M. Eng, Yaping Yang, Gabriel C. Washington, Matthew H. Porteus, William E. Berquist, Neeraja Kambham, Ravinder J. Singh, Fan Xia, Gregory M. Enns, David D. Moore

Nat Commun. 2016; 7: 10713. Published online 2016 Feb 18. doi: 10.1038/ncomms10713

PMCID:: PMC4759630

Abstract Article PDF–1.1M

Select item 403920116.

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

Guodong Li, Bo Kong, Yan Zhu, Le Zhan, Jessica A. Williams, Ossama Tawfik, Karen M. Kassel, James P. Luyendyk, Li Wang, Grace L. Guo

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2014 Oct 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2013 Oct 15; 272(2): 299–305. Published online 2013 Jun 26. doi: 10.1016/j.taap.2013.06.016

PMCID:: PMC4039201

Abstract Article PDF–1.4M

Select item 397642117.

Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes

Kai Cai, Marion B. Sewer

Biochem J. Author manuscript; available in PMC 2014 Apr 4.

Published in final edited form as: Biochem J. 2013 Sep 1; 454(2): 267–274. doi: 10.1042/BJ20130609

PMCID:: PMC3976421

Abstract Article PDF–1.9M

Select item 378148418.

Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents

Andrea Mencarelli, Barbara Renga, Claudio D’Amore, Chiara Santorelli, Luigina Graziosi, Angela Bruno, Maria Chiara Monti, Eleonora Distrutti, Sabrina Cipriani, Annibale Donini, Stefano Fiorucci

Diabetes. 2013 Oct; 62(10): 3384–3393. Published online 2013 Sep 17. doi: 10.2337/db13-0299

PMCID:: PMC3781484

Abstract Article PDF–1.1M

Select item 365911419.

Ageing Fxr Deficient Mice Develop Increased Energy Expenditure, Improved Glucose Control and Liver Damage Resembling NASH

Mikael Bjursell, Marianne Wedin, Therése Admyre, Majlis Hermansson, Gerhard Böttcher, Melker Göransson, Daniel Lindén, Krister Bamberg, Jan Oscarsson, Mohammad Bohlooly-Y

PLoS One. 2013; 8(5): e64721. Published online 2013 May 20. doi: 10.1371/journal.pone.0064721

PMCID:: PMC3659114

Abstract Article PDF–2.9M

Select item 360879720.

Bile Salt Export Pump is Dysregulated with Altered Farnesoid X Receptor Isoform Expression in Patients with Hepatocellular Carcinoma

Yuan Chen, Xiulong Song, Leila Valanejad, Alexander Vasilenko, Vijay More, Xi Qiu, Weikang Chen, Yurong Lai, Angela Slitt, Matthew Stoner, Bingfang Yan, Ruitang Deng

Hepatology. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Hepatology. 2013 Apr; 57(4): 1530–1541. Published online 2013 Feb 15. doi: 10.1002/hep.26187

PMCID:: PMC3608797

Abstract Article PDF–2.8M

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