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Select item 66082591.

Regulation of the VHL/HIF-1 Pathway by DJ-1

Mohammad Parsanejad, Yi Zhang, Dianbo Qu, Isabella Irrcher, Maxime W.C. Rousseaux, Hossein Aleyasin, Fatemeh Kamkar, Steve Callaghan, Ruth S. Slack, Tak W. Mak, Stephen Lee, Daniel Figeys, David S. Park

J Neurosci. 2014 Jun 4; 34(23): 8043–8050. doi: 10.1523/JNEUROSCI.1244-13.2014

PMCID:: PMC6608259

Abstract Article PDF–1.2M

Select item 60241792.

High Frequency of Ovarian Cyst Development in Vhl^2B/+;Snf5^+/− Mice

Yasumichi Kuwahara, Leslie M. Kennedy, Anthony N. Karnezis, E. Lorena Mora-Blanco, Arlin B. Rogers, Christopher D. Fletcher, David G. Huntsman, Charles W.M. Roberts, W. Kimryn Rathmell, Bernard E. Weissman

Am J Pathol. 2018 Jul; 188(7): 1510–1516. doi: 10.1016/j.ajpath.2018.03.010

PMCID:: PMC6024179

Abstract Article

Select item 59205933.

Cloning of the Rat Homologue of the von Hippel‐Lindau Tumor Suppressor Gene and Its Non‐somatic Mutation in Rat Renal Cell Carcinomas

Yasushi Kikuchi, Etsuko Kobayashi, Masae Nishizawa, Shuji Hamazaki, Shigeru Okada, Okio Hino

Jpn J Cancer Res. 1995 Oct; 86(10): 905–909. doi: 10.1111/j.1349-7006.1995.tb02999.x

PMCID:: PMC5920593

Summary PDF–282K

Select item 58556884.

BC-Box Motif-Mediated Neuronal Differentiation of Somatic Stem Cells

Hiroshi Kanno, Yuqun Xu, Taykua Miyakawa, Atsuhiko Kubo, Tetsuhiro Higashida, Nahoko Baily Kobayashi, Tetsuhiko Yoshida, Masaru Tanokura

Int J Mol Sci. 2018 Feb; 19(2): 466. Published online 2018 Feb 5. doi: 10.3390/ijms19020466

PMCID:: PMC5855688

Abstract Article PDF–2.4M

Select item 48058565.

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Inmaculada Segura, Christian Lange, Ellen Knevels, Anastasiya Moskalyuk, Rocco Pulizzi, Guy Eelen, Thibault Chaze, Cicerone Tudor, Cyril Boulegue, Matthew Holt, Dirk Daelemans, Mariette Matondo, Bart Ghesquière, Michele Giugliano, Carmen Ruiz de Almodovar, Mieke Dewerchin, Peter Carmeliet

Cell Rep. 2016 Mar 22; 14(11): 2653–2667. Published online 2016 Mar 10. doi: 10.1016/j.celrep.2016.02.047

PMCID:: PMC4805856

Abstract Article

Select item 43618766.

Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes

Xupin Jiang, Dongxia Zhang, Hengshu Zhang, Yuesheng Huang, Miao Teng

Sci Rep. 2015; 5: 9193. Published online 2015 Mar 17. doi: 10.1038/srep09193

Correction in:: Sci Rep. 2015; 5: 11307.

PMCID:: PMC4361876

Abstract Article PDF–5.9M

Select item 33674447.

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

Clemens A. K. Lange, Ulrich F. O. Luhmann, Freya M. Mowat, Anastasios Georgiadis, Emma L. West, Sabu Abrahams, Haroon Sayed, Michael B. Powner, Marcus Fruttiger, Alexander J. Smith, Jane C. Sowden, Patrick H. Maxwell, Robin R. Ali, James W. B. Bainbridge

Development. 2012 Jul 1; 139(13): 2340–2350. doi: 10.1242/dev.070813

PMCID:: PMC3367444

Abstract Article

Select item 33236438.

Microtubular Stability Affects pVHL-Mediated Regulation of HIF-1alpha via the p38/MAPK Pathway in Hypoxic Cardiomyocytes

Miao Teng, Xu-pin Jiang, Qiong Zhang, Jia-ping Zhang, Dong-xia Zhang, Guang-ping Liang, Yue-sheng Huang

PLoS One. 2012; 7(4): e35017. Published online 2012 Apr 10. doi: 10.1371/journal.pone.0035017

PMCID:: PMC3323643

Abstract Article PDF–543K

Select item 31780599.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 217420010.

Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

Elisabeth L. Pagé, Denise A. Chan, Amato J. Giaccia, Mark Levine, Darren E. Richard

Mol Biol Cell. 2008 Jan; 19(1): 86–94. doi: 10.1091/mbc.E07-06-0612

PMCID:: PMC2174200

Abstract Article PDF–1.0M

Select item 217133811.

Regulation of ubiquitin ligase dynamics by the nucleolus

Karim Mekhail, Mireille Khacho, Amanda Carrigan, Robert R.J. Hache, Lakshman Gunaratnam, Stephen Lee

J Cell Biol. 2005 Aug 29; 170(5): 733–744. doi: 10.1083/jcb.200506030

PMCID:: PMC2171338

Abstract Article PDF–5.7M

Select item 212873212.

SUMO-specific Protease 1 is Essential for Stabilization of Hypoxia-inducible factor-1a During Hypoxia

Jinke Cheng, Xunlei Kang, Sui Zhang, Edward T.H. Yeh

Cell. Author manuscript; available in PMC 2008 Nov 2.

Published in final edited form as: Cell. 2007 Nov 2; 131(3): 584–595. doi: 10.1016/j.cell.2007.08.045

PMCID:: PMC2128732

Abstract Article PDF–3.8M

Select item 143032713.

pVHL Function Is Essential for Endothelial Extracellular Matrix Deposition

Nan Tang, Fiona Mack, Volker H. Haase, M. Celeste Simon, Randall S. Johnson

Mol Cell Biol. 2006 Apr; 26(7): 2519–2530. doi: 10.1128/MCB.26.7.2519-2530.2006

PMCID:: PMC1430327

Abstract Article PDF–1.6M

Select item 119124014.

Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors.

S A Curley, S T Lott, J W Luca, M L Frazier, A M Killary

Ann Surg. 1998 Feb; 227(2): 229–235. doi: 10.1097/00000658-199802000-00012

PMCID:: PMC1191240

Summary Page Browse PDF–1.2M

Select item 53591615.

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Takumi Kamura, Katsumi Maenaka, Shuhei Kotoshiba, Masaki Matsumoto, Daisuke Kohda, Ronald C. Conaway, Joan Weliky Conaway, Keiichi I. Nakayama

Genes Dev. 2004 Dec 15; 18(24): 3055–3065. doi: 10.1101/gad.1252404

PMCID:: PMC535916

Abstract Article PDF–465K

Select item 51790516.

Vhlh Gene Deletion Induces Hif-1-Mediated Cell Death in Thymocytes

Mangatt P. Biju, Aaron K. Neumann, Steven J. Bensinger, Randall S. Johnson, Laurence A. Turka, Volker H. Haase

Mol Cell Biol. 2004 Oct; 24(20): 9038–9047. doi: 10.1128/MCB.24.20.9038-9047.2004

PMCID:: PMC517905

Abstract Article PDF–572K

Select item 38473617.

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

Qing Liu, Utta Berchner-Pfannschmidt, Ulrike Möller, Martina Brecht, Christoph Wotzlaw, Helmut Acker, Kurt Jungermann, Thomas Kietzmann

Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4302–4307. Published online 2004 Mar 9. doi: 10.1073/pnas.0400265101

PMCID:: PMC384736

Abstract Article PDF–613K

Select item 31281418.

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Patrick C. Mahon, Kiichi Hirota, Gregg L. Semenza

Genes Dev. 2001 Oct 15; 15(20): 2675–2686. doi: 10.1101/gad.924501

PMCID:: PMC312814

Abstract Article PDF–327K

Select item 16222419.

Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α

Sang-ki Park, Agnes M. Dadak, Volker H. Haase, Lucrezia Fontana, Amato J. Giaccia, Randall S. Johnson

Mol Cell Biol. 2003 Jul; 23(14): 4959–4971. doi: 10.1128/MCB.23.14.4959-4971.2003

PMCID:: PMC162224

Abstract Article PDF–570K

Select item 15140520.

von Hippel–Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

Anna V. Kuznetsova, Jaroslaw Meller, Phillip O. Schnell, James A. Nash, Monika L. Ignacak, Yolanda Sanchez, Joan W. Conaway, Ronald C. Conaway, Maria F. Czyzyk-Krzeska

Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5): 2706–2711. Published online 2003 Feb 25. doi: 10.1073/pnas.0436037100