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Select item 96992831.

WNK kinases sense molecular crowding and rescue cell volume via phase separation

Cary R. Boyd-Shiwarski, Daniel J. Shiwarski, Shawn E. Griffiths, Rebecca T. Beacham, Logan Norrell, Daryl E. Morrison, Jun Wang, Jacob Mann, William Tennant, Eric N. Anderson, Jonathan Franks, Michael Calderon, Kelly A. Connolly, Muhammad Umar Cheema, Claire J. Weaver, Lubika J. Nkashama, Claire C. Weckerly, Katherine E. Querry, Udai Bhan Pandey, Christopher J. Donnelly, Dandan Sun, Aylin R. Rodan, Arohan R. Subramanya

Cell. Author manuscript; available in PMC 2023 Nov 23.

Published in final edited form as: Cell. 2022 Nov 23; 185(24): 4488–4506.e20. Published online 2022 Oct 31. doi: 10.1016/j.cell.2022.09.042

PMCID:: PMC9699283

Abstract Article PDF–3.7M

Select item 86847252.

Osmosensing by WNK Kinases

Radha Akella, John M. Humphreys, Kamil Sekulski, Haixia He, Mateusz Durbacz, Srinivas Chakravarthy, Joanna Liwocha, Zuhair J. Mohammed, Chad A. Brautigam, Elizabeth J. Goldsmith

Mol Biol Cell. 2021 Aug 19; 32(18): 1614–1623. doi: 10.1091/mbc.E20-01-0089

PMCID:: PMC8684725

Abstract Article PDF–3.5M

Select item 79140023.

A phosphorylated intermediate in the activation of WNK kinases

Radha Akella, Mateusz A. Drozdz, John M. Humphreys, Jenny Jiou, Mateusz Z. Durbacz, Zuhair J. Mohammed, Haixia He, Joanna Liwocha, Kamil Sekulski, Elizabeth J. Goldsmith

Biochemistry. Author manuscript; available in PMC 2021 Feb 27.

Published in final edited form as: Biochemistry. 2020 May 12; 59(18): 1747–1755. Published online 2020 Apr 24. doi: 10.1021/acs.biochem.0c00146

PMCID:: PMC7914002

Abstract Article PDF–1.4M

Select item 68896094.

Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders

Yonjung Kim, Ikhyun Jun, Dong Hoon Shin, Jihoon G. Yoon, He Piao, Jinsei Jung, Hyun Woo Park, Mary Hongying Cheng, Ivet Bahar, David C. Whitcomb, Min Goo Lee

Cell Mol Gastroenterol Hepatol. 2020; 9(1): 79–103. Published online 2019 Sep 24. doi: 10.1016/j.jcmgh.2019.09.003

PMCID:: PMC6889609

Abstract Article PDF–8.6M

Select item 55367885.

WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats

Mohammad Iqbal H Bhuiyan, Shanshan Song, Hui Yuan, Gulnaz Begum, Julia Kofler, Kristopher T Kahle, Sung-Sen Yang, Shih-Hua Lin, Seth L Alper, Arohan R Subramanya, Dandan Sun

J Cereb Blood Flow Metab. 2017 Aug; 37(8): 2780–2794. Published online 2016 Jan 1. doi: 10.1177/0271678X16675368

PMCID:: PMC5536788

Abstract Article PDF–1.5M

Select item 50806146.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl⁻ cotransporter regulation in the mammalian brain

Jinwei Zhang, Geng Gao, Gulnaz Begum, Jinhua Wang, Arjun R. Khanna, Boris E. Shmukler, Gerrit M. Daubner, Paola de los Heros, Paul Davies, Joby Varghese, Mohammad Iqbal H. Bhuiyan, Jinjing Duan, Jin Zhang, Daniel Duran, Seth L. Alper, Dandan Sun, Stephen J. Elledge, Dario R. Alessi, Kristopher T. Kahle

Sci Rep. 2016; 6: 35986. Published online 2016 Oct 26. doi: 10.1038/srep35986

PMCID:: PMC5080614

Abstract Article PDF–2.9M

Select item 49948737.

WNK1 kinase balances T cell adhesion versus migration in vivo

Robert Köchl, Flavian Thelen, Lesley Vanes, Tiago F. Brazao, Kathryn Fountain, Jian Xie, Chou-Long Huang, Ruth Lyck, Jens V. Stein, Victor L. J. Tybulewicz

Nat Immunol. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Nat Immunol. 2016 Sep; 17(9): 1075–1083. Published online 2016 Jul 11. doi: 10.1038/ni.3495

Correction in:: Nat Immunol. 2017 Jan 19; 18(2): 246.

PMCID:: PMC4994873

Abstract Article PDF–2.3M

Select item 42942878.

Identification of the WNK-SPAK/OSR1 Signaling Pathway in Rodent and Human Lenses

Irene Vorontsova, Leo Lam, Eric Delpire, Julie Lim, Paul Donaldson

Invest Ophthalmol Vis Sci. 2015 Jan; 56(1): 310–321. Published online 2015 Jan 13. doi: 10.1167/iovs.14-15911

PMCID:: PMC4294287

Abstract Article PDF–2.0M

Select item 41235279.

Chloride sensing by WNK1 kinase involves inhibition of autophosphorylation

Alexander T. Piala, Thomas M. Moon, Radha Akella, Haixia He, Melanie H. Cobb, Elizabeth J. Goldsmith

Sci Signal. Author manuscript; available in PMC 2014 Aug 6.

Published in final edited form as: Sci Signal. 2014 May 6; 7(324): ra41. Published online 2014 May 6. doi: 10.1126/scisignal.2005050

PMCID:: PMC4123527

Abstract Article PDF–1.0M

Select item 373613010.

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling

Ekatherina Serysheva, Hebist Berhane, Luca Grumolato, Kubilay Demir, Sophie Balmer, Maxime Bodak, Michael Boutros, Stuart Aaronson, Marek Mlodzik, Andreas Jenny

EMBO Rep. 2013 Aug; 14(8): 718–725. Published online 2013 Jun 25. doi: 10.1038/embor.2013.88

Correction in:: EMBO Rep. 2013 Sep; 14(9): 845.

PMCID:: PMC3736130

Abstract Article PDF–1.5M

Select item 337550811.

Taurine Inhibits K⁺-Cl⁻ Cotransporter KCC2 to Regulate Embryonic Cl⁻ Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

Koichi Inoue, Tomonori Furukawa, Tatsuro Kumada, Junko Yamada, Tianying Wang, Rieko Inoue, Atsuo Fukuda

J Biol Chem. 2012 Jun 15; 287(25): 20839–20850. Published online 2012 Apr 27. doi: 10.1074/jbc.M111.319418

PMCID:: PMC3375508

Abstract Article PDF–1.6M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 304937313.

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

Dongki Yang, Qin Li, Insuk So, Chou-Long Huang, Hideaki Ando, Akihiro Mizutani, George Seki, Katsuhiko Mikoshiba, Philip J. Thomas, Shmuel Muallem

J Clin Invest. 2011 Mar 1; 121(3): 956–965. Published online 2011 Feb 7. doi: 10.1172/JCI43475

PMCID:: PMC3049373

Abstract Article PDF–1.3M

Select item 291907814.

Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members

Charles J. Heise, Bing-e Xu, Staci L. Deaton, Seung-Kuy Cha, Chih-Jen Cheng, Svetlana Earnest, Samarpita Sengupta, Yu-Chi Juang, Steve Stippec, Yingda Xu, Yingming Zhao, Chou-Long Huang, Melanie H. Cobb

J Biol Chem. 2010 Aug 13; 285(33): 25161–25167. Published online 2010 Jun 4. doi: 10.1074/jbc.M110.103432

PMCID:: PMC2919078

Abstract Article PDF–1.6M

Select item 282034915.

WNK Kinases, Renal Ion Transport and Hypertension

Pedro San-Cristobal, Paola de los Heros, José Ponce-Coria, Erika Moreno, Gerardo Gamba

Am J Nephrol. 2008 Sep; 28(5): 860–870. Published online 2008 Jun 12. doi: 10.1159/000139639

PMCID:: PMC2820349

Abstract Article PDF–464K

Select item 273114916.

Endothelial-Specific Expression of WNK1 Kinase Is Essential for Angiogenesis and Heart Development in Mice

Jian Xie, Tao Wu, Ke Xu, Ivan K. Huang, Ondine Cleaver, Chou-Long Huang

Am J Pathol. 2009 Sep; 175(3): 1315–1327. doi: 10.2353/ajpath.2009.090094

PMCID:: PMC2731149

Abstract Article PDF–4.9M

Select item 239873517.

Mutations in the nervous system–specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II

Masoud Shekarabi, Nathalie Girard, Jean-Baptiste Rivière, Patrick Dion, Martin Houle, André Toulouse, Ronald G. Lafrenière, Freya Vercauteren, Pascale Hince, Janet Laganiere, Daniel Rochefort, Laurence Faivre, Mark Samuels, Guy A. Rouleau

J Clin Invest. 2008 Jul 1; 118(7): 2496–2505. Published online 2008 Jun 2. doi: 10.1172/JCI34088

PMCID:: PMC2398735

Abstract Article PDF–1.2M

Select item 227706918.

SLC26A9 is a Cl⁻ channel regulated by the WNK kinases

Michael R Dorwart, Nikolay Shcheynikov, Youxue Wang, Steve Stippec, Shmuel Muallem

J Physiol. 2007 Oct 1; 584(Pt 1): 333–345. Published online 2007 Aug 2. doi: 10.1113/jphysiol.2007.135855

PMCID:: PMC2277069

Abstract Article PDF–660K

Select item 147976019.

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Alberto C. Vitari, Jacob Thastrup, Fatema H. Rafiqi, Maria Deak, Nick A. Morrice, Håkan K. R. Karlsson, Dario R. Alessi

Biochem J. 2006 Jul 1; 397(Pt 1): 223–231. Prepublished online 2006 May 2. Published online 2006 Jun 14. doi: 10.1042/BJ20060220

PMCID:: PMC1479760

Abstract Article PDF–776K

Select item 136059220.

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

Ahmed Lazrak, Zhen Liu, Chou-Long Huang

Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5): 1615–1620. Published online 2006 Jan 20. doi: 10.1073/pnas.0510609103

PMCID:: PMC1360592

Abstract Article PDF–408K

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