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Items: 1 to 20 of 40

1.
Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration
Zhiqian Chen, Chen Chen, Xiao Yang, Yifan Zhou, Xiankun Cao, Chen Han, Tangjun Zhou, Jie Zhao, An Qin
Int J Biol Sci. 2024; 20(7): 2370–2387. Published online 2024 Apr 8. doi: 10.7150/ijbs.88534
PMCID:
PMC11077376
AbstractArticlePDF–12M
2.
Autophagy Induction via STING Trafficking Is a Primordial Function of the cGAS Pathway
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J. Chen
Nature. Author manuscript; available in PMC 2022 Aug 26.
Published in final edited form as: Nature. 2019 Mar; 567(7747): 262–266. Published online 2019 Mar 6. doi: 10.1038/s41586-019-1006-9
PMCID:
PMC9417302
AbstractArticlePDF–7.2M
3.
A novel rat model of vertebral inflammation–induced intervertebral disc degeneration mediated by activating cGAS/STING molecular pathway
Qihang Su, Qiuchen Cai, Yongchao Li, Hengan Ge, Yuanzhen Zhang, Yi Zhang, Jun Tan, Jie Li, Biao Cheng, Yan Zhang
J Cell Mol Med. 2021 Oct; 25(20): 9567–9585. Published online 2021 Sep 3. doi: 10.1111/jcmm.16898
PMCID:
PMC8505843
AbstractArticlePDF–5.2M
4.
cGAS/STING pathway activation contributes to delayed neurodegeneration in neonatal hypoxia-ischemia rat model: possible involvement of LINE-1
Marcin Gamdzyk, Desislava Met Doycheva, Camila Araujo, Umut Ocak, Yujie Luo, Jiping Tang, John H. Zhang
Mol Neurobiol. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Mol Neurobiol. 2020 Jun; 57(6): 2600–2619. Published online 2020 Apr 6. doi: 10.1007/s12035-020-01904-7
PMCID:
PMC7260114
AbstractArticlePDF–3.6M
5.
The role of the adaptor molecule STING during Schistosoma mansoni infection
Cláudia Souza, Rodrigo C. O. Sanches, Natan R. G. Assis, Fábio V. Marinho, Fábio S. Mambelli, Suellen B. Morais, Enrico G. T. Gimenez, Erika S. Guimarães, Tiago B. R. Castro, Sergio C. Oliveira
Sci Rep. 2020; 10: 7901. Published online 2020 May 13. doi: 10.1038/s41598-020-64788-6
PMCID:
PMC7220917
AbstractArticlePDF–1.7M
6.
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Guijun Shang, Conggang Zhang, Zhijian J. Chen, Xiao-chen Bai, Xuewu Zhang
Nature. Author manuscript; available in PMC 2019 Nov 18.
Published in final edited form as: Nature. 2019 Mar; 567(7748): 389–393. Published online 2019 Mar 6. doi: 10.1038/s41586-019-0998-5
PMCID:
PMC6859894
AbstractArticlePDF–4.8M
7.
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING
Peiyan Wang, Siji Li, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li, Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang, Fuping You
J Biol Chem. 2019 Nov 8; 294(45): 16494–16508. Published online 2019 Aug 15. doi: 10.1074/jbc.RA119.009172
PMCID:
PMC6851339
AbstractArticlePDF–3.3M
8.
The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection
Fabio V. Marinho, Sulayman Benmerzoug, Stephanie Rose, Priscila C. Campos, João T. Marques, André Báfica, Glen Barber, Bernhard Ryffel, Sergio C. Oliveira, Valerie F.J. Quesniaux
J Innate Immun. 2018 Jun; 10(3): 239–252. Published online 2018 May 23. doi: 10.1159/000488952
PMCID:
PMC6757162
AbstractArticlePDF–5.5M
9.
STING directly activates autophagy to tune the innate immune response
Dong Liu, Hao Wu, Chenguang Wang, Yanjun Li, Huabin Tian, Sami Siraj, Sheikh Arslan Sehgal, Xiaohui Wang, Jun Wang, Yingli Shang, Zhengfan Jiang, Lei Liu, Quan Chen
Cell Death Differ. 2019 Sep; 26(9): 1735–1749. Published online 2018 Dec 19. doi: 10.1038/s41418-018-0251-z
PMCID:
PMC6748081
AbstractArticlePDF–4.3M
10.
STING is required for host defense against neuropathological West Nile virus infection
Kathryn McGuckin Wuertz, Piper M. Treuting, Emily A. Hemann, Katharina Esser-Nobis, Annelise G. Snyder, Jessica B. Graham, Brian P. Daniels, Courtney Wilkins, Jessica M. Snyder, Kathleen M. Voss, Andrew Oberst, Jennifer Lund, Michael Gale, Jr.
PLoS Pathog. 2019 Aug; 15(8): e1007899. Published online 2019 Aug 15. doi: 10.1371/journal.ppat.1007899
PMCID:
PMC6695101
AbstractArticlePDF–3.5M
11.
STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
Pia-Katharina Tegtmeyer, Julia Spanier, Katharina Borst, Jennifer Becker, André Riedl, Christoph Hirche, Luca Ghita, Jennifer Skerra, Kira Baumann, Stefan Lienenklaus, Marius Doering, Zsolt Ruzsics, Ulrich Kalinke
Nat Commun. 2019; 10: 2830. Published online 2019 Jun 27. doi: 10.1038/s41467-019-10863-0
PMCID:
PMC6597531
AbstractArticlePDF–1.9M
12.
Brucella abortus cyclic dinucleotides trigger STING-dependent Unfolded Protein Response that favors bacterial replication
Erika S. Guimarães, Marco Túlio R. Gomes, Priscila C. Campos, Daniel S. Mansur, Adara A. dos Santos, Jerome Harms, Gary Splitter, Judith A. Smith, Glen N. Barber, Sergio C. Oliveira
J Immunol. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: J Immunol. 2019 May 1; 202(9): 2671–2681. Published online 2019 Mar 20. doi: 10.4049/jimmunol.1801233
PMCID:
PMC6478548
AbstractArticlePDF–1.0M
13.
Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B
Chen-Si Wu, Qian Zhao, Jun Zhang, Jing-Wen Wang, Yu Qian, Yu-Chen Fan, Kai Wang
Medicine (Baltimore) 2018 Dec; 97(52): e13904. Published online 2018 Dec 28. doi: 10.1097/MD.0000000000013904
PMCID:
PMC6314766
AbstractArticlePDF–535K
14.
The kinase IKKβ regulates a STING and NF-ĸB-dependent antiviral response pathway in Drosophila
Akira Goto, Kiyoshi Okado, Nelson Martins, Hua Cai, Vincent Barbier, Olivier Lamiable, Laurent Troxler, Estelle Santiago, Lauriane Kuhn, Donggi Paik, Neal Silverman, Andreas Holleufer, Rune Hartmann, Jiyong Liu, Tao Peng, Jules A. Hoffmann, Carine Meignin, Laurent Daeffler, Jean-Luc Imler
Immunity. Author manuscript; available in PMC 2019 Aug 21.
Published in final edited form as: Immunity. 2018 Aug 21; 49(2): 225–234.e4. Published online 2018 Aug 14. doi: 10.1016/j.immuni.2018.07.013
PMCID:
PMC6267954
AbstractArticlePDF–1.9M
15.
Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING
Hiroyasu Konno, Ivan K. Chinn, Diana Hong, Jordan S. Orange, James R. Lupski, Alejandra Mendoza, Luis A. Pedroza, Glen N. Barber
Cell Rep. Author manuscript; available in PMC 2018 Aug 15.
Published in final edited form as: Cell Rep. 2018 Apr 24; 23(4): 1112–1123. doi: 10.1016/j.celrep.2018.03.115
PMCID:
PMC6092751
AbstractArticlePDF–926K
16.
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans
Juan Sebastian Ruiz-Moreno, Lutz Hamann, Lei Jin, Leif E. Sander, Monika Puzianowska-Kuznicka, John Cambier, Martin Witzenrath, Ralf R. Schumann, Norbert Suttorp, Bastian Opitz
Infect Immun. 2018 Mar; 86(3): e00849-17. Prepublished online 2017 Dec 20. Published online 2018 Feb 20. doi: 10.1128/IAI.00849-17
PMCID:
PMC5820968
AbstractArticlePDF–1.1M
17.
STING senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum
Julien Moretti, Soumit Roy, Dominique Bozec, Jennifer Martinez, Jessica R. Chapman, Beatrix Ueberheide, Dudley W. Lamming, Zhijian J. Chen, Tiffany Horng, Garabet Yeretssian, Douglas R. Green, J. Magarian Blander
Cell. Author manuscript; available in PMC 2018 Nov 2.
Published in final edited form as: Cell. 2017 Nov 2; 171(4): 809–823.e13. Published online 2017 Oct 19. doi: 10.1016/j.cell.2017.09.034
PMCID:
PMC5811766
AbstractArticlePDF–1.2M
18.
Brucella abortus triggers a cGAS-independent STING pathway to induce host protection that involves guanylate-binding proteins and inflammasome activation
Miriam M. Costa Franco, Fernanda Marim, Erika S. Guimarães, Natan R.G. Assis, Daiane M. Cerqueira, Juliana Alves-Silva, Jerome Harms, Gary Splitter, Judith Smith, Thirumala-Devi Kanneganti, Nina M. G. P. de Queiroz, Delia Gutman, Glen N. Barber, Sergio C. Oliveira
J Immunol. Author manuscript; available in PMC 2019 Jan 15.
Published in final edited form as: J Immunol. 2018 Jan 15; 200(2): 607–622. Published online 2017 Dec 4. doi: 10.4049/jimmunol.1700725
PMCID:
PMC5760291
AbstractArticlePDF–2.3M
19.
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
Maroof Hasan, Vijay K. Gonugunta, Nicole Dobbs, Aktar Ali, Guillermo Palchik, Maria A. Calvaruso, Ralph J. DeBerardinis, Nan Yan
Proc Natl Acad Sci U S A. 2017 Jan 24; 114(4): 746–751. Published online 2017 Jan 9. doi: 10.1073/pnas.1611113114
PMCID:
PMC5278463
AbstractArticlePDF–1.3M
20.
Herpesvirus-associated lymphadenitis distorts fibroblastic reticular cell microarchitecture and attenuates CD8 T cell responses to neurotropic infection in mice lacking the STING-IFNα/β defense pathways
Derek J. Royer, Christopher D. Conrady, Daniel J.J. Carr
J Immunol. Author manuscript; available in PMC 2017 Sep 15.
Published in final edited form as: J Immunol. 2016 Sep 15; 197(6): 2338–2352. Published online 2016 Aug 10. doi: 10.4049/jimmunol.1600574
PMCID:
PMC5011016
AbstractArticlePDF–3.2M

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