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Items: 11

Select item 67426461.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 48821902.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 42633713.

A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations

Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Liang, Francisco M. Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew Mort, Peter D. Stenson, David N. Cooper, Steven M. Lipkin, Marcus B. Smolka, Haiyuan Yu

PLoS Genet. 2014 Dec; 10(12): e1004819. Published online 2014 Dec 11. doi: 10.1371/journal.pgen.1004819

PMCID:: PMC4263371

Abstract Article PDF–7.6M

Select item 36989764.

S-ADENOSYLMETHIONINE IN LIVER HEALTH, INJURY, AND CANCER

Shelly C. Lu, José M. Mato

Physiol Rev. Author manuscript; available in PMC 2013 Jul 2.

Published in final edited form as: Physiol Rev. 2012 Oct; 92(4): 1515–1542. doi: 10.1152/physrev.00047.2011

PMCID:: PMC3698976

Abstract Article PDF–1.1M

Select item 32539205.

Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate

Zigmund Luka, Svetlana Pakhomova, Lioudmila V. Loukachevitch, Marcia E. Newcomer, Conrad Wagner

Biochim Biophys Acta. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Biochim Biophys Acta. 2012 Feb; 1824(2): 286–291. Published online 2011 Oct 20. doi: 10.1016/j.bbapap.2011.10.008

PMCID:: PMC3253920

Abstract Article PDF–1.4M

Select item 31780596.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 26709677.

Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats

Kusum K. Kharbanda, Vasanthy Vigneswara, Benita L. McVicker, Anna U. Newlaczyl, Kevin Bailey, Dean Tuma, David E. Ray, Wayne G. Carter

Biochem Biophys Res Commun. 2009 Apr 17; 381(4): 523–527. doi: 10.1016/j.bbrc.2009.02.082

PMCID:: PMC2670967

Abstract Article

Select item 25764088.

Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate

Zigmund Luka, Lioudmila V. Loukachevitch, Conrad Wagner

Biochim Biophys Acta. Author manuscript; available in PMC 2009 Sep 1.

Published in final edited form as: Biochim Biophys Acta. 2008 Sep; 1784(9): 1342–1346. Published online 2008 May 2. doi: 10.1016/j.bbapap.2008.04.016

PMCID:: PMC2576408

Abstract Article PDF–862K

Select item 21440389.

Crystal structure of apo-glycine N-methyltransferase (GNMT).

R. Pattanayek, M. E. Newcomer, C. Wagner

Protein Sci. 1998 Jun; 7(6): 1326–1331. doi: 10.1002/pro.5560070608

PMCID:: PMC2144038

Summary PDF–3.0M

Select item 34527210.

Glycine N-methyltransferase is a folate binding protein of rat liver cytosol.

R J Cook, C Wagner

Proc Natl Acad Sci U S A. 1984 Jun; 81(12): 3631–3634. doi: 10.1073/pnas.81.12.3631

PMCID:: PMC345272

Summary Page Browse PDF–861K

Select item 4291611.

Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.

E J Yeo, C Wagner

Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1): 210–214. doi: 10.1073/pnas.91.1.210

PMCID:: PMC42916

Summary Page Browse PDF–2.5M

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