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Select item 88557971.

Indoxyl sulfate reduces I_to,f by activating ROS/MAPK and NF-κB signaling pathways

Jing Yang, Hongxia Li, Chi Zhang, Yafeng Zhou

JCI Insight. 2022 Feb 8; 7(3): e145475. Published online 2022 Feb 8. doi: 10.1172/jci.insight.145475

PMCID:: PMC8855797

Abstract Article PDF–15M

Select item 82030942.

IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

Seounghun Lee, Hyo-Jung Shin, Chan Noh, Song-I Kim, Young-Kwon Ko, Sun-Yeul Lee, Chaeseong Lim, Boohwi Hong, Sin-Young Yang, Dong-Woon Kim, Won-Hyung Lee, Yoon-Hee Kim

Int J Mol Sci. 2021 Jun; 22(11): 5657. Published online 2021 May 26. doi: 10.3390/ijms22115657

PMCID:: PMC8203094

Abstract Article PDF–3.3M

Select item 64653173.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand

Nat Commun. 2019; 10: 1729. Published online 2019 Apr 15. doi: 10.1038/s41467-019-09690-0

PMCID:: PMC6465317

Abstract Article PDF–2.4M

Select item 62197454.

Gain-of-function IKBKB mutation causes human combined immune deficiency

Chelisa Cardinez, Bahar Miraghazadeh, Kay Tanita, Elizabeth da Silva, Akihiro Hoshino, Satoshi Okada, Rochna Chand, Takaki Asano, Miyuki Tsumura, Kenichi Yoshida, Hidenori Ohnishi, Zenichiro Kato, Masahide Yamazaki, Yusuke Okuno, Satoru Miyano, Seiji Kojima, Seishi Ogawa, T. Daniel Andrews, Matthew A. Field, Gaetan Burgio, Tomohiro Morio, Carola G. Vinuesa, Hirokazu Kanegane, Matthew C. Cook

J Exp Med. 2018 Nov 5; 215(11): 2715–2724. doi: 10.1084/jem.20180639

PMCID:: PMC6219745

Abstract Article PDF–1.9M

Select item 55862675.

Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis

Florence L. Johnson, Nimesh S. A. Patel, Gareth S. D. Purvis, Fausto Chiazza, Jianmin Chen, Regina Sordi, Guillaume Hache, Viktoria V. Merezhko, Massimo Collino, Muhammed M. Yaqoob, Christoph Thiemermann

J Am Heart Assoc. 2017 Jul; 6(7): e005092. Published online 2017 Jul 3. doi: 10.1161/JAHA.116.005092

PMCID:: PMC5586267

Abstract Article PDF–3.2M

Select item 53700456.

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

Bo Zhang, Dan Wang, Tie-Feng Ji, Lei Shi, Jin-Lu Yu

Oncotarget. 2017 Mar 7; 8(10): 17347–17359. Published online 2016 Dec 4. doi: 10.18632/oncotarget.14468

PMCID:: PMC5370045

Abstract Article PDF–3.7M

Select item 52265737.

Jiahui An, Mengying Wu, Xiaoru Xin, Zhuojia Lin, Xiaonan Li, Qidi Zheng, Xin Gui, Tianming Li, Hu Pu, Haiyan Li, Dongdong Lu

Oncotarget. 2016 Aug 2; 7(31): 50131–50149. Published online 2016 Jun 29. doi: 10.18632/oncotarget.10321

PMCID:: PMC5226573

Abstract Article PDF–6.9M

Select item 49369388.

Targeting IκB kinase β/NF-κB signaling in human prostate cancer by a novel IκB kinase β inhibitor CmpdA

Yanting Zhang, Rena G. Lapidus, Peiyan Liu, Eun Yong Choi, Samusi Adediran, Arif Hussain, Xinghuan Wang, Xuefeng Liu, Han C. Dan

Mol Cancer Ther. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Mol Cancer Ther. 2016 Jul; 15(7): 1504–1514. Published online 2016 Apr 8. doi: 10.1158/1535-7163.MCT-15-0999

PMCID:: PMC4936938

Abstract Article PDF–2.5M

Select item 47415999.

Apigenin blocks IKKα activation and suppresses prostate cancer progression

Sanjeev Shukla, Rajnee Kanwal, Eswar Shankar, Manish Datt, Mark R. Chance, Pingfu Fu, Gregory T. MacLennan, Sanjay Gupta

Oncotarget. 2015 Oct 13; 6(31): 31216–31232. Published online 2015 Sep 5. doi: 10.18632/oncotarget.5157

PMCID:: PMC4741599

Abstract Article PDF–7.4M

Select item 459065210.

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

Wei Xie, Lei Zhang, Haifeng Jiao, Li Guan, Junmin Zha, Xiaotong Li, Mian Wu, Zhanxiang Wang, Jiahuai Han, Han You

Autophagy. 2015 Sep; 11(9): 1623–1635. Published online 2015 Jul 25. doi: 10.1080/15548627.2015.1075688

PMCID:: PMC4590652

Abstract Article PDF–1.0M

Select item 437685011.

Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

Paul R. Clark, Richard K. Kim, Jordan S. Pober, Martin S. Kluger

PLoS One. 2015; 10(3): e0120075. Published online 2015 Mar 27. doi: 10.1371/journal.pone.0120075

PMCID:: PMC4376850

Abstract Article PDF–7.3M

Select item 403523112.

Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: The role of TRPC channels

Sanjay Kumar, Saikat Chakraborty, Cindy Barbosa, Tatiana Brustovetsky, Nickolay Brustovetsky, Alexander G. Obukhov

J Cell Physiol. Author manuscript; available in PMC 2014 May 27.

Published in final edited form as: J Cell Physiol. 2012 Apr; 227(4): 1408–1419. doi: 10.1002/jcp.22855

PMCID:: PMC4035231

Abstract Article PDF–6.7M

Select item 390503313.

IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization

Huayi Lu, Qingxian Lu, Subhash Gaddipati, Ramesh Babu Kasetti, Wei Wang, Manolis Pasparakis, Henry J. Kaplan, Qiutang Li

PLoS One. 2014; 9(1): e87530. Published online 2014 Jan 28. doi: 10.1371/journal.pone.0087530

PMCID:: PMC3905033

Abstract Article PDF–2.1M

Select item 370748614.

NIBP, a Novel NIK and IKKβ-binding Protein That Enhances NF-κB Activation

Wen-Hui Hu, Julie S. Pendergast, Xian-Ming Mo, Roberta Brambilla, Valerie Bracchi-Ricard, Fang Li, Winston M. Walters, Bas Blits, Li He, Sandra M. Schaal, John R. Bethea

J Biol Chem. Author manuscript; available in PMC 2013 Jul 10.

Published in final edited form as: J Biol Chem. 2005 Aug 12; 280(32): 29233–29241. Published online 2005 Jun 10. doi: 10.1074/jbc.M501670200

PMCID:: PMC3707486

Abstract Article PDF–712K

Select item 367899915.

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein, Amanda J. Fusco, Xiangyang Zhong, Don Vu, Bärbel Schröfelbauer, Youngchang Kim, Alexander Hoffmann, Inder M. Verma, Gourisankar Ghosh, Tom Huxford

PLoS Biol. 2013 Jun; 11(6): e1001581. Published online 2013 Jun 11. doi: 10.1371/journal.pbio.1001581

PMCID:: PMC3678999

Abstract Article PDF–8.0M

Select item 366848916.

IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Zubair A. Karim, Jinchao Zhang, Meenakshi Banerjee, Michael C. Chicka, Rania Al Hawas, Tara R. Hamilton, Paul A. Roche, Sidney W. Whiteheart

Blood. 2013 May 30; 121(22): 4567–4574. Prepublished online 2013 Apr 23. doi: 10.1182/blood-2012-11-470468

Correction in:: Blood. 2013 Oct 3; 122(14): 2524.

PMCID:: PMC3668489

Abstract Article

Select item 359414117.

The NF-κB inhibitory Proteins IκBα and IκBβ Mediate Disparate Responses to Inflammation in Fetal Pulmonary Endothelial Cells

Jen-Ruey Tang, Katherine A. Michaelis, Eva Nozik-Grayck, Gregory J. Seedorf, Marlena Hartman-Filson, Steven H. Abman, Clyde J. Wright

J Immunol. Author manuscript; available in PMC 2014 Mar 15.

Published in final edited form as: J Immunol. 2013 Mar 15; 190(6): 2913–2923. Published online 2013 Feb 15. doi: 10.4049/jimmunol.1202670

PMCID:: PMC3594141

Abstract Article PDF–4.0M

Select item 353717518.

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling

Niall S. Kenneth, Sharon Mudie, Sanne Naron, Sonia Rocha

Biochem J. 2013 Jan 1; 449(Pt 1): 275–284. Prepublished online 2012 Sep 27. Published online 2012 Dec 7. doi: 10.1042/BJ20120625

PMCID:: PMC3537175

Abstract Article PDF–1.1M

Select item 352228219.

The Zinc Finger Protein ZNF268 Is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling

Wei Wang, Mingxiong Guo, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li, Zan Huang

J Biol Chem. 2012 Dec 14; 287(51): 42856–42866. Published online 2012 Oct 22. doi: 10.1074/jbc.M112.399923

PMCID:: PMC3522282

Abstract Article PDF–3.2M

Select item 349905920.

Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population

Martha L. Slattery, Esther M. John, Gabriela Torres-Mejia, Abbie Lundgreen, Jennifer S. Herrick, Kathy B. Baumgartner, Lisa M. Hines, Mariana C. Stern, Roger K. Wolff

Carcinogenesis. 2012 Aug; 33(8): 1512–1521. Published online 2012 May 4. doi: 10.1093/carcin/bgs163