PMC Links for GEO Profiles (Select 49667044) - PMC

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Items: 18

Select item 113393211.

miR-27a-3p promotes inflammatory response in infectious endophthalmitis via targeting TSC1

Yanting Chen, Shanxiang Li, Hong He

Sci Rep. 2024; 14: 19353. Published online 2024 Aug 21. doi: 10.1038/s41598-024-69964-6

PMCID:: PMC11339321

Abstract Article PDF–4.1M

Select item 66727622.

A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival

Lynsey Meikle, Delia M. Talos, Hiroaki Onda, Kristen Pollizzi, Alexander Rotenberg, Mustafa Sahin, Frances E. Jensen, David J. Kwiatkowski

J Neurosci. 2007 May 23; 27(21): 5546–5558. doi: 10.1523/JNEUROSCI.5540-06.2007

PMCID:: PMC6672762

Abstract Article PDF–865K

Select item 57308463.

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients

Mark R Woodford, Rebecca A Sager, Elijah Marris, Diana M Dunn, Adam R Blanden, Ryan L Murphy, Nicholas Rensing, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N Loh, David H Gutmann, Dimitra Bourboulia, Gennady Bratslavsky, Michael Wong, Mehdi Mollapour

EMBO J. 2017 Dec 15; 36(24): 3650–3665. Published online 2017 Nov 10. doi: 10.15252/embj.201796700

PMCID:: PMC5730846

Abstract Article PDF–1.8M

Select item 53392894.

Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia

Jae Seok Lim, Ramu Gopalappa, Se Hoon Kim, Suresh Ramakrishna, Minji Lee, Woo-il Kim, Junho Kim, Sang Min Park, Junehawk Lee, Jung-Hwa Oh, Heung Dong Kim, Chang-Hwan Park, Joon Soo Lee, Sangwoo Kim, Dong Seok Kim, Jung Min Han, Hoon-Chul Kang, Hyongbum (Henry) Kim, Jeong Ho Lee

Am J Hum Genet. 2017 Mar 2; 100(3): 454–472. Published online 2017 Feb 16. doi: 10.1016/j.ajhg.2017.01.030

PMCID:: PMC5339289

Abstract Article PDF–3.3M

Select item 50707995.

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model

Shilpa Prabhakar, Xuan Zhang, June Goto, Sangyeul Han, Charles Lai, Roderick Bronson, Miguel Sena-Esteves, Vijaya Ramesh, Anat Stemmer-Rachamimov, David J. Kwiatkowski, Xandra O. Breakefield

Neurobiol Dis. Author manuscript; available in PMC 2016 Oct 19.

Published in final edited form as: Neurobiol Dis. 2015 Oct; 82: 22–31. Published online 2015 May 24. doi: 10.1016/j.nbd.2015.04.018

PMCID:: PMC5070799

Abstract Article PDF–1.4M

Select item 47346356.

Regulation of mTORC1 by PI3K Signaling

Christian C. Dibble, Lewis C. Cantley

Trends Cell Biol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Trends Cell Biol. 2015 Sep; 25(9): 545–555. Published online 2015 Jul 6. doi: 10.1016/j.tcb.2015.06.002

PMCID:: PMC4734635

Abstract Article PDF–530K

Select item 42409207.

Neurogenin 3–Directed Cre Deletion of Tsc1 Gene Causes Pancreatic Acinar Carcinoma

Li Ding, Lingling Han, Yin Li, Jing Zhao, Ping He, Weizhen Zhang

Neoplasia. 2014 Nov; 16(11): 909–917. Published online 2014 Nov 20. doi: 10.1016/j.neo.2014.08.010

PMCID:: PMC4240920

Abstract Article PDF–1.8M

Select item 42056128.

Tsc1 promotes the differentiation of memory CD8⁺ T cells via orchestrating the transcriptional and metabolic programs

Sharad Shrestha, Kai Yang, Jun Wei, Peer W. F. Karmaus, Geoffrey Neale, Hongbo Chi

Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41): 14858–14863. Published online 2014 Sep 30. doi: 10.1073/pnas.1404264111

PMCID:: PMC4205612

Abstract Article PDF–1.5M

Select item 37441349.

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Michalis Papadakis, Gina Hadley, Maria Xilouri, Lisa C. Hoyte, Simon Nagel, M Mary McMenamin, Grigorios Tsaknakis, Suzanne M. Watt, Cynthia Wright Drakesmith, Ruoli Chen, Matthew J A Wood, Zonghang Zhao, Benedikt Kessler, Kostas Vekrellis, Alastair M. Buchan

Nat Med. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Nat Med. 2013 Mar; 19(3): 351–357. Published online 2013 Feb 24. doi: 10.1038/nm.3097

PMCID:: PMC3744134

Abstract Article PDF–3.4M

Select item 317805910.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 306978311.

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

David M. Feliciano, Tiffany Su, Jean Lopez, Jean-Claude Platel, Angélique Bordey

J Clin Invest. 2011 Apr 1; 121(4): 1596–1607. Published online 2011 Mar 14. doi: 10.1172/JCI44909

PMCID:: PMC3069783

Abstract Article PDF–8.0M

Select item 285970812.

TSC1 Sets the Rate of Ribosome Export and Protein Synthesis through Nucleophosmin Translation

Corey L. Pelletier, Leonard B. Maggi, Jr., Suzanne N. Brady, Danielle K. Scheidenhelm, David H. Gutmann, Jason D. Weber

Cancer Res. Author manuscript; available in PMC 2010 Apr 26.

Published in final edited form as: Cancer Res. 2007 Feb 15; 67(4): 1609–1617. doi: 10.1158/0008-5472.CAN-06-2875

PMCID:: PMC2859708

Abstract Article PDF–1.4M

Select item 284170013.

TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity

Mei-Chih Liang, Jian Ma, Liang Chen, Piotr Kozlowski, Wei Qin, Danan Li, Takeshi Shimamura, Roman K. Thomas, D. Neil Hayes, Matthew Meyerson, David J. Kwiatkowski, Kwok-Kin Wong

Oncogene. Author manuscript; available in PMC 2010 Sep 18.

Published in final edited form as: Oncogene. 2010 Mar 18; 29(11): 1588–1597. Published online 2009 Dec 7. doi: 10.1038/onc.2009.452

PMCID:: PMC2841700

Abstract Article PDF–759K

Select item 269185414.

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

Alessia Di Nardo, Ioannis Kramvis, Namjik Cho, Abbey Sadowski, Lynsey Meikle, David J. Kwiatkowski, Mustafa Sahin

J Neurosci. 2009 May 6; 29(18): 5926–5937. doi: 10.1523/JNEUROSCI.0778-09.2009

PMCID:: PMC2691854

Abstract Article PDF–678K

Select item 240843315.

The Tuberous Sclerosis Complex Regulates Trafficking of Glucose Transporters and Glucose Uptake

Xiuyun Jiang, Heidi Kenerson, Lauri Aicher, Robert Miyaoka, Janet Eary, John Bissler, Raymond S. Yeung

Am J Pathol. 2008 Jun; 172(6): 1748–1756. doi: 10.2353/ajpath.2008.070958

PMCID:: PMC2408433

Abstract Article PDF–1.0M

Select item 217259816.

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

Elena Goncharova, Dmitry Goncharov, Daniel Noonan, Vera P. Krymskaya

J Cell Biol. 2004 Dec 20; 167(6): 1171–1182. doi: 10.1083/jcb.200405130

PMCID:: PMC2172598

Abstract Article PDF–6.0M

Select item 206381817.

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Sheng-Li Cai, Andrew R. Tee, John D. Short, Judith M. Bergeron, Jinhee Kim, Jianjun Shen, Ruifeng Guo, Charles L. Johnson, Kaoru Kiguchi, Cheryl Lyn Walker

J Cell Biol. 2006 Apr 24; 173(2): 279–289. doi: 10.1083/jcb.200507119