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Select item 108981051.

TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway

Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai, Xiaoping Zhu

Mol Brain. 2024; 17: 12. Published online 2024 Feb 26. doi: 10.1186/s13041-024-01081-x

PMCID:: PMC10898105

Abstract Article PDF–4.3M

Select item 105771092.

Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway

Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Hao

J Neuroimmune Pharmacol. 2023; 18(3): 476–494. Published online 2023 Sep 2. doi: 10.1007/s11481-023-10081-y

PMCID:: PMC10577109

Abstract Article PDF–4.0M

Select item 99606573.

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair

Jinghui Xu, Liying Zhang, Mingyue Li, Xiaofei He, Jing Luo, Rui Wu, Zhongqiu Hong, Haiqing Zheng, Xiquan Hu

J Neuroinflammation. 2023; 20: 50. Published online 2023 Feb 25. doi: 10.1186/s12974-023-02741-w

PMCID:: PMC9960657

Abstract Article PDF–16M

Select item 76820664.

Diesel exhaust impairs TREM2 to dysregulate neuroinflammation

Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti, Michelle L. Block

J Neuroinflammation. 2020; 17: 351. Published online 2020 Nov 22. doi: 10.1186/s12974-020-02017-7

PMCID:: PMC7682066

Abstract Article PDF–3.8M

Select item 75641895.

DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke

Ludmila Belayev, Sung‐Ha Hong, Raul S. Freitas, Hemant Menghani, Shawn J. Marcell, Larissa Khoutorova, Pranab K. Mukherjee, Madigan M. Reid, Reinaldo B. Oria, Nicolas G. Bazan

CNS Neurosci Ther. 2020 Nov; 26(11): 1155–1167. Published online 2020 Aug 5. doi: 10.1111/cns.13444

PMCID:: PMC7564189

Abstract Article PDF–2.8M

Select item 70580576.

Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant

Marc D. Tambini, Luciano D’Adamio

Sci Rep. 2020; 10: 4122. Published online 2020 Mar 5. doi: 10.1038/s41598-020-60800-1

PMCID:: PMC7058057

Abstract Article PDF–4.4M

Select item 70130927.

Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis

Wurong Li, Haoxiao Chang, Wenqing Wu, Dongmei Xu, Meijuan Jiang, Junhua Gao, Yuming Huang, Yun Xu, Linlin Yin, Xinghu Zhang

Front Neurol. 2020; 11: 62. Published online 2020 Feb 5. doi: 10.3389/fneur.2020.00062

PMCID:: PMC7013092

Abstract Article PDF–756K

Select item 69424138.

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang, Jianliang Fu

J Neuroinflammation. 2020; 17: 2. Published online 2020 Jan 3. doi: 10.1186/s12974-019-1688-9

PMCID:: PMC6942413

Abstract Article PDF–3.5M

Select item 65902669.

TREM2 triggers microglial density and age‐related neuronal loss

Bettina Linnartz‐Gerlach, Liviu‐Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neumann

Glia. 2019 Mar; 67(3): 539–550. Published online 2018 Dec 11. doi: 10.1002/glia.23563

PMCID:: PMC6590266

Abstract Article PDF–6.5M

Select item 617661410.

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Faten A. Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A. Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, Li Gan

Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): 10172–10177. Published online 2018 Sep 19. doi: 10.1073/pnas.1811411115

PMCID:: PMC6176614

Abstract Article PDF–1.5M

Select item 598480411.

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth

Mol Neurodegener. 2018; 13: 29. Published online 2018 Jun 1. doi: 10.1186/s13024-018-0262-8

PMCID:: PMC5984804

Abstract Article PDF–1.6M

Select item 588909212.

TREM2 is a receptor for β-amyloid which mediates microglial function

Yingjun Zhao, Xilin Wu, Xiaoguang Li, Lu-Lin Jiang, Xun Gui, Yan Liu, Yu Sun, Bing Zhu, Juan C. Piña-Crespo, Muxian Zhang, Ningyan Zhang, Xiaochun Chen, Guojun Bu, Zhiqiang An, Timothy Y. Huang, Huaxi Xu

Neuron. Author manuscript; available in PMC 2019 Mar 7.

Published in final edited form as: Neuron. 2018 Mar 7; 97(5): 1023–1031.e7. doi: 10.1016/j.neuron.2018.01.031

PMCID:: PMC5889092

Abstract Article PDF–1.7M

Select item 566338613.

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman

Proc Natl Acad Sci U S A. 2017 Oct 24; 114(43): 11524–11529. Published online 2017 Oct 9. doi: 10.1073/pnas.1710311114

PMCID:: PMC5663386

Abstract Article PDF–1.4M

Select item 564702914.

TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs

Pei Ye, Dawei Xu, Jinhuang Xu, Guiwang Liu, Shenghui Huang, Weiqiong Zhang, Peizhong Zheng, Jianhua Li, Jianrong Huang

Mol Med Rep. 2017 Oct; 16(4): 4777–4783. Published online 2017 Aug 10. doi: 10.3892/mmr.2017.7212

PMCID:: PMC5647029

Abstract Article PDF–1.4M

Select item 562385915.

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass

EMBO Mol Med. 2017 Oct; 9(10): 1356–1365. Published online 2017 Aug 30. doi: 10.15252/emmm.201707672

PMCID:: PMC5623859

Abstract Article PDF–1.1M

Select item 562383916.

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther

EMBO Mol Med. 2017 Oct; 9(10): 1366–1378. Published online 2017 Aug 30. doi: 10.15252/emmm.201707673

PMCID:: PMC5623839

Abstract Article PDF–1.6M

Select item 557322417.

TREM2 maintains microglial metabolic fitness in Alzheimer’s disease

Tyler K. Ulland, Wilbur M Song, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna

Cell. Author manuscript; available in PMC 2018 Aug 10.

Published in final edited form as: Cell. 2017 Aug 10; 170(4): 649–663.e13. doi: 10.1016/j.cell.2017.07.023

PMCID:: PMC5573224

Abstract Article PDF–2.7M

Select item 549453218.

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass

EMBO Rep. 2017 Jul; 18(7): 1186–1198. Published online 2017 May 8. doi: 10.15252/embr.201743922

PMCID:: PMC5494532

Abstract Article PDF–4.5M

Select item 546172019.

TREM2 protects against cerebral ischemia/reperfusion injury

Rong Wu, Xiangpen Li, Pengfei Xu, Likui Huang, Jinping Cheng, Xiaolong Huang, Jingru Jiang, Long-Jun Wu, Yamei Tang

Mol Brain. 2017; 10: 20. Published online 2017 Jun 7. doi: 10.1186/s13041-017-0296-9

PMCID:: PMC5461720

Abstract Article PDF–4.1M

Select item 517332220.

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Daniel L Kober, Jennifer M Alexander-Brett, Celeste M Karch, Carlos Cruchaga, Marco Colonna, Michael J Holtzman, Thomas J Brett

eLife. 2016; 5: e20391. Published online 2016 Dec 20. doi: 10.7554/eLife.20391

PMCID:: PMC5173322

Abstract Article PDF–3.8M

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