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Select item 108052621.

miR-29c-3p Attenuates β-Amyloid-Induced Neurotoxicity in Alzheimer’s Disease Through Regulating β-Site Amyloid Precursor Protein-Cleaving Enzyme 1

Xiaoping WANG, Min LI, Yinbao HU

Physiol Res. 2023 Dec; 72(6): 833–841. Published online 2023 Dec 31. doi: 10.33549/physiolres.935084

PMCID:: PMC10805262

Abstract Article PDF–993K

Select item 87945212.

MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer’s disease by downregulation of HNRNPU stabilized BACE1

Jie Qu, Xiaowei Xiong, Gulibaha Hujie, Jun Ren, Lihui Yan, Liqun Ma

Cell Cycle. 2021; 20(21): 2309–2320. Published online 2021 Sep 29. doi: 10.1080/15384101.2021.1982507

PMCID:: PMC8794521

Abstract Article PDF–2.9M

Select item 78099003.

Nogo-66 promotes β-amyloid protein secretion via NgR/ROCK-dependent BACE1 activation

Qing-Qing Xie, Xiao Feng, Yi-Yun Huang, Nian Fang, Hua Yi, Zi-Jian Wang, Qiao-Yu Cao, Guo-Feng Lou, Jun-Ping Pan, Yang Hu, Fang-Cheng Li, Qing Zheng, Fei Xiao

Mol Med Rep. 2021 Mar; 23(3): 188. Published online 2021 Jan 5. doi: 10.3892/mmr.2021.11827

PMCID:: PMC7809900

Abstract Article PDF–5.8M

Select item 72173734.

Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson’s disease by upregulating microRNA-34b-5p and downregulating BACE1

Yanhong Li, Jian Fang, Zhanye Zhou, Qiyu Zhou, Shibin Sun, Zhikai Jin, Ziming Xi, Jianshe Wei

Cell Cycle. 2020; 19(10): 1158–1171. Published online 2020 Apr 19. doi: 10.1080/15384101.2020.1749447

Expression of Concern in:: Cell Cycle. 2022; 21(24): 2675.

PMCID:: PMC7217373

Abstract Article PDF–5.1M

Select item 67057175.

BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis

Shuting Zhang, Zhe Wang, Fang Cai, Mingming Zhang, Yili Wu, Jing Zhang, Weihong Song

J Neurosci. 2017 Jul 19; 37(29): 6915–6925. doi: 10.1523/JNEUROSCI.0340-17.2017

PMCID:: PMC6705717

Abstract Article PDF–2.5M

Select item 66744116.

Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme

Robert Spoelgen, Christine A. F. von Arnim, Anne V. Thomas, Ithan D. Peltan, Mirjam Koker, Amy Deng, Michael C. Irizarry, Olav M. Andersen, Thomas E. Willnow, Bradley T. Hyman

J Neurosci. 2006 Jan 11; 26(2): 418–428. doi: 10.1523/JNEUROSCI.3882-05.2006

PMCID:: PMC6674411

Abstract Article PDF–535K

Select item 59326407.

BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism

Anna L. Stern, Shivesh Ghura, Patrick J. Gannon, Cagla Akay-Espinoza, Jessica M. Phan, Alan C. Yee, Robert Vassar, Benjamin B. Gelman, Dennis L. Kolson, Kelly L. Jordan-Sciutto

J Neurosci. 2018 May 2; 38(18): 4288–4300. doi: 10.1523/JNEUROSCI.1280-17.2018

PMCID:: PMC5932640

Abstract Article PDF–3.2M

Select item 57683868.

MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1

Fengmao An, Guohua Gong, Yu Wang, Ming Bian, Lijun Yu, Chengxi Wei

Oncotarget. 2017 Dec 26; 8(69): 114065–114071. Published online 2017 Dec 9. doi: 10.18632/oncotarget.23119

Correction in:: Oncotarget. 2018 May 15; 9(37): 24871.

PMCID:: PMC5768386

Abstract Article PDF–2.5M

Select item 57611179.

Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease

Liang Feng, Yu-Ting Liao, Jin-Cai He, Cheng-Long Xie, Si-Yan Chen, Hui-Hui Fan, Zhi-Peng Su, Zhen Wang

BMC Neurol. 2018; 18: 4. Published online 2018 Jan 9. doi: 10.1186/s12883-017-1008-x

PMCID:: PMC5761117

Abstract Article PDF–1.3M

Select item 561173610.

BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology

E N Wilson, S Do Carmo, M F Iulita, H Hall, A Ducatenzeiler, A R Marks, S Allard, D T Jia, J Windheim, A C Cuello

Transl Psychiatry. 2017 Aug; 7(8): e1190. Published online 2017 Aug 1. doi: 10.1038/tp.2017.169

PMCID:: PMC5611736

Abstract Article PDF–783K

Select item 534504711.

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

Martin Weber, Tiffany Wu, William J. Meilandt, Sara L. Dominguez, Hilda O. Solanoy, Janice A. Maloney, Hai Ngu, Miriam Baca, Chung Kung, Lisa Lima, Timothy K. Earr, Daniel Fleck, Shannon D. Shields, William F. Forrest, Oded Foreman, Søren Warming, Ryan J. Watts, Kimberly Scearce-Levie

Sci Rep. 2017; 7: 44249. Published online 2017 Mar 10. doi: 10.1038/srep44249

PMCID:: PMC5345047

Abstract Article PDF–1.1M

Select item 530104412.

miR‐15b mediates oxaliplatin‐induced chronic neuropathic pain through BACE1 down‐regulation

Naomi Ito, Atsushi Sakai, Noriko Miyake, Motoyo Maruyama, Hirotoshi Iwasaki, Koichi Miyake, Takashi Okada, Atsuhiro Sakamoto, Hidenori Suzuki

Br J Pharmacol. 2017 Mar; 174(5): 386–395. Published online 2017 Jan 23. doi: 10.1111/bph.13698

PMCID:: PMC5301044

Abstract Article PDF–522K

Select item 506400613.

Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain

Xike Qin, Yunling Wang, Hemant K. Paudel

J Biol Chem. 2016 Oct 14; 291(42): 22276–22287. Published online 2016 Aug 30. doi: 10.1074/jbc.M116.738849

PMCID:: PMC5064006

Abstract Article PDF–2.6M

Select item 495705714.

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation

Eniola Funmilayo Aduke Yeates, Giuseppina Tesco

J Biol Chem. 2016 Jul 22; 291(30): 15753–15766. Published online 2016 Jun 14. doi: 10.1074/jbc.M116.718023

PMCID:: PMC4957057

Abstract Article PDF–1.5M

Select item 492372715.

Dysregulation of Amyloid-β Protein Precursor, β-Secretase, Presenilin 1 and 2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global Brain Ischemia

Janusz Kocki, Marzena Ułamek-Kozioł, Anna Bogucka-Kocka, Sławomir Januszewski, Mirosław Jabłoński, Paulina Gil-Kulik, Judyta Brzozowska, Alicja Petniak, Wanda Furmaga-Jabłońska, Jacek Bogucki, Stanisław J. Czuczwar, Ryszard Pluta

J Alzheimers Dis. 2015; 47(4): 1047–1056. Published online 2015 Aug 11. doi: 10.3233/JAD-150299

PMCID:: PMC4923727

Abstract Article PDF–423K

Select item 463810216.

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

Naomi Mamada, Daisuke Tanokashira, Ai Hosaka, Fuyuki Kametani, Akira Tamaoka, Wataru Araki

Mol Brain. 2015; 8: 73. Published online 2015 Nov 9. doi: 10.1186/s13041-015-0163-5

PMCID:: PMC4638102

Abstract Article PDF–1.9M

Select item 453107317.

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase

Amir Kumar Singh, Uttam Pati

Aging Cell. 2015 Aug; 14(4): 595–604. Published online 2015 Mar 13. doi: 10.1111/acel.12335

PMCID:: PMC4531073

Abstract Article PDF–1.3M

Select item 432864718.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi

EMBO Mol Med. 2015 Feb; 7(2): 175–189. Published online 2015 Jan 15. doi: 10.15252/emmm.201404438

PMCID:: PMC4328647

Abstract Article PDF–2.3M

Select item 411027519.

β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins

Wanxia He, Jinxuan Hu, Yuxing Xia, Riqiang Yan

J Biol Chem. 2014 Jul 25; 289(30): 20630–20637. Published online 2014 Jun 6. doi: 10.1074/jbc.M114.579862

PMCID:: PMC4110275

Abstract Article PDF–1.8M

Select item 385003620.

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-β Production in an Alzheimer's Disease Mouse Model

Jeremy H. Herskowitz, Yangbo Feng, Alexa L. Mattheyses, Chadwick M. Hales, Lenora A. Higginbotham, Duc M. Duong, Thomas J. Montine, Juan C. Troncoso, Madhav Thambisetty, Nicholas T. Seyfried, Allan I. Levey, James J. Lah

J Neurosci. 2013 Dec 4; 33(49): 19086–19098. doi: 10.1523/JNEUROSCI.2508-13.2013