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Select item 72904151.

Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex

Laura Solé, Daniel Sastre, Magalí Colomer-Molera, Albert Vallejo-Gracia, Sara R. Roig, Mireia Pérez-Verdaguer, Pilar Lillo, Michael M. Tamkun, Antonio Felipe

Cells. 2020 May; 9(5): 1128. Published online 2020 May 2. doi: 10.3390/cells9051128

PMCID:: PMC7290415

Abstract Article PDF–4.7M

Select item 67410042.

Distinct Roles of Kv1 and Kv3 Potassium Channels at the Calyx of Held Presynaptic Terminal

Taro Ishikawa, Yukihiro Nakamura, Naoto Saitoh, Wen-Bin Li, Shinichi Iwasaki, Tomoyuki Takahashi

J Neurosci. 2003 Nov 12; 23(32): 10445–10453. doi: 10.1523/JNEUROSCI.23-32-10445.2003

PMCID:: PMC6741004

Abstract Article PDF–390K

Select item 67252343.

Microglia Kv1.3 Channels Contribute to Their Ability to Kill Neurons

Christopher B. Fordyce, Ravi Jagasia, Xiaoping Zhu, Lyanne C. Schlichter

J Neurosci. 2005 Aug 3; 25(31): 7139–7149. doi: 10.1523/JNEUROSCI.1251-05.2005

PMCID:: PMC6725234

Abstract Article PDF–680K

Select item 65786694.

Tyrosine phosphorylation of the Kv1.3 potassium channel

TC Holmes, DA Fadool, IB Levitan

J Neurosci. 1996 Mar 1; 16(5): 1581–1590. doi: 10.1523/JNEUROSCI.16-05-01581.1996

PMCID:: PMC6578669

Abstract PDF–3.2M

Select item 63223145.

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko, Christine Beeton

Arthritis Res Ther. 2019; 21: 6. Published online 2019 Jan 7. doi: 10.1186/s13075-018-1783-9

PMCID:: PMC6322314

Abstract Article PDF–6.9M

Select item 54738076.

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan

Sci Rep. 2017; 7: 3756. Published online 2017 Jun 16. doi: 10.1038/s41598-017-03998-x

PMCID:: PMC5473807

Abstract Article PDF–2.5M

Select item 53379937.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan

Nat Commun. 2017; 8: 14644. Published online 2017 Mar 1. doi: 10.1038/ncomms14644

PMCID:: PMC5337993

Abstract Article PDF–2.6M

Select item 53012578.

Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation

Ramón Martínez-Mármol, Katarzyna Styrczewska, Mireia Pérez-Verdaguer, Albert Vallejo-Gracia, Núria Comes, Alexander Sorkin, Antonio Felipe

Sci Rep. 2017; 7: 42395. Published online 2017 Feb 10. doi: 10.1038/srep42395

PMCID:: PMC5301257

Abstract Article PDF–2.8M

Select item 51381389.

Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K⁺ current conducted by K_V1.3

Han Liu, Jianuo Liu, Enquan Xu, Guihua Tu, Minglei Guo, Shangdong Liang, Huangui Xiong

Neurobiol Dis. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: Neurobiol Dis. 2017 Jan; 97(Pt A): 1–10. Published online 2016 Nov 2. doi: 10.1016/j.nbd.2016.10.007

PMCID:: PMC5138138

Abstract Article PDF–3.6M

Select item 511719910.

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit

Laura Solé, Sara R. Roig, Albert Vallejo-Gracia, Antonio Serrano-Albarrás, Ramón Martínez-Mármol, Michael M. Tamkun, Antonio Felipe

J Cell Sci. 2016 Nov 15; 129(22): 4265–4277. doi: 10.1242/jcs.191650

PMCID:: PMC5117199

Abstract Article

Select item 413277711.

Targeting the Ion Channel Kv1.3 with Scorpion Venom Peptides Engineered for Potency, Selectivity, and Half-life

Wilson Edwards, Wai-Ping Fung-Leung, Chichi Huang, Ellen Chi, Nancy Wu, Yi Liu, Michael P. Maher, Rachelle Bonesteel, Judith Connor, Ross Fellows, Elena Garcia, Jerry Lee, Lu Lu, Karen Ngo, Brian Scott, Hong Zhou, Ronald V. Swanson, Alan D. Wickenden

J Biol Chem. 2014 Aug 15; 289(33): 22704–22714. Published online 2014 Jun 17. doi: 10.1074/jbc.M114.568642

PMCID:: PMC4132777

Abstract Article PDF–1.9M

Select item 400745212.

Blocking K_V1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

Shyny Koshy, Redwan Huq, Mark R. Tanner, Mustafa A. Atik, Paul C. Porter, Fatima S. Khan, Michael W. Pennington, Nicola A. Hanania, David B. Corry, Christine Beeton

J Biol Chem. 2014 May 2; 289(18): 12623–12632. Published online 2014 Mar 18. doi: 10.1074/jbc.M113.517037

PMCID:: PMC4007452

Abstract Article PDF–1.5M

Select item 392297413.

Effect of Methamphetamine on the Microglial Damage: Role of Potassium Channel Kv1.3

Jun Wang, Wenyi Qian, Jingli Liu, Jingjing Zhao, Pan Yu, Lei Jiang, Jing Zhou, Rong Gao, Hang Xiao

PLoS One. 2014; 9(2): e88642. Published online 2014 Feb 12. doi: 10.1371/journal.pone.0088642

PMCID:: PMC3922974

Abstract Article PDF–1.2M

Select item 382067714.

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

M. Harunur Rashid, Germano Heinzelmann, Redwan Huq, Rajeev B. Tajhya, Shih Chieh Chang, Sandeep Chhabra, Michael W. Pennington, Christine Beeton, Raymond S. Norton, Serdar Kuyucak

PLoS One. 2013; 8(11): e78712. Published online 2013 Nov 7. doi: 10.1371/journal.pone.0078712

PMCID:: PMC3820677

Abstract Article PDF–999K

Select item 358507915.

Intracellular Trafficking of the K_V1.3 Potassium Channel Is Regulated by the Prodomain of a Matrix Metalloprotease

Hai M. Nguyen, Charles A. Galea, Galina Schmunk, Brian J. Smith, Robert A. Edwards, Raymond S. Norton, K. George Chandy

J Biol Chem. 2013 Mar 1; 288(9): 6451–6464. Published online 2013 Jan 8. doi: 10.1074/jbc.M112.421495

PMCID:: PMC3585079

Abstract Article PDF–3.5M

Select item 343614716.

Selective Inhibition of CCR7⁻ Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model

Zhi Li, Wan-Hong Liu, Song Han, Bi-Wen Peng, Jun Yin, Ying-Liang Wu, Xiao-Hua He, Wen-Xin Li

J Biol Chem. 2012 Aug 24; 287(35): 29479–29494. Published online 2012 Jul 3. doi: 10.1074/jbc.M112.379594

PMCID:: PMC3436147

Abstract Article PDF–6.3M

Select item 343061717.

Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

Tongguang Wang, Myoung-Hwa Lee, Elliot Choi, Carlos A. Pardo-Villamizar, Sung Bin Lee, In Hong Yang, Peter A. Calabresi, Avindra Nath

PLoS One. 2012; 7(8): e43950. Published online 2012 Aug 29. doi: 10.1371/journal.pone.0043950

PMCID:: PMC3430617

Abstract Article PDF–1.1M

Select item 337556318.

Protein Kinase C (PKC) Activity Regulates Functional Effects of K_vβ1.3 Subunit on K_V1.5 Channels: IDENTIFICATION OF A CARDIAC K_v1.5 CHANNELOSOME

Miren David, Álvaro Macías, Cristina Moreno, Ángela Prieto, Ramón Martínez-Mármol, Rubén Vicente, Teresa González, Antonio Felipe, Michael M. Tamkun, Carmen Valenzuela

J Biol Chem. 2012 Jun 15; 287(25): 21416–21428. Published online 2012 Apr 30. doi: 10.1074/jbc.M111.328278