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Select item 45898721.

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

Deanna N. Edwards, Amrita Machwe, Li Chen, Vilhelm A. Bohr, David K. Orren

Nat Commun. 2015; 6: 8331. Published online 2015 Sep 30. doi: 10.1038/ncomms9331

PMCID:: PMC4589872

Abstract Article PDF–3.3M

Select item 45088912.

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

William C. Drosopoulos, Settapong T. Kosiyatrakul, Carl L. Schildkraut

J Cell Biol. 2015 Jul 20; 210(2): 191–208. doi: 10.1083/jcb.201410061

PMCID:: PMC4508891

Abstract Article PDF–3.9M

Select item 38249893.

Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population

Shengqun Jiang, Nan Hu, Jing Zhou, Junfang Zhang, Ruifang Gao, Jianyan Hu, Huaijin Guan

Age (Dordr) 2013 Dec; 35(6): 2435–2444. Published online 2013 Jan 20. doi: 10.1007/s11357-013-9512-4

PMCID:: PMC3824989

Abstract Article PDF–162K

Select item 32490704.

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

Avik K. Ghosh, Marie L. Rossi, Dharmendra Kumar Singh, Christopher Dunn, Mahesh Ramamoorthy, Deborah L. Croteau, Yie Liu, Vilhelm A. Bohr

J Biol Chem. 2012 Jan 2; 287(1): 196–209. Published online 2011 Oct 28. doi: 10.1074/jbc.M111.295063

PMCID:: PMC3249070

Abstract Article PDF–3.4M

Select item 31780595.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 29299416.

Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population

M. Ehrenberg, O. Dratviman-Storobinsky, B.R. Avraham-Lubin, N. Goldenberg-Cohen

Mol Vis. 2010; 16: 1771–1775. Published online 2010 Aug 28.

PMCID:: PMC2929941

Abstract Article PDF–1.1M

Select item 27815077.

Telomeric D-loops Containing 8-Oxo-2′-deoxyguanosine Are Preferred Substrates for Werner and Bloom Syndrome Helicases and Are Bound by POT1

Avik Ghosh, Marie L. Rossi, Jason Aulds, Deborah Croteau, Vilhelm A. Bohr

J Biol Chem. 2009 Nov 6; 284(45): 31074–31084. Published online 2009 Sep 4. doi: 10.1074/jbc.M109.027532

PMCID:: PMC2781507

Abstract Article PDF–2.2M

Select item 27060008.

Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet

Gina Moore, Susan Knoblaugh, Kathryn Gollahon, Peter Rabinovitch, Warren Ladiges

Mech Ageing Dev. Author manuscript; available in PMC 2009 Jul 6.

Published in final edited form as: Mech Ageing Dev. 2008 Apr; 129(4): 201–206. Published online 2008 Jan 17. doi: 10.1016/j.mad.2007.12.009

PMCID:: PMC2706000

Abstract Article PDF–678K

Select item 26940319.

c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress

Kristin Robinson, Nichaya Asawachaicharn, Denise A. Galloway, Carla Grandori

PLoS One. 2009; 4(6): e5951. Published online 2009 Jun 18. doi: 10.1371/journal.pone.0005951

PMCID:: PMC2694031

Abstract Article PDF–2.8M

Select item 226839410.

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2^ΔB-Mediated Telomere Shortening

Baomin Li, Sonali P. Jog, Sita Reddy, Lucio Comai

Mol Cell Biol. 2008 Mar; 28(6): 1892–1904. Published online 2008 Jan 22. doi: 10.1128/MCB.01364-07

PMCID:: PMC2268394

Abstract Article PDF–1.5M

Select item 203446411.

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

Nurten Saydam, Radhakrishnan Kanagaraj, Tobias Dietschy, Patrick L. Garcia, Javier Peña-Diaz, Igor Shevelev, Igor Stagljar, Pavel Janscak

Nucleic Acids Res. 2007 Sep; 35(17): 5706–5716. Published online 2007 Aug 22. doi: 10.1093/nar/gkm500

PMCID:: PMC2034464

Abstract Article PDF–2.3M

Select item 196552412.

Werner syndrome protein interacts functionally with translesion DNA polymerases

Ashwini S. Kamath-Loeb, Li Lan, Satoshi Nakajima, Akira Yasui, Lawrence A. Loeb

Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25): 10394–10399. Published online 2007 Jun 11. doi: 10.1073/pnas.0702513104

PMCID:: PMC1965524

Abstract Article PDF–721K

Select item 186841713.

The Spectrum of WRN Mutations in Werner Syndrome Patients

Shurong Huang, Lin Lee, Nancy B. Hanson, Catherine Lenaerts, Holger Hoehn, Martin Poot, Craig D. Rubin, Da-Fu Chen, Chih-Chao Yang, Heike Juch, Thomas Dorn, Roland Spiegel, Elif Arioglu Oral, Mohammed Abid, Carla Battisti, Emanuela Lucci-Cordisco, Giovanni Neri, Erin H. Steed, Alexa Kidd, William Isley, David Showalter, Janet L. Vittone, Alexander Konstantinow, Johannes Ring, Peter Meyer, Sharon L. Wenger, Axel von Herbay, Uwe Wollina, Markus Schuelke, Carin R. Huizenga, Dru F. Leistritz, George M. Martin, I. Saira Mian, Junko Oshima

Hum Mutat. Author manuscript; available in PMC 2007 May 14.

Published in final edited form as: Hum Mutat. 2006 Jun; 27(6): 558–567. doi: 10.1002/humu.20337

PMCID:: PMC1868417

Abstract Article PDF–865K

Select item 185118014.

Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice

Michel Lebel, Josée Lavoie, Isabelle Gaudreault, Marc Bronsard, Régen Drouin

Am J Pathol. 2003 May; 162(5): 1559–1569. doi: 10.1016/S0002-9440(10)64290-3

PMCID:: PMC1851180

Abstract Article PDF–369K

Select item 51675715.

Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes

Xiaobing Du, Johnny Shen, Nishan Kugan, Emma E. Furth, David B. Lombard, Catherine Cheung, Sally Pak, Guangbin Luo, Robert J. Pignolo, Ronald A. DePinho, Leonard Guarente, F. Brad Johnson

Mol Cell Biol. 2004 Oct; 24(19): 8437–8446. doi: 10.1128/MCB.24.19.8437-8446.2004

PMCID:: PMC516757

Abstract Article PDF–824K

Select item 31654516.

Ku complex interacts with and stimulates the Werner protein

Marcus P. Cooper, Amrita Machwe, David K. Orren, Robert M. Brosh, Dale Ramsden, Vilhelm A. Bohr

Genes Dev. 2000 Apr 15; 14(8): 907–912.

PMCID:: PMC316545

Abstract Article PDF–408K

Select item 19369017.

Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution

Wen-Hsing Cheng, Cayetano von Kobbe, Patricia L. Opresko, Kesha M. Fields, Jian Ren, Donald Kufe, Vilhelm A. Bohr

Mol Cell Biol. 2003 Sep; 23(18): 6385–6395. doi: 10.1128/MCB.23.18.6385-6395.2003

PMCID:: PMC193690

Abstract Article PDF–577K

Select item 10273918.

Characterization of the human and mouse WRN 3′→5′ exonuclease

Shurong Huang, Sergey Beresten, Baomin Li, Junko Oshima, Nathan A. Ellis, Judith Campisi

Nucleic Acids Res. 2000 Jun 15; 28(12): 2396–2405. doi: 10.1093/nar/28.12.2396

PMCID:: PMC102739

Abstract Article PDF–848K

Select item 10273119.

Potent inhibition of Werner and Bloom helicases by DNA minor groove binding drugs

Robert M. Brosh Jr, Julia K. Karow, E. James White, Natalie D. Shaw, Ian D. Hickson, Vilhelm A. Bohr

Nucleic Acids Res. 2000 Jun 15; 28(12): 2420–2430. doi: 10.1093/nar/28.12.2420

PMCID:: PMC102731

Abstract Article PDF–295K

Select item 8562220.

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

David B. Lombard, Caroline Beard, Brad Johnson, Robert A. Marciniak, Jessie Dausman, Roderick Bronson, Janet E. Buhlmann, Ruth Lipman, Ruth Curry, Arlene Sharpe, Rudolf Jaenisch, Leonard Guarente

Mol Cell Biol. 2000 May; 20(9): 3286–3291. doi: 10.1128/mcb.20.9.3286-3291.2000

PMCID:: PMC85622

Abstract Article PDF–797K

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