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Select item 98912761.

Inhibition of Bruton’s Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats

Nikita M. Patel, Filipe R. M. B. Oliveira, Hanna Pillmann Ramos, Eleonora Aimaretti, Gustavo Ferreira Alves, Sina M. Coldewey, Massimo Collino, Regina Sordi, Christoph Thiemermann

Ann Surg. 2023 Mar; 277(3): e624–e633. Published online 2021 Dec 27. doi: 10.1097/SLA.0000000000005357

PMCID:: PMC9891276

Abstract Article PDF–792K

Select item 72747612.

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

Mark Roschewski, Michail S. Lionakis, Jeff P. Sharman, Joseph Roswarski, Andre Goy, M. Andrew Monticelli, Michael Roshon, Stephen H. Wrzesinski, Jigar V. Desai, Marissa A. Zarakas, Jacob Collen, Keith Rose, Ahmed Hamdy, Raquel Izumi, George W. Wright, Kevin K. Chung, Jose Baselga, Louis M. Staudt, Wyndham H. Wilson

Sci Immunol. 2020 Jun 5; 5(48): eabd0110. doi: 10.1126/sciimmunol.abd0110

PMCID:: PMC7274761

Abstract Article PDF–1.9M

Select item 71759163.

BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining

Ke-Wei Bi, Xu-Ge Wei, Xiao-Xue Qin, Bo Li

Front Oncol. 2020; 10: 424. Published online 2020 Apr 15. doi: 10.3389/fonc.2020.00424

PMCID:: PMC7175916

Abstract Article PDF–2.3M

Select item 66271634.

Role of Bruton’s Tyrosine Kinase in Stage III Colorectal Cancer

Debora Basile, Lorenzo Gerratana, Angela Buonadonna, Silvio Ken Garattini, Tiziana Perin, Emanuela Grassilli, Gianmaria Miolo, Maria Grazia Cerrito, Claudio Belluco, Giulio Bertola, Antonino De Paoli, Renato Cannizzaro, Marialuisa Lavitrano, Fabio Puglisi, Vincenzo Canzonieri

Cancers (Basel) 2019 Jun; 11(6): 880. Published online 2019 Jun 24. doi: 10.3390/cancers11060880

PMCID:: PMC6627163

Abstract Article PDF–2.0M

Select item 65709065.

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, Federica Brena, Annamaria Cialdella, Leonarda Ianzano, Irene Forno, Maria Grazia Cerrito, Roberto Giovannoni, Gian Luca Ferri, Ennio Tasciotti, Silve Vicent, Francesco Damarco, Silvano Bosari, Marialuisa Lavitrano, Emanuela Grassilli

J Exp Clin Cancer Res. 2019; 38: 260. Published online 2019 Jun 14. doi: 10.1186/s13046-019-1199-7

PMCID:: PMC6570906

Abstract Article PDF–5.1M

Select item 63325496.

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll, Alex F. de Vos

Mol Med. 2019; 25: 3. Published online 2019 Jan 15. doi: 10.1186/s10020-018-0069-7

PMCID:: PMC6332549

Abstract Article PDF–2.7M

Select item 62877917.

Ibrutinib significantly inhibited Bruton’s tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model

Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R. Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven, Paul Galardy, Stanton C. Goldman, Megan S. Lim, Michelle Hermiston, Linda M. McAllister-Lucas, Lisa Giulino-Roth, Sherrie L. Perkins, Mitchell S. Cairo

Oncoimmunology. 2019; 8(1): e1512455. Published online 2018 Oct 11. doi: 10.1080/2162402X.2018.1512455

PMCID:: PMC6287791

Abstract Article PDF–2.0M

Select item 60878948.

Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury

Jon M. Florence, Agnieszka Krupa, Laela M. Booshehri, Sandra A. Davis, Michael A. Matthay, Anna K. Kurdowska

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1; 315(1): L52–L58. Published online 2018 Mar 8. doi: 10.1152/ajplung.00047.2018

PMCID:: PMC6087894

Abstract Article

Select item 57304059.

Non-receptor tyrosine kinases ITK and BTK negatively regulate mast cell pro-inflammatory responses to lipopolysaccharide

Weishan Huang, J. Luis Morales, Victor P. Gozivoda, Avery August

J Allergy Clin Immunol. Author manuscript; available in PMC 2017 Dec 14.

Published in final edited form as: J Allergy Clin Immunol. 2016 Apr; 137(4): 1197–1205. Published online 2015 Nov 12. doi: 10.1016/j.jaci.2015.08.056

PMCID:: PMC5730405

Abstract Article PDF–1.4M

Select item 557165010.

Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary Central Nervous System Lymphoma

Michail S. Lionakis, Kieron Dunleavy, Mark Roschewski, Brigitte C. Widemann, John A. Butman, Roland Schmitz, Diane E. Cole, Christopher Melani, Christine S. Higham, Jigar V. Desai, Michele Ceribelli, Lu Chen, Craig J. Thomas, Richard F. Little, Juan Gea-Banacloche, Sucharita Bhaumik, Maryalice Stetler-Stevenson, Stefania Pittaluga, Elaine S. Jaffe, John Heiss, Nicole Lucas, Seth M. Steinberg, Louis M. Staudt, Wyndham H. Wilson

Cancer Cell. Author manuscript; available in PMC 2018 Jun 12.

Published in final edited form as: Cancer Cell. 2017 Jun 12; 31(6): 833–843.e5. Published online 2017 May 25. doi: 10.1016/j.ccell.2017.04.012

PMCID:: PMC5571650

Abstract Article PDF–1.6M

Select item 554078711.

B-cell lymphoma patient-derived xenograft models enable drug discovery and are a platform for personalized therapy

Leo Zhang, Krystle Nomie, Hui Zhang, Taylor Bell, Lan Pham, Sabah Kadri, Jeremy Segal, Shaoying Li, Shouhao Zhou, David Santos, Shawana Richard, Shruti Sharma, Wendy Chen, Onyekachukwu Oriabure, Yang Liu, Shengjian Huang, Hui Guo, Zhihong Chen, Wenjing Tao, Carrie Li, Jack Wang, Bingliang Fang, Jacqueline Wang, Lei Li, Maria Badillo, Makhdum Ahmed, Selvi Thirumurthi, Steven Y. Huang, Yiping Shao, Laura Lam, Qing Yi, Y. Lynn Wang, Michael Wang

Clin Cancer Res. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Clin Cancer Res. 2017 Aug 1; 23(15): 4212–4223. Published online 2017 Mar 27. doi: 10.1158/1078-0432.CCR-16-2703

PMCID:: PMC5540787

Abstract Article PDF–1.6M

Select item 550516612.

Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

Ranjana H. Advani, Joseph J. Buggy, Jeff P. Sharman, Sonali M. Smith, Thomas E. Boyd, Barbara Grant, Kathryn S. Kolibaba, Richard R. Furman, Sara Rodriguez, Betty Y. Chang, Juthamas Sukbuntherng, Raquel Izumi, Ahmed Hamdy, Eric Hedrick, Nathan H. Fowler

J Clin Oncol. 2013 Jan 1; 31(1): 88–94. Published online 2012 Oct 8. doi: 10.1200/JCO.2012.42.7906

PMCID:: PMC5505166

Abstract Article PDF–310K

Select item 542850913.

Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Hong Wu, Qiong Huang, Ziping Qi, Yongfei Chen, Aoli Wang, Cheng Chen, Qianmao Liang, Jinghua Wang, Wensheng Chen, Jin Dong, Kailin Yu, Chen Hu, Wenchao Wang, Xiaochuan Liu, Yuanxin Deng, Li Wang, Beilei Wang, Xiaoxiang Li, Nathanael S. Gray, Jing Liu, Wei Wei, Qingsong Liu

Sci Rep. 2017; 7: 466. Published online 2017 Mar 28. doi: 10.1038/s41598-017-00482-4

PMCID:: PMC5428509

Abstract Article PDF–3.8M

Select item 437510514.

Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma

Idit Sagiv-Barfi, Holbrook E. Kohrt, Laura Burckhardt, Debra K. Czerwinski, Ronald Levy

Blood. 2015 Mar 26; 125(13): 2079–2086. Prepublished online 2015 Feb 6. doi: 10.1182/blood-2014-08-593137

PMCID:: PMC4375105

Abstract Article

Select item 422449115.

Intestinal Colonization by Candida albicans Alters Inflammatory Responses in Bruton's Tyrosine Kinase-Deficient Mice

Karin Strijbis, Ömer H. Yilmaz, Stephanie K. Dougan, Alexandre Esteban, Andrea Gröne, Carol A. Kumamoto, Hidde L. Ploegh

PLoS One. 2014; 9(11): e112472. Published online 2014 Nov 7. doi: 10.1371/journal.pone.0112472

PMCID:: PMC4224491

Abstract Article PDF–6.7M

Select item 370544816.

X-Linked Immunodeficient Mice Exhibit Enhanced Susceptibility to Cryptococcus neoformans Infection

Wendy A. Szymczak, Michael J. Davis, Steven K. Lundy, Chad Dufaud, Michal Olszewski, Liise-anne Pirofski

mBio. 2013 Jul-Aug; 4(4): e00265-13. Published online 2013 Jul 2. doi: 10.1128/mBio.00265-13

PMCID:: PMC3705448

Abstract Article PDF–2.1M

Select item 360975817.

The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection

Afitap Derya Köprülü, Renate Kastner, Sebastian Wienerroither, Caroline Lassnig, Eva Maria Putz, Olivia Majer, Benjamin Reutterer, Veronika Sexl, Karl Kuchler, Mathias Müller, Thomas Decker, Wilfried Ellmeier

PLoS One. 2013; 8(3): e60476. Published online 2013 Mar 27. doi: 10.1371/journal.pone.0060476

PMCID:: PMC3609758

Abstract Article PDF–590K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 219405519.

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

Elizabeth Clayton, Giuseppe Bardi, Sarah E. Bell, David Chantry, C. Peter Downes, Alexander Gray, Lisa A. Humphries, David Rawlings, Helen Reynolds, Elena Vigorito, Martin Turner

J Exp Med. 2002 Sep 16; 196(6): 753–763. doi: 10.1084/jem.20020805

PMCID:: PMC2194055

Abstract Article PDF–479K

Select item 41580720.

Fatal Disseminated Mouse Adenovirus Type 1 Infection in Mice Lacking B Cells or Bruton's Tyrosine Kinase

Martin L. Moore, Erin L. McKissic, Corrie C. Brown, John E. Wilkinson, Katherine R. Spindler

J Virol. 2004 Jun; 78(11): 5584–5590. doi: 10.1128/JVI.78.11.5584-5590.2004

PMCID:: PMC415807

Abstract Article PDF–2.1M

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