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Select item 68384021.

Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion

Petronila Penela, Javier Inserte, Paula Ramos, Antonio Rodriguez-Sinovas, David Garcia-Dorado, Federico Mayor, Jr

EBioMedicine. 2019 Oct; 48: 605–618. Published online 2019 Oct 5. doi: 10.1016/j.ebiom.2019.09.019

PMCID:: PMC6838402

Abstract Article PDF–2.2M

Select item 65759812.

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

JL Arriza, TM Dawson, RB Simerly, LJ Martin, MG Caron, SH Snyder, RJ Lefkowitz

J Neurosci. 1992 Oct 1; 12(10): 4045–4055. doi: 10.1523/JNEUROSCI.12-10-04045.1992

PMCID:: PMC6575981

Abstract PDF–2.8M

Select item 64028273.

Parathyroid hormone signaling in bone and kidney

Minnkyong Lee, Nicola C. Partridge

Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2019 Mar 6.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2009 Jul; 18(4): 298–302. doi: 10.1097/MNH.0b013e32832c2264

PMCID:: PMC6402827

Abstract Article PDF–303K

Select item 63379494.

G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes

Zhi-Hua Wan, Yuan-Jie Zhang, Lin Chen, Yong-Lian Guo, Guo-Hao Li, Ding Wu, Yong Wang

Asian J Androl. 2019 Jan-Feb; 21(1): 74–79. Published online 2018 Sep 14. doi: 10.4103/aja.aja_69_18

PMCID:: PMC6337949

Abstract Article PDF–1.8M

Select item 63350075.

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition

Sebastian Barreto Ortiz, Daijiro Hori, Yohei Nomura, Xin Yun, Haiyang Jiang, Hwanmee Yong, James Chen, Sam Paek, Deepesh Pandey, Gautam Sikka, Anil Bhatta, Andrew Gillard, Jochen Steppan, Jae Hyung Kim, Hideo Adachi, Viachaslau M. Barodka, Lewis Romer, Steven S. An, Larissa A. Shimoda, Lakshmi Santhanam, Dan E. Berkowitz

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1; 314(1): L93–L106. Published online 2017 Sep 7. doi: 10.1152/ajplung.00091.2017

PMCID:: PMC6335007

Abstract Article

Select item 60531766.

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V. Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A. Youker, Suresh S. Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L. Spiller, Kenichi Watanabe, Rajarajan A. Thandavarayan

PLoS One. 2018; 13(7): e0200697. Published online 2018 Jul 19. doi: 10.1371/journal.pone.0200697

PMCID:: PMC6053176

Abstract Article PDF–20M

Select item 60472307.

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β₂-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia

Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D’Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara, Giuseppe Rengo

J Pharmacol Exp Ther. 2016 Feb; 356(2): 503–513. Published online 2016 Feb. doi: 10.1124/jpet.115.228411

Correction in:: J Pharmacol Exp Ther. 2019 Apr; 369(1): 65.

PMCID:: PMC6047230

Abstract Article PDF–1.1M

Select item 57267598.

Biventricular differences in β-adrenergic receptor signaling following burn injury

Ashley N. Guillory, Robert P. Clayton, Anesh Prasai, Amina El Ayadi, David N. Herndon, Celeste C. Finnerty

PLoS One. 2017; 12(12): e0189527. Published online 2017 Dec 12. doi: 10.1371/journal.pone.0189527

PMCID:: PMC5726759

Abstract Article PDF–2.8M

Select item 55363629.

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy

Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M. Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J. Koch, Hugo A. Katus, Philip W. Raake

PLoS One. 2017; 12(7): e0182110. Published online 2017 Jul 31. doi: 10.1371/journal.pone.0182110

PMCID:: PMC5536362

Abstract Article PDF–21M

Select item 544810310.

Identification of a signaling cascade that maintains constitutive δ-opioid receptor incompetence in peripheral sensory neurons

Allison Doyle Brackley, Shayda Sarrami, Ruben Gomez, Kristi A. Guerrero, Nathaniel A. Jeske

J Biol Chem. 2017 May 26; 292(21): 8762–8772. Published online 2017 Apr 5. doi: 10.1074/jbc.M117.776799

PMCID:: PMC5448103

Abstract Article PDF–1.9M

Select item 541464811.

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells

Malika Jafferjee, Thairy Reyes Valero, Christine Marrero, Katie A. McCrink, Ava Brill, Anastasios Lymperopoulos

Mol Endocrinol. 2016 Mar; 30(3): 372–381. Published online 2016 Feb 5. doi: 10.1210/me.2015-1305

PMCID:: PMC5414648

Abstract Article

Select item 539766812.

Caveolin 1 and G-Protein–Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells

Songling Liu, Richard T. Premont, Shweta Singh, Don C. Rockey

Am J Pathol. 2017 Apr; 187(4): 896–907. doi: 10.1016/j.ajpath.2016.11.017

Correction in:: Am J Pathol. 2022 Feb; 192(2): 389.

PMCID:: PMC5397668

Abstract Article PDF–1.5M

Select item 536898013.

Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis

Qingtong Wang, Longsheng Wang, Li Wu, Mei Zhang, Shanshan Hu, Rui Wang, Yongsheng Han, Yujing Wu, Lingling Zhang, Xinming Wang, Wuyi Sun, Wei Wei

Sci Rep. 2017; 7: 45364. Published online 2017 Mar 28. doi: 10.1038/srep45364

PMCID:: PMC5368980

Abstract Article PDF–2.3M

Select item 534124214.

Endothelin‐1 suppresses insulin‐stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells

Takahiro Horinouchi, Akimasa Hoshi, Takuya Harada, Tsunaki Higa, Sarita Karki, Koji Terada, Tsunehito Higashi, Yosuke Mai, Prabha Nepal, Yuichi Mazaki, Soichi Miwa

Br J Pharmacol. 2016 Mar; 173(6): 1018–1032. Published online 2016 Feb 15. doi: 10.1111/bph.13406

PMCID:: PMC5341242

Abstract Article PDF–2.6M

Select item 516132715.

The Effects of Swiprosin-1 on the Formation of Pseudopodia-Like Structures and β-Adrenoceptor Coupling in Cultured Adult Rat Ventricular Cardiomyocytes

Franziska Nippert, Rolf Schreckenberg, Antonia Hess, Martin Weber, Klaus-Dieter Schlüter

PLoS One. 2016; 11(12): e0167655. Published online 2016 Dec 16. doi: 10.1371/journal.pone.0167655

PMCID:: PMC5161327

Abstract Article PDF–1.4M

Select item 508586416.

Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury

Meryl C. Woodall, Benjamin P. Woodall, Erhe Gao, Ancai Yuan, Walter J. Koch

Circ Res. Author manuscript; available in PMC 2017 Oct 28.

Published in final edited form as: Circ Res. 2016 Oct 28; 119(10): 1116–1127. Published online 2016 Sep 6. doi: 10.1161/CIRCRESAHA.116.309538

PMCID:: PMC5085864

Abstract Article PDF–2.9M

Select item 501466917.

GRK2 constitutively governs peripheral delta opioid receptor activity

Allison Doyle Brackley, Ruben Gomez, Armen N. Akopian, Michael A. Henry, Nathaniel A. Jeske

Cell Rep. Author manuscript; available in PMC 2016 Sep 7.

Published in final edited form as: Cell Rep. 2016 Sep 6; 16(10): 2686–2698. Published online 2016 Aug 25. doi: 10.1016/j.celrep.2016.07.084

PMCID:: PMC5014669

Abstract Article PDF–966K

Select item 495982718.

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling

David J. Polhemus, Juan Gao, Amy L. Scarborough, Rishi Trivedi, Kathleen H. McDonough, Traci T. Goodchild, Frank Smart, Daniel R. Kapusta, David J. Lefer

Circ Res. 2016 Jul 22; 119(3): 470–480. Published online 2016 Jul 21. doi: 10.1161/CIRCRESAHA.115.308278

PMCID:: PMC4959827

Abstract Article PDF–7.8M

Select item 483794919.

Regulation of Cellular Oxidative Stress and Apoptosis by G Protein-Coupled Receptor Kinase-2; The Role of NADPH Oxidase 4

Tiju Theccanat, Jennifer L. Philip, Md. Abdur Razzaque, Nicholas Ludmer, Jinju Li, Xianyao Xu, Shahab A. Akhter

Cell Signal. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Cell Signal. 2016 Mar; 28(3): 190–203. Published online 2015 Nov 27. doi: 10.1016/j.cellsig.2015.11.013

PMCID:: PMC4837949

Abstract Article PDF–3.1M

Select item 474791520.

Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats

Wenjuan Xing, Youyou Li, Haifeng Zhang, Chunjuan Mi, Zuoxu Hou, Michael J. Quon, Feng Gao

Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8): H1111–H1119. Published online 2013 Aug 2. doi: 10.1152/ajpheart.00290.2013

PMCID:: PMC4747915

Abstract Article

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