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Select item 60721821.

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome-mediated IL-1β secretion via c-Jun N-terminal kinase activation and cell apoptosis during diabetic nephropathy

Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen

Mol Med Rep. 2018 Aug; 18(2): 1995–2008. Published online 2018 Jun 14. doi: 10.3892/mmr.2018.9164

PMCID:: PMC6072182

Abstract Article PDF–2.2M

Select item 57274342.

SYK kinase mediates brown fat differentiation and activation

Marko Knoll, Sally Winther, Anirudh Natarajan, Huan Yang, Mengxi Jiang, Prathapan Thiru, Aliakbar Shahsafaei, Tony E. Chavarria, Dudley W. Lamming, Lei Sun, Jacob B. Hansen, Harvey F. Lodish

Nat Commun. 2017; 8: 2115. Published online 2017 Dec 13. doi: 10.1038/s41467-017-02162-3

PMCID:: PMC5727434

Abstract Article PDF–1.1M

Select item 53854893.

Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk

Chisato Honjoh, Kazuyasu Chihara, Hatsumi Yoshiki, Shota Yamauchi, Kenji Takeuchi, Yuji Kato, Yukio Hida, Tamotsu Ishizuka, Kiyonao Sada

Sci Rep. 2017; 7: 46064. Published online 2017 Apr 10. doi: 10.1038/srep46064

PMCID:: PMC5385489

Abstract Article PDF–1.6M

Select item 50771834.

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)³⁴⁶, a Regulatory Site of Syk

Kevin Reppschläger, Jeanne Gosselin, Carol A. Dangelmaier, Dafydd H. Thomas, Nick Carpino, Steven E. McKenzie, Satya P. Kunapuli, Alexander Y. Tsygankov

J Biol Chem. 2016 Oct 21; 291(43): 22427–22441. Published online 2016 Sep 8. doi: 10.1074/jbc.M116.743732

Correction in:: J Biol Chem. 2017 Mar 10; 292(10): 4360.

PMCID:: PMC5077183

Abstract Article PDF–3.2M

Select item 46983445.

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Attila Mócsai, Clare L Abram, Zoltán Jakus, Yongmei Hu, Lewis L Lanier, Clifford A Lowell

Nat Immunol. Author manuscript; available in PMC 2016 Jan 3.

Published in final edited form as: Nat Immunol. 2006 Dec; 7(12): 1326–1333. Published online 2006 Nov 5. doi: 10.1038/ni1407

PMCID:: PMC4698344

Abstract Article PDF–1.8M

Select item 45193576.

Mincle/Syk Signaling Pathway Contributes to Neuroinflammation after Subarachnoid Hemorrhage in Rats

Yue He, Liang Xu, Bo Li, Zhenni Guo, Qin Hu, Zongduo Guo, Junjia Tang, Yujie Chen, Yang Zhang, Jiping Tang, John H. Zhang

Stroke. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Stroke. 2015 Aug; 46(8): 2277–2286. Published online 2015 Jul 2. doi: 10.1161/STROKEAHA.115.010088

PMCID:: PMC4519357

Abstract Article PDF–2.8M

Select item 43523527.

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

Sharmila Ramessur Chandran, Greg H Tesch, Yingjie Han, Naomi Woodman, William R Mulley, John Kanellis, Kate Blease, Frank Y Ma, David J Nikolic-Paterson

Int J Exp Pathol. 2015 Feb; 96(1): 54–62. Published online 2014 Dec 22. doi: 10.1111/iep.12110

PMCID:: PMC4352352

Abstract Article PDF–1.1M

Select item 43264708.

Syk phosphorylation – a gravisensitive step in macrophage signalling

Sonja Brungs, Waldemar Kolanus, Ruth Hemmersbach

Cell Commun Signal. 2015; 13: 9. Published online 2015 Feb 3. doi: 10.1186/s12964-015-0088-8

PMCID:: PMC4326470

Abstract Article PDF–908K

Select item 42233539.

Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Spleen Tyrosine Kinase (Syk) in Rat Mast Cells

Yukihiro Kimura, Kazuyasu Chihara, Chisato Honjoh, Kenji Takeuchi, Shota Yamauchi, Hatsumi Yoshiki, Shigeharu Fujieda, Kiyonao Sada

J Biol Chem. 2014 Nov 7; 289(45): 31565–31575. Published online 2014 Sep 22. doi: 10.1074/jbc.M114.581322

PMCID:: PMC4223353

Abstract Article PDF–1.4M

Select item 417843810.

Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN

Stephen P. McAdoo, John Reynolds, Gurjeet Bhangal, Jennifer Smith, John P. McDaid, Anisha Tanna, William D. Jackson, Esteban S. Masuda, H. Terence Cook, Charles D. Pusey, Frederick W.K. Tam

J Am Soc Nephrol. 2014 Oct; 25(10): 2291–2302. Published online 2014 Apr 3. doi: 10.1681/ASN.2013090978

PMCID:: PMC4178438

Abstract Article

Select item 358629911.

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

Bryan Heit, Hani Kim, Gabriela Cosío, Diana Castaño, Richard Collins, Clifford A. Lowell, Kevin C. Kain, William S. Trimble, Sergio Grinstein

Dev Cell. Author manuscript; available in PMC 2014 Feb 25.

Published in final edited form as: Dev Cell. 2013 Feb 25; 24(4): 372–383. Published online 2013 Feb 7. doi: 10.1016/j.devcel.2013.01.007

PMCID:: PMC3586299

Abstract Article PDF–2.5M

Select item 349783312.

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Fatih M. Uckun, Hong Ma, Jian Zhang, Zahide Ozer, Sinisa Dovat, Cheney Mao, Rita Ishkhanian, Patricia Goodman, Sanjive Qazi

Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44): 18072–18077. Published online 2012 Oct 15. doi: 10.1073/pnas.1209828109

PMCID:: PMC3497833

Abstract Article PDF–801K

Select item 336681213.

Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)

Norihiro Ishida-Kitagawa, Kunitaro Tanaka, Xilinqiqige Bao, Takanori Kimura, Tadashi Miura, Yoshiki Kitaoka, Kouhei Hayashi, Mizuho Sato, Masahiro Maruoka, Takuya Ogawa, Jun Miyoshi, Tatsuo Takeya

J Biol Chem. 2012 May 18; 287(21): 17493–17502. Published online 2012 Mar 26. doi: 10.1074/jbc.M111.324194

PMCID:: PMC3366812

Abstract Article PDF–2.6M

Select item 332058614.

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

Rongze Lu, Hao Pan, John E. Shively

PLoS Pathog. 2012 Apr; 8(4): e1002597. Published online 2012 Apr 5. doi: 10.1371/journal.ppat.1002597

PMCID:: PMC3320586

Abstract Article PDF–2.6M

Select item 324356415.

Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses

Sara Gorjestani, Mei Yu, Bing Tang, Dekai Zhang, Demin Wang, Xin Lin

J Biol Chem. 2011 Dec 23; 286(51): 43651–43659. Published online 2011 Oct 31. doi: 10.1074/jbc.M111.307389

PMCID:: PMC3243564

Abstract Article PDF–1.1M

Select item 321721116.

CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4

Ivan Zanoni, Renato Ostuni, Lorri R. Marek, Simona Barresi, Roman Barbalat, Gregory M. Barton, Fancesca Granucci, Jonathan C. Kagan

Cell. Author manuscript; available in PMC 2012 Nov 11.

Published in final edited form as: Cell. 2011 Nov 11; 147(4): 868–880. doi: 10.1016/j.cell.2011.09.051

PMCID:: PMC3217211

Article PDF–3.0M

Select item 319107317.

Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation

Cuneyt K. Buharalioglu, Chi Young Song, Fariborz A. Yaghini, Hafiz U. B. Ghafoor, Mustafa Motiwala, Tusita Adris, Anne M. Estes, Kafait U. Malik

Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3): H1043–H1055. Published online 2011 Jun 3. doi: 10.1152/ajpheart.01018.2010

PMCID:: PMC3191073

Abstract Article

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 298267919.

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

Farhad Abtahian, Anastasia Guerriero, Eric Sebzda, Min-Min Lu, Rong Zhou, Attila Mocsai, Erin E. Myers, Bin Huang, David G. Jackson, Victor A. Ferrari, Victor Tybulewicz, Clifford A. Lowell, John J. Lepore, Gary A. Koretzky, Mark L. Kahn

Science. Author manuscript; available in PMC 2010 Nov 16.

Published in final edited form as: Science. 2003 Jan 10; 299(5604): 247–251. doi: 10.1126/science.1079477