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Select item 111617871.

CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche

Ting Qiu, Yichao Kong, Guifeng Wei, Kai Sun, Ruijie Wang, Yang Wang, Yiji Chen, Wenxin Wang, Yun Zhang, Caihong Jiang, Peiguo Yang, Tian Xie, Xiabin Chen

Proc Natl Acad Sci U S A. 2024 Jun 4; 121(23): e2322359121. Published online 2024 May 28. doi: 10.1073/pnas.2322359121

PMCID:: PMC11161787

Abstract Article PDF–3.2M

Select item 111599702.

Analysis of DOK‐6 function in downstream signaling of RET in human neuroblastoma cells

Ai Kurotsuchi, Yoshiki Murakumo, Mayumi Jijiwa, Kei Kurokawa, Yasutomo Itoh, Yoshinori Kodama, Takuya Kato, Atsushi Enomoto, Naoya Asai, Hiroko Terasaki, Masahide Takahashi

Cancer Sci. 2010 May; 101(5): 1147–1155. Published online 2010 Feb 3. doi: 10.1111/j.1349-7006.2010.01520.x

PMCID:: PMC11159970

Abstract Article PDF–646K

Select item 111589753.

Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase

Maki Ishida, Masatoshi Ichihara, Shinji Mii, Mayumi Jijiwa, Naoya Asai, Atsushi Enomoto, Takuya Kato, Ai Majima, Jiang Ping, Yoshiki Murakumo, Masahide Takahashi

Cancer Sci. 2007 Jun; 98(6): 815–821. Published online 2007 Mar 27. doi: 10.1111/j.1349-7006.2007.00457.x

PMCID:: PMC11158975

Abstract Article PDF–275K

Select item 111580884.

Expression of Ret finger protein correlates with outcomes in endometrial cancer

Hirohisa Tsukamoto, Takuya Kato, Atsushi Enomoto, Nobuhisa Nakamura, Yohei Shimono, Mayumi Jijiwa, Naoya Asai, Yoshiki Murakumo, Kiyosumi Shibata, Fumitaka Kikkawa, Masahide Takahashi

Cancer Sci. 2009 Oct; 100(10): 1895–1901. Published online 2009 Jul 10. doi: 10.1111/j.1349-7006.2009.01278.x

PMCID:: PMC11158088

Abstract Article PDF–3.4M

Select item 111580815.

RET protein promotes non‐adherent growth of NB‐39‐nu neuroblastoma cell line

Hitoyasu Futami, Ryuichi Sakai

Cancer Sci. 2009 Jun; 100(6): 1034–1039. Published online 2009 Feb 20. doi: 10.1111/j.1349-7006.2009.01143.x

PMCID:: PMC11158081

Abstract Article PDF–1.9M

Select item 110881696.

Next-generation sequencing identified that RET variation associates with lymph node metastasis and the immune microenvironment in thyroid papillary carcinoma

Yongsheng Huang, Peiliang Lin, Jianwei Liao, Faya Liang, Ping Han, Sha Fu, Yuanling Jiang, Zhifan Yang, Ni Tan, Jinghua Huang, Renhui Chen, Nengtai Ouyang, Xiaoming Huang

BMC Endocr Disord. 2024; 24: 68. Published online 2024 May 11. doi: 10.1186/s12902-024-01586-5

PMCID:: PMC11088169

Abstract Article PDF–8.5M

Select item 110339487.

Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling

Laura Schubert, Anh T. Le, Adriana Estrada-Bernal, Andrea E. Doak, Minjae Yoo, Sarah E. Ferrara, Andrew Goodspeed, Fumi Kinose, Uwe Rix, Aik-Choon Tan, Robert C. Doebele

Mol Pharmacol. 2021 Jun; 99(6): 435–447. Published online 2021 Jun. doi: 10.1124/molpharm.120.000207

PMCID:: PMC11033948

Abstract Article PDF–1.9M

Select item 109438008.

Aberrant SOX10 and RET expressions in patients with Hirschsprung disease

Gunadi, Verrell Christopher Amadeus, Fadila Dyah Trie Utami, Fiqih Vidiantoro Halim, Nabilah Anisa Novebri, Rahaditya Alrasyidi Hanggoro, Avinindita Nura Lestari, Kristy Iskandar, Andi Dwihantoro, Eko Purnomo

BMC Pediatr. 2024; 24: 189. Published online 2024 Mar 16. doi: 10.1186/s12887-024-04682-6

PMCID:: PMC10943800

Abstract Article PDF–1.0M

Select item 108136909.

GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex

Baikang Xie, Wenjing Tang, Shuang Wen, Fen Chen, Chao Yang, Min Wang, Yong Yang, Wei Liang

Biomolecules. 2024 Jan; 14(1): 38. Published online 2023 Dec 27. doi: 10.3390/biom14010038

PMCID:: PMC10813690

Abstract Article PDF–2.4M

Select item 1065602010.

Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling

Ronit Marom, Bo Zhang, Megan E. Washington, I-Wen Song, Lindsay C. Burrage, Vittoria C. Rossi, Ava S. Berrier, Anika Lindsey, Jacob Lesinski, Michael L. Nonet, Jian Chen, Dustin Baldridge, Gary A. Silverman, V. Reid Sutton, Jill A. Rosenfeld, Alyssa A. Tran, M. John Hicks, David R. Murdock, Hongzheng Dai, MaryAnn Weis, Shalini N. Jhangiani, Donna M. Muzny, Richard A. Gibbs, Richard Caswell, Carrie Pottinger, Deirdre Cilliers, Karen Stals, Undiagnosed Diseases Network, David Eyre, Deborah Krakow, Tim Schedl, Stephen C. Pak, Brendan H. Lee

PLoS Genet. 2023 Nov; 19(11): e1011005. Published online 2023 Nov 7. doi: 10.1371/journal.pgen.1011005

PMCID:: PMC10656020

Abstract Article PDF–3.1M

Select item 1064692711.

Clinical characteristics of a large familial cohort with Medullary thyroid cancer and germline Cys618Arg RET mutation in an Israeli multicenter study

Rachel Chava Rosenblum, Dania Hirsch, Simona Grozinsky-Glasberg, Carlos Benbassat, Uri Yoel, Avraham Ishay, Sagit Zolotov, Gideon Bachar, Ehud Banne, Sigal Levy, Orit Twito

Front Endocrinol (Lausanne) 2023; 14: 1268193. Published online 2023 Oct 30. doi: 10.3389/fendo.2023.1268193

PMCID:: PMC10646927

Abstract Article PDF–889K

Select item 1064152412.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 1063763013.

TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

Qianjin Guo, Zi-Ming Cheng, Hector Gonzalez-Cantú, Matthew Rotondi, Gabriela Huelgas-Morales, Purushoth Ethiraj, Zhijun Qiu, Jonathan Lefkowitz, Wan Song, Bethany N. Landry, Hector Lopez, Cynthia M. Estrada-Zuniga, Shivi Goyal, Mohammad Aasif Khan, Timothy J. Walker, Exing Wang, Faqian Li, Yanli Ding, Lois M. Mulligan, Ricardo C.T. Aguiar, Patricia L.M. Dahia

Cell Rep. Author manuscript; available in PMC 2023 Nov 10.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113070. Published online 2023 Sep 1. doi: 10.1016/j.celrep.2023.113070

PMCID:: PMC10637630

Abstract Article PDF–3.2M

Select item 1048053514.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 1035812815.

Extended RET Gene Analysis in Patients with Apparently Sporadic Medullary Thyroid Cancer: Clinical Benefits and Cost

Susan C. Lindsey, Ilda S. Kunii, Fausto Germano-Neto, Misaki Y. Sittoni, Cléber P. Camacho, Flávia O. F. Valente, Ji H. Yang, Priscila S. Signorini, Rosana Delcelo, Janete M. Cerutti, Rui M. B. Maciel, Magnus R. Dias-da-Silva

Horm Cancer. 2012 Aug; 3(4): 181–186. Published online 2012 May 31. doi: 10.1007/s12672-012-0109-7

PMCID:: PMC10358128

Abstract Article PDF–402K

Select item 1035810116.

Somatic Mutation Analysis of the SDHB, SDHC, SDHD, and RET Genes in the Clinical Assessment of Sporadic and Hereditary Pheochromocytoma

Alexander Weber, Michael M. Hoffmann, Hartmut P. H. Neumann, Zoran Erlic

Horm Cancer. 2012 Aug; 3(4): 187–192. Published online 2012 May 10. doi: 10.1007/s12672-012-0113-y

PMCID:: PMC10358101

Abstract Article PDF–154K

Select item 1035570917.

The Combination of RET, BRAF and Demographic Data Identifies Subsets of Patients with Aggressive Papillary Thyroid Cancer

Jose R. W. Martínez, Sergio Vargas-Salas, Soledad Urra Gamboa, Estefanía Muñoz, José Miguel Domínguez, Augusto León, Nicolás Droppelmann, Antonieta Solar, Mark Zafereo, F. Christopher Holsinger, Hernán E. González

Horm Cancer. 2019 Jun; 10(2-3): 97–106. Published online 2019 Mar 22. doi: 10.1007/s12672-019-0359-8

PMCID:: PMC10355709

Abstract Article PDF–571K

Select item 1032325218.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 1023742219.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1018225620.

High Expression of the RET Receptor Tyrosine Kinase and Its Ligand GDNF Identifies a High-Risk Subset of Estrogen Receptor Positive Breast Cancer

Rasha T. Kakati, Hyunsoo Kim, Austin Whitman, Philip M. Spanheimer

Breast Cancer Res Treat. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Breast Cancer Res Treat. 2023 Jun; 199(3): 589–601. Published online 2023 Apr 15. doi: 10.1007/s10549-023-06937-9

PMCID:: PMC10182256

Abstract Article PDF–1.5M

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