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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 98256593.

Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature

Richard H. van Jaarsveld, Jack Reilly, Marie-Claire Cornips, Michael A. Hadders, Emanuele Agolini, Priyanka Ahimaz, Kwame Anyane-Yeboa, Severine Audebert Bellanger, Ellen van Binsbergen, Marie-Jose van den Boogaard, Elise Brischoux-Boucher, Raymond C. Caylor, Andrea Ciolfi, Ton A.J. van Essen, Paolo Fontana, Saskia Hopman, Maria Iascone, Margaret M. Javier, Erik-Jan Kamsteeg, Jennifer Kerkhof, Jun Kido, Hyung-Goo Kim, Tjitske Kleefstra, Fortunato Lonardo, Abbe Lai, Dorit Lev, Michael A. Levy, M.E. Suzanne Lewis, Angie Lichty, Marcel M.A.M. Mannens, Naomichi Matsumoto, Idit Maya, Haley McConkey, Andre Megarbane, Vincent Michaud, Evelina Miele, Marcello Niceta, Antonio Novelli, Roberta Onesimo, Rolph Pfundt, Bernt Popp, Eloise Prijoles, Raissa Relator, Sylvia Redon, Dmitrijs Rots, Karen Rouault, Ken Saida, Jolanda Schieving, Marco Tartaglia, Romano Tenconi, Kevin Uguen, Nienke Verbeek, Christopher A. Walsh, Keren Yosovich, Christopher J. Yuskaitis, Giuseppe Zampino, Bekim Sadikovic, Mariëlle Alders, Renske Oegema

Genet Med. Author manuscript; available in PMC 2023 Jan 8.

Published in final edited form as: Genet Med. 2022 Nov 1 : S1098-3600(22)00942-X. Published online 2022 Nov 1. doi: 10.1016/j.gim.2022.09.006

PMCID:: PMC9825659

Abstract Article PDF–1.7M

Select item 97696984.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 95403455.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 93383136.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 88288957.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 88101348.

Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway

Zhonghai Xie, Hongwei Li, Jin Zang

Bioengineered. 2021; 12(2): 12227–12235. Published online 2021 Dec 7. doi: 10.1080/21655979.2021.2005931

PMCID:: PMC8810134

Abstract Article PDF–2.2M

Select item 87633179.

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation

Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley

Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h

PMCID:: PMC8763317

Abstract Article

Select item 854480010.

Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease

Sarah J. Wong, Olga Senkovich, Jason A. Artigas, Micah D. Gearhart, Udayar Ilangovan, David W. Graham, Kelsey N. Abel, Tianrong Yu, Andrew P. Hinck, Vivian J. Bardwell, Chongwoo A. Kim

Biochemistry. Author manuscript; available in PMC 2021 Oct 25.

Published in final edited form as: Biochemistry. 2020 Jul 28; 59(29): 2718–2728. Published online 2020 Jul 10. doi: 10.1021/acs.biochem.0c00285

PMCID:: PMC8544800

Abstract Article PDF–1.1M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813968812.

KDM2B Overexpression Facilitates Lytic De Novo Kaposi's Sarcoma-Associated Herpesvirus Infection by Inducing AP-1 Activity through Interaction with the SCF E3 Ubiquitin Ligase Complex

Nenavath Gopal Naik, See-Chi Lee, Juan D. Alonso, Zsolt Toth

J Virol. 2021 Jun; 95(11): e00331-21. Prepublished online 2021 Mar 10. Published online 2021 May 10. doi: 10.1128/JVI.00331-21

PMCID:: PMC8139688

Abstract Article PDF–3.2M

Select item 808076413.

SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation

Duk-Hwa Kwon, Joo-Young Kang, Hosouk Joung, Ji-Young Kim, Anna Jeong, Hyun-Ki Min, Sera Shin, Yun-Gyeong Lee, Young-Kook Kim, Sang-Beom Seo, Hyun Kook

Exp Mol Med. 2021 Feb; 53(2): 250–263. Published online 2021 Feb 9. doi: 10.1038/s12276-021-00564-4

PMCID:: PMC8080764

Abstract Article PDF–2.1M

Select item 805077514.

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner

Lauriane Vélot, Frédéric Lessard, Félix-Antoine Bérubé-Simard, Christophe Tav, Bertrand Neveu, Valentine Teyssier, Imène Boudaoud, Ugo Dionne, Noémie Lavoie, Steve Bilodeau, Frédéric Pouliot, Nicolas Bisson

Mol Cell Proteomics. 2021; 20: 100064. Published online 2021 Feb 26. doi: 10.1016/j.mcpro.2021.100064

PMCID:: PMC8050775

Abstract Article PDF–3.6M

Select item 794848715.

KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial–mesenchymal transition in lung and pancreatic cancer cell lines

Sasithorn Wanna-Udom, Minoru Terashima, Kusuma Suphakhong, Akihiko Ishimura, Takahisa Takino, Takeshi Suzuki

J Biol Chem. 2021 Jan-Jun; 296: 100213. Published online 2020 Dec 24. doi: 10.1074/jbc.RA120.015502

PMCID:: PMC7948487

Abstract Article PDF–4.3M

Select item 789358716.

The histone demethylase KDM2B regulates human primordial germ cell-like cells specification

Weiyan Yuan, Zhaokai Yao, Veeramohan Veerapandian, Xinyan Yang, Xiaoman Wang, Dingyao Chen, Linzi Ma, Chaohui Li, Yi Zheng, Fang Luo, Xiao-yang Zhao

Int J Biol Sci. 2021; 17(2): 527–538. Published online 2021 Jan 1. doi: 10.7150/ijbs.55873

PMCID:: PMC7893587

Abstract Article PDF–2.2M

Select item 778001417.

Inhibition of microRNA let‐7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer

Yan Kuang, Hong Xu, Fangfang Lu, Jiahua Meng, Yeye Yi, Huilan Yang, Hairui Hou, Hao Wei, Shanheng Su

Cancer Sci. 2021 Jan; 112(1): 231–242. Published online 2020 Nov 21. doi: 10.1111/cas.14708

Correction in:: Cancer Sci. 2024 Oct; 115(10): 3492–3494.

PMCID:: PMC7780014

Abstract Article PDF–1.8M

Select item 765326418.

Histone H3K79 demethylation by KDM2B facilitates proper DNA replication through PCNA dissociation from chromatin

Joo‐Young Kang, Jin Woo Park, Ja Young Hahm, Hyeonsoo Jung, Sang‐Beom Seo

Cell Prolif. 2020; 53(11): e12920. Published online 2020 Oct 7. doi: 10.1111/cpr.12920

PMCID:: PMC7653264

Abstract Article PDF–1.4M

Select item 751545319.

The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility

Nefeli Zacharopoulou, Galatea Kallergi, Saad Alkahtani, Anna Tsapara, Saud Alarifi, Evi Schmid, Basma Sukkar, Sotirios Kampranis, Florian Lang, Christos Stournaras

Cancer Biol Ther. 2020; 21(6): 533–540. Published online 2020 Mar 16. doi: 10.1080/15384047.2020.1736481

PMCID:: PMC7515453

Abstract Article PDF–5.4M

Select item 732206720.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

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