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Items: 1 to 20 of 101

1.
Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia
Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotter
Brain. 2024 Oct; 147(10): 3547–3561. Published online 2024 May 4. doi: 10.1093/brain/awae140
PMCID:
PMC11449146
AbstractArticlePDF–974K
2.
Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B
K. Hochrainer, R. Kroismayr, U. Baranyi, B. R. Binder, J. Lipp
Cell Mol Life Sci. 2008 Jul; 65(13): 2105–2117. Published online 2008 Jun 6. doi: 10.1007/s00018-008-8148-5
PMCID:
PMC11131906
AbstractArticlePDF–2.0M
3.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
4.
Distribution of ubiquilin 2 and TDP‐43 aggregates throughout the CNS in UBQLN2 p.T487I‐linked amyotrophic lateral sclerosis and frontotemporal dementia
Laura R. Nementzik, Kyrah M. Thumbadoo, Helen C. Murray, David Gordon, Shu Yang, Ian P. Blair, Clinton Turner, Richard L. M. Faull, Maurice A. Curtis, Catriona McLean, Garth A. Nicholson, Molly E. V. Swanson, Emma L. Scotter
Brain Pathol. 2024 May; 34(3): e13230. Published online 2023 Dec 19. doi: 10.1111/bpa.13230
PMCID:
PMC11007053
AbstractArticlePDF–3.6M
5.
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson
EMBO Rep. 2024 Feb; 25(2): 902–926. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00043-z
PMCID:
PMC10897489
AbstractArticlePDF–8.2M
6.
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units
Sarasi K. K. Galagedera, Thuy P. Dao, Suzanne E. Enos, Antara Chaudhuri, Jeremy D. Schmit, Carlos A. Castañeda
Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2306638120. Published online 2023 Oct 12. doi: 10.1073/pnas.2306638120
PMCID:
PMC10589717
AbstractArticlePDF–1.5M
7.
Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid–Liquid Phase Separation
Christina Glen Robb, Thuy P. Dao, Jakub Ujma, Carlos A. Castañeda, Rebecca Beveridge
J Am Chem Soc. 2023 Jun 14; 145(23): 12541–12549. Published online 2023 Jun 5. doi: 10.1021/jacs.3c00756
PMCID:
PMC10273310
AbstractArticlePDF–3.6M
8.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
9.
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure
Gwen R. Buel, Xiang Chen, Wazo Myint, Olumide Kayode, Varvara Folimonova, Anthony Cruz, Katarzyna A Skorupka, Hiroshi Matsuo, Kylie J. Walters
Structure. Author manuscript; available in PMC 2024 Apr 6.
Published in final edited form as: Structure. 2023 Feb 14 : S0969-2126(23)00033-3. Published online 2023 Feb 14. doi: 10.1016/j.str.2023.01.012
PMCID:
PMC10081965
AbstractArticlePDF–3.1M
10.
UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
Holly H Black, Jessica L Hanson, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
eLife. 2023; 12: e79452. Published online 2023 Mar 23. doi: 10.7554/eLife.79452
PMCID:
PMC10076021
AbstractArticlePDF–4.2M
11.
A proteome-scale map of the SARS-CoV-2–human contactome
Dae-Kyum Kim, Benjamin Weller, Chung-Wen Lin, Dayag Sheykhkarimli, Jennifer J. Knapp, Guillaume Dugied, Andreas Zanzoni, Carles Pons, Marie J. Tofaute, Sibusiso B. Maseko, Kerstin Spirohn, Florent Laval, Luke Lambourne, Nishka Kishore, Ashyad Rayhan, Mayra Sauer, Veronika Young, Hridi Halder, Nora Marín-de la Rosa, Oxana Pogoutse, Alexandra Strobel, Patrick Schwehn, Roujia Li, Simin T. Rothballer, Melina Altmann, Patricia Cassonnet, Atina G. Coté, Lena Elorduy Vergara, Isaiah Hazelwood, Betty B. Liu, Maria Nguyen, Ramakrishnan Pandiarajan, Bushra Dohai, Patricia A. Rodriguez Coloma, Juline Poirson, Paolo Giuliana, Luc Willems, Mikko Taipale, Yves Jacob, Tong Hao, David E. Hill, Christine Brun, Jean-Claude Twizere, Daniel Krappmann, Matthias Heinig, Claudia Falter, Patrick Aloy, Caroline Demeret, Marc Vidal, Michael A. Calderwood, Frederick P. Roth, Pascal Falter-Braun
Nat Biotechnol. 2023; 41(1): 140–149. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01475-z
PMCID:
PMC9849141
AbstractArticlePDF–7.1M
12.
Silencing UBQLN2 Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma (ESCC) via Activating p38 MAPK
Jia-Lin Wang, Xiao-Ying Mu, Rong Ma, Xue-Hong Bai, Zhi-Jun Zhao, Yan-Yang Wang
J Oncol. 2023; 2023: 2339732. Published online 2023 Jan 5. doi: 10.1155/2023/2339732
PMCID:
PMC9836790
AbstractArticlePDF–2.2M
13.
UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding
Trong H. Phung, Micaela Tatman, Mervyn J. Monteiro
Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2023 Feb; 1867(2): 130284. Published online 2022 Nov 21. doi: 10.1016/j.bbagen.2022.130284
PMCID:
PMC9792439
AbstractArticlePDF–1.8M
14.
Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2P497H Mutation
Yiti Zhang, Baitao Zeng, Ao Gu, Qinyu Kang, Mingri Zhao, Guangnan Peng, Miaojin Zhou, Wanxi Liu, Min Liu, Lingjie Ding, Desheng Liang, Xionghao Liu, Mujun Liu
Int J Mol Sci. 2022 Oct; 23(19): 11333. Published online 2022 Sep 26. doi: 10.3390/ijms231911333
PMCID:
PMC9570184
AbstractArticlePDF–8.0M
15.
SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han
Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6
PMCID:
PMC9523645
AbstractArticlePDF–3.9M
16.
Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner
Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1
PMCID:
PMC9481602
AbstractArticlePDF–3.7M
17.
The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2
Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue
Theranostics. 2022; 12(14): 6363–6379. Published online 2022 Aug 29. doi: 10.7150/thno.74600
PMCID:
PMC9475453
AbstractArticlePDF–4.4M
18.
RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control
Harihar Milaganur Mohan, Hanna Trzeciakiewicz, Amit Pithadia, Emily V. Crowley, Regina Pacitto, Nathaniel Safren, Bryce Trotter, Chengxin Zhang, Xiaogen Zhou, Yang Zhang, Venkatesha Basrur, Henry L. Paulson, Lisa M. Sharkey
Cell Mol Life Sci. 2022 Mar; 79(3): 176. Published online 2022 Mar 5. doi: 10.1007/s00018-022-04170-z
PMCID:
PMC9376861
AbstractArticlePDF–6.1M
19.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
20.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M

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