PMC Links for GEO Profiles (Select 92168849) - PMC

Select item 113167091.

Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes

Blaž Kociper, Nives Škorja Milić, Ivana Ogrizek, Katarina Miš, Sergej Pirkmajer

J Muscle Res Cell Motil. 2024; 45(3): 155–169. Published online 2024 Jul 31. doi: 10.1007/s10974-024-09679-3

PMCID:: PMC11316709

Abstract Article PDF–4.9M

Select item 111362532.

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

T. E. Roche, Y. Hiromasa

Cell Mol Life Sci. 2007 Apr; 64(7-8): 830. Published online 2007 Feb 19. doi: 10.1007/s00018-007-6380-z

PMCID:: PMC11136253

Abstract Article PDF–855K

Select item 72748613.

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis

Lian Tian, Danchen Wu, Asish Dasgupta, Kuang-Hueih Chen, Jeffrey Mewburn, Francois Potus, Patricia A.D. Lima, Zhigang Hong, Yuan-Yuan Zhao, Charles C.T. Hindmarch, Shelby Kutty, Steeve Provencher, Sebastien Bonnet, Gopinath Sutendra, Stephen L. Archer

Circ Res. Author manuscript; available in PMC 2021 Jun 5.

Published in final edited form as: Circ Res. 2020 Jun 5; 126(12): 1723–1745. Published online 2020 Mar 27. doi: 10.1161/CIRCRESAHA.120.316443

PMCID:: PMC7274861

Abstract Article PDF–3.1M

Select item 63742104.

Structural Analysis of Hippocampal Kinase Signal Transduction

Daniel B. McClatchy, Nam-Kyung Yu, Salvador Martínez-Bartolomé, Reesha Patel, Alexander R. Pelletier, Mathieu Lavalle-Adam, Susan B. Powell, Marissa Roberto, John R. Yates

ACS Chem Neurosci. Author manuscript; available in PMC 2019 Apr 17.

Published in final edited form as: ACS Chem Neurosci. 2018 Dec 19; 9(12): 3072–3085. Published online 2018 Aug 13. doi: 10.1021/acschemneuro.8b00284

PMCID:: PMC6374210

Abstract Article PDF–1.4M

Select item 51020235.

Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis

Bo Gao, Wang Sun, Xianzhi Meng, Dongbo Xue, Weihui Zhang

Mol Med Rep. 2016 Nov; 14(5): 4629–4637. Published online 2016 Oct 12. doi: 10.3892/mmr.2016.5837

PMCID:: PMC5102023

Abstract Article PDF–972K

Select item 45892496.

Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes

Yuki Abe, Hiroshi Uchinami, Kazuhiro Kudoh, Yasuhiko Nakagawa, Norihito Ise, Go Watanabe, Tsutomu Sato, Ekihiro Seki, Yuzo Yamamoto

Surgery. Author manuscript; available in PMC 2015 Sep 30.

Published in final edited form as: Surgery. 2012 Nov; 152(5): 869–878. Published online 2012 May 8. doi: 10.1016/j.surg.2012.03.003

PMCID:: PMC4589249

Abstract Article PDF–1.4M

Select item 42957937.

Elucidation of the Interaction Loci of the Human Pyruvate Dehydrogenase Complex E2·E3BP Core with Pyruvate Dehydrogenase Kinase 1 and Kinase 2 by H/D Exchange Mass Spectrometry and Nuclear Magnetic Resonance

Junjie Wang, Sowmini Kumaran, Jieyu Zhou, Natalia S. Nemeria, Hu Tao, Lazaros Kakalis, Yun-Hee Park, Barbara Birkaya, Mulchand S. Patel, Frank Jordan

Biochemistry. 2015 Jan 13; 54(1): 69–82. Published online 2014 Dec 1. doi: 10.1021/bi5013113

PMCID:: PMC4295793

Abstract Article PDF–5.1M

Select item 38964888.

Complex Regulation of PKCβ2 and PDK-1/AKT by ROCK2 in Diabetic Heart

Guorong Lin, Roger W. Brownsey, Kathleen M. MacLeod

PLoS One. 2014; 9(1): e86520. Published online 2014 Jan 20. doi: 10.1371/journal.pone.0086520

PMCID:: PMC3896488

Abstract Article PDF–4.4M

Select item 32462189.

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Zhuo (Georgia) Chen, Titus J. Boggon, Sagar Lonial, Haian Fu, Fadlo R. Khuri, Sumin Kang, Jing Chen

Mol Cell. Author manuscript; available in PMC 2012 Dec 23.

Published in final edited form as: Mol Cell. 2011 Dec 23; 44(6): 864–877. doi: 10.1016/j.molcel.2011.10.015

PMCID:: PMC3246218

Abstract Article PDF–1.3M

Select item 317805910.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 315721011.

Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer

Chun-Wun Lu, Shau-Chieh Lin, Chun-Wei Chien, Shih-Chieh Lin, Chung-Ta Lee, Bo-Wen Lin, Jenq-Chang Lee, Shaw-Jenq Tsai

Am J Pathol. 2011 Sep; 179(3): 1405–1414. doi: 10.1016/j.ajpath.2011.05.050

PMCID:: PMC3157210

Abstract Article PDF–2.4M

Select item 287138512.

Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol

Masato Kato, Jun Li, Jacinta L. Chuang, David T. Chuang

Structure. Author manuscript; available in PMC 2010 May 17.

Published in final edited form as: Structure. 2007 Aug; 15(8): 992–1004. Published online 2007 Aug 2. doi: 10.1016/j.str.2007.07.001

PMCID:: PMC2871385

Abstract Article PDF–3.2M

Select item 277884413.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016

PMCID:: PMC2778844

Abstract Article PDF–1.2M

Select item 250489714.

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

Thomas McFate, Ahmed Mohyeldin, Huasheng Lu, Jay Thakar, Jeremy Henriques, Nader D. Halim, Hong Wu, Michael J. Schell, Tsz Mon Tsang, Orla Teahan, Shaoyu Zhou, Joseph A. Califano, Nam Ho Jeoung, Robert A. Harris, Ajay Verma

J Biol Chem. 2008 Aug 15; 283(33): 22700–22708. doi: 10.1074/jbc.M801765200

PMCID:: PMC2504897

Abstract Article PDF–354K

Select item 122203315.

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.

E Kolobova, A Tuganova, I Boulatnikov, K M Popov

Biochem J. 2001 Aug 15; 358(Pt 1): 69–77. doi: 10.1042/0264-6021:3580069

PMCID:: PMC1222033

Summary PDF–195K

Select item 121903116.

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.

M M Bowker-Kinley, W I Davis, P Wu, R A Harris, K M Popov

Biochem J. 1998 Jan 1; 329(Pt 1): 191–196. doi: 10.1042/bj3290191

PMCID:: PMC1219031

Summary PDF–219K

Select item 13924117.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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