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Select item 108730291.

Catechol-O-Methyltransferase Inhibition and Alcohol Use Disorder: Evaluating the Efficacy of Tolcapone in Ethanol-Dependent Rats

Michelle R. Doyle, Selen Dirik, Angelica R. Martinez, Talyn E. Hughes, Mohini R. Iyer, Elizabeth A. Sneddon, Hyeonglim Seo, Seth M. Cohen, Giordano de Guglielmo

Neuropharmacology. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Neuropharmacology. 2024 Jan 1; 242: 109770. Published online 2023 Oct 17. doi: 10.1016/j.neuropharm.2023.109770

PMCID:: PMC10873029

Abstract Article PDF–1.0M

Select item 107790862.

3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

Thanalai Poonsiri, Davide Dell’Accantera, Valentina Loconte, Alessandro Casnati, Laura Cervoni, Alessandro Arcovito, Stefano Benini, Alberto Ferrari, Marco Cipolloni, Elisa Cacioni, Francesca De Franco, Nicola Giacchè, Serena Rinaldo, Claudia Folli, Francesco Sansone, Rodolfo Berni, Michele Cianci

Int J Mol Sci. 2024 Jan; 25(1): 479. Published online 2023 Dec 29. doi: 10.3390/ijms25010479

PMCID:: PMC10779086

Abstract Article PDF–3.2M

Select item 105724893.

Limiting Monoamines Degradation Increases L-DOPA Pro-Locomotor Action in Newborn Rats

Inès Khsime, Marie Boulain, Abderrahman Fettah, Abdeslam Chagraoui, Gilles Courtand, Philippe De Deurwaerdère, Laurent Juvin, Grégory Barrière

Int J Mol Sci. 2023 Oct; 24(19): 14747. Published online 2023 Sep 29. doi: 10.3390/ijms241914747

PMCID:: PMC10572489

Abstract Article PDF–2.1M

Select item 102706884.

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick

eLife. 2023; 12: e78187. Published online 2023 Jun 6. doi: 10.7554/eLife.78187

PMCID:: PMC10270688

Abstract Article PDF–7.0M

Select item 101312515.

Tolcapone Treatment for Cognitive and Behavioral Symptoms in Behavioral Variant Frontotemporal Dementia: A Placebo-Controlled Crossover Study

Rachel Fremont, Masood Manoochehri, Nicole M. Armstrong, Venkata S. Mattay, Jose A. Apud, Mary C. Tierney, D.P. Devanand, Yunglin Gazes, Christian Habeck, Eric M. Wassermann, Jordan Grafman, Edward D. Huey

J Alzheimers Dis. Author manuscript; available in PMC 2023 Apr 26.

Published in final edited form as: J Alzheimers Dis. 2020; 75(4): 1391–1403. doi: 10.3233/JAD-191265

PMCID:: PMC10131251

Abstract Article PDF–587K

Select item 96614766.

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation

Francisca Pinheiro, Irantzu Pallarès, Francesca Peccati, Adrià Sánchez-Morales, Nathalia Varejão, Filipa Bezerra, David Ortega-Alarcon, Danilo Gonzalez, Marcelo Osorio, Susanna Navarro, Adrián Velázquez-Campoy, Maria Rosário Almeida, David Reverter, Félix Busqué, Ramon Alibés, Mariona Sodupe, Salvador Ventura

J Med Chem. 2022 Nov 10; 65(21): 14673–14691. Published online 2022 Oct 28. doi: 10.1021/acs.jmedchem.2c01195

PMCID:: PMC9661476

Abstract Article PDF–6.1M

Select item 93715267.

Tolcapone improves outcomes in patients with Parkinson disease treated by levodopa/carbidopa intestinal gel: A pilot study

Peter Valkovič, Michal Minár, Peter Matejička, Karin Gmitterová, Veronika Boleková, Zuzana Košutzká

Medicine (Baltimore) 2022 Aug 12; 101(32): e29526. Published online 2022 Aug 12. doi: 10.1097/MD.0000000000029526

PMCID:: PMC9371526

Abstract Article PDF–783K

Select item 92060028.

Cortical dopamine reduces the impact of motivational biases governing automated behaviour

Vanessa Scholz, Roxanne W. Hook, Mojtaba Rostami Kandroodi, Johannes Algermissen, Konstantinos Ioannidis, David Christmas, Stephanie Valle, Trevor W. Robbins, Jon E. Grant, Samuel R. Chamberlain, Hanneke E. M. den Ouden

Neuropsychopharmacology. 2022 Jul; 47(8): 1503–1512. Published online 2022 Mar 8. doi: 10.1038/s41386-022-01291-8

PMCID:: PMC9206002

Abstract Article PDF–1.0M

Select item 91501469.

Catechol-O-methyltransferase activity does not influence emotional processing in men

Marieke AG Martens, Nina Dalton, Jessica Scaife, Catherine J Harmer, Paul J Harrison, Elizabeth M Tunbridge

J Psychopharmacol. 2022 Jun; 36(6): 768–775. Published online 2022 Apr 20. doi: 10.1177/02698811221089032

PMCID:: PMC9150146

Abstract Article PDF–666K

Select item 907350410.

Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone

Joseph P. Schacht, Yeongbin Im, Michaela Hoffman, Konstantin E. Voronin, Sarah W. Book, Raymond F. Anton

Neuropsychopharmacology. 2022 Oct; 47(11): 1953–1960. Published online 2022 May 6. doi: 10.1038/s41386-022-01335-z

PMCID:: PMC9073504

Abstract Article PDF–1.2M

Select item 883003311.

Catechol‐O‐methyltransferase inhibitors for levodopa‐induced complications in Parkinson's disease

Katherine Deane, Sybille Spieker, Carl E Clarke, Cochrane Movement Disorders Group

Cochrane Database Syst Rev. 2004 Oct; 2004(4): CD004554. Published online 2004 Oct 18. doi: 10.1002/14651858.CD004554.pub2

PMCID:: PMC8830033

Abstract Article PDF–460K

Select item 882989712.

Catechol‐O‐methyltransferase inhibitors versus active comparators for levodopa‐induced complications in Parkinson's disease

Katherine Deane, Sybille Spieker, Carl E Clarke, Cochrane Movement Disorders Group

Cochrane Database Syst Rev. 2004 Oct; 2004(4): CD004553. Published online 2004 Oct 18. doi: 10.1002/14651858.CD004553.pub2

PMCID:: PMC8829897

Abstract Article PDF–182K

Select item 864793513.

Augmenting frontal dopamine tone enhances maintenance over gating processes in working memory

Daniella J. Furman, Zhihao Zhang, Christopher H. Chatham, Maxwell Good, David Badre, Ming Hsu, Andrew S. Kayser

J Cogn Neurosci. Author manuscript; available in PMC 2021 Dec 6.

Published in final edited form as: J Cogn Neurosci. 2021 Aug 1; 33(9): 1753–1765. doi: 10.1162/jocn_a_01641

PMCID:: PMC8647935

Abstract Article PDF–428K

Select item 856184214.

Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis

Jan M. Griffin, Hannah Rosenblum, Mathew S. Maurer

Circ Res. Author manuscript; available in PMC 2022 May 14.

Published in final edited form as: Circ Res. 2021 May 14; 128(10): 1554–1575. Published online 2021 May 13. doi: 10.1161/CIRCRESAHA.121.318187

PMCID:: PMC8561842

Abstract Article PDF–1.5M

Select item 819892415.

Virtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phase

Alfredo Juárez-Saldivar, Elizabeth Barbosa-Cabrera, Edgar E. Lara-Ramírez, Alma D. Paz-González, Ana V. Martínez-Vázquez, Virgilio Bocanegra-García, Isidro Palos, Nuria E. Campillo, Gildardo Rivera

Int J Mol Sci. 2021 Jun; 22(11): 5943. Published online 2021 May 31. doi: 10.3390/ijms22115943