Acsl6 acyl-CoA synthetase long-chain family member 6 [Rattus norvegicus (Norway rat)] - Gene - NCBI

An official website of the United States government
Here's how you know

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Log in Show account info

Close
Account

Logged in as:
username

Dashboard

Publications

Account settings

Log out

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Gene

Genes and mapped phenotypes

Search database
All Databases

Assembly

Biocollections

BioProject

BioSample

Books

ClinVar

Conserved Domains

dbGaP

dbVar

Gene

Genome

GEO DataSets

GEO Profiles

GTR

Identical Protein Groups

MedGen

MeSH

NLM Catalog

Nucleotide

OMIM

PMC

PopSet

Protein

Protein Clusters

Protein Family Models

PubChem BioAssay

PubChem Compound

PubChem Substance

PubMed

SNP

SRA

Structure

Taxonomy

ToolKit

ToolKitAll

ToolKitBookgh

Search term

Search

Advanced

Help

Result Filters

Gene sources
Clear

Genomic

Categories
Clear

Alternatively spliced

Annotated genes

Protein-coding

Sequence content
Clear

Ensembl

RefSeq

Status
Clear

Current(1)

Chromosome locations
Clear

more...
x
Chromosome locations
Select an organism by typing or scrolling

Chromosome

From

To

Apply

Clear all

Show additional filters

x
Additional filters

Gene sources

Categories

Sequence content

Status

Chromosome locations

Search fields

Show

S I D E B A R

Full Report

Format

Full Report

Full Report (text)

Expression

Gene Table

Gene Table (text)

GeneRIF

Summary

Summary (text)

Tabular

Tabular (text)

ASN.1

XML

UI List

Apply
Send to:

Choose Destination

File

Clipboard

Collections

Format
Full Report (text)

Gene Table (text)

Summary (text)

Tabular (text)

ASN.1

XML

UI List

Create File

Add to Clipboard

Add to Collections

Links from GEO Profiles

Showing Current items.

Acsl6 acyl-CoA synthetase long-chain family member 6 [ Rattus norvegicus (Norway rat) ]
Gene ID: 117243, updated on 9-Dec-2024

Download Datasets

Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

File name
Download

Summary

Go to the top of the page Help

Official Symbol

Acsl6provided by RGD

Official Full Name

acyl-CoA synthetase long-chain family member 6provided by RGD

Primary source

RGD:69403

See related

EnsemblRapid:ENSRNOG00000026745 AllianceGenome:RGD:69403

Gene type

protein coding

RefSeq status

PROVISIONAL

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

Facl6; Lacsl

Summary

Enables arachidonate-CoA ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrial outer membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Brain (RPKM 283.1), Muscle (RPKM 230.5) and 3 other tissues See more

Orthologs

human mouse all

NEW

Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See Acsl6 in Genome Data Viewer

Location:

10q22

Exon count:

25

Items 1 - 3 of 3

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 10 | NC_086028.1 (38940668..38999515)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 10 | NC_051345.1 (38439914..38501182)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 10 | NC_005109.4 (39654771..39717592)

Items 1 - 3 of 3

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Chromosome 10 - NC_086028.1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:
NC_086028.1 Chromosome 10 Reference GRCr8

NC_051345.1 Chromosome 10 Reference mRatBN7.2 Primary Assembly

NC_005109.4 Chromosome 10 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

Related articles in PubMed

1. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. Marszalek JR, et al. J Biol Chem, 2005 Mar 18. PMID 15655248

2. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn CG, et al. Biochemistry, 2005 Feb 8. PMID 15683247

3. Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain. Fujino T, et al. J Biochem, 1992 Feb. PMID 1569043

4. Transient maintenance in bioreactor improves health of neuronal cells. Di Loreto S, et al. In Vitro Cell Dev Biol Anim, 2006 May-Jun. PMID 16848632

5. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Dillon JS, et al. Diabetes, 2000 Dec. PMID 11118002

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
Title: Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.

2. ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation
Title: Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.

3. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
Title: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.

4. Acsl6 functions primarily in DHA metabolism, and its overexpression increases DHA and AA internalization primarily during the first 24 h of neuronal differentiation to stimulate phospholipid synthesis and enhance neurite outgrowth
Title: Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism.

5. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Acsl6 (e-PCR), detects polymorphism

UniSTS:502706

Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

Items 1 - 10 of 10

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Function | Evidence Code | Pubs

enables ATP binding

IEA
Inferred from Electronic Annotation
more info

enables arachidonate-CoA ligase activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables arachidonate-CoA ligase activity

IDA
Inferred from Direct Assay
more info

PubMed

enables enzyme binding

ISO
Inferred from Sequence Orthology
more info

enables long-chain fatty acid-CoA ligase activity

IDA
Inferred from Direct Assay
more info

PubMed

enables long-chain fatty acid-CoA ligase activity

IEA
Inferred from Electronic Annotation
more info

enables long-chain fatty acid-CoA ligase activity

ISO
Inferred from Sequence Orthology
more info

enables protein homodimerization activity

IDA
Inferred from Direct Assay
more info

PubMed

enables protein homodimerization activity

IEA
Inferred from Electronic Annotation
more info

enables protein homodimerization activity

ISO
Inferred from Sequence Orthology
more info

Items 1 - 10 of 10

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Items 1 - 21 of 21

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Process | Evidence Code | Pubs

involved_in cellular response to insulin stimulus

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in fatty acid transport

IGI
Inferred from Genetic Interaction
more info

PubMed

involved_in lipid biosynthetic process

IEA
Inferred from Electronic Annotation
more info

involved_in long-chain fatty acid metabolic process

IBA
Inferred from Biological aspect of Ancestor
more info

involved_in long-chain fatty acid metabolic process

IDA
Inferred from Direct Assay
more info

PubMed

involved_in long-chain fatty acid metabolic process

IEA
Inferred from Electronic Annotation
more info

involved_in long-chain fatty acid metabolic process

ISO
Inferred from Sequence Orthology
more info

involved_in long-chain fatty-acyl-CoA biosynthetic process

IBA
Inferred from Biological aspect of Ancestor
more info

involved_in long-chain fatty-acyl-CoA biosynthetic process

IGI
Inferred from Genetic Interaction
more info

PubMed

involved_in neuroblast proliferation

IEA
Inferred from Electronic Annotation
more info

acts_upstream_of_or_within neuroblast proliferation

ISO
Inferred from Sequence Orthology
more info

involved_in neuron development

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in phospholipid biosynthetic process

IMP
Inferred from Mutant Phenotype
more info

PubMed

involved_in positive regulation of long-chain fatty acid import across plasma membrane

IMP
Inferred from Mutant Phenotype
more info

PubMed

involved_in positive regulation of neuron projection development

IMP
Inferred from Mutant Phenotype
more info

PubMed

involved_in response to gravity

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in response to hypoxia

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in response to nutrient

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in response to steroid hormone

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in triglyceride biosynthetic process

IGI
Inferred from Genetic Interaction
more info

PubMed

involved_in very long-chain fatty acid metabolic process

IBA
Inferred from Biological aspect of Ancestor
more info

Items 1 - 21 of 21

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Items 1 - 8 of 8

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Component | Evidence Code | Pubs

is_active_in endoplasmic reticulum

IBA
Inferred from Biological aspect of Ancestor
more info

located_in endoplasmic reticulum

ISO
Inferred from Sequence Orthology
more info

located_in endoplasmic reticulum

ISS
Inferred from Sequence or Structural Similarity
more info

located_in endoplasmic reticulum membrane

IEA
Inferred from Electronic Annotation
more info

is_active_in membrane

IBA
Inferred from Biological aspect of Ancestor
more info

located_in membrane

ISO
Inferred from Sequence Orthology
more info

located_in mitochondrial outer membrane

IEA
Inferred from Electronic Annotation
more info

located_in peroxisomal membrane

IEA
Inferred from Electronic Annotation
more info

Items 1 - 8 of 8

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

General protein information

Go to the top of the page Help

Preferred Names

long-chain-fatty-acid--CoA ligase 6

Names

LACS 6

arachidonate--CoA ligase

fatty acid Coenzyme A ligase, long chain 6

long-chain acyl-CoA synthetase 6

long-chain-fatty-acid--CoA ligase, brain isozyme

NP_570095.2

EC 6.2.1.15

EC 6.2.1.3

XP_006246283.3

EC 6.2.1.15

EC 6.2.1.3

XP_006246284.3

EC 6.2.1.15

EC 6.2.1.3

XP_006246286.1

EC 6.2.1.15

EC 6.2.1.3

XP_038941005.2

EC 6.2.1.15

EC 6.2.1.3

XP_063124393.1

EC 6.2.1.15

EC 6.2.1.3

XP_063124394.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_130739.2 → NP_570095.2 long-chain-fatty-acid--CoA ligase 6

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P33124, Q63835, Q6IU14

UniProtKB/TrEMBL

A0A0A6YYM0, A6HEH5

Related

ENSRNOP00000033248.6, ENSRNOT00000030760.6

Conserved Domains (1) summary

cd05927
Location:116 → 694

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086028.1 Reference GRCr8

Range

38940668..38999515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_006246224.5 → XP_006246286.1 long-chain-fatty-acid--CoA ligase 6 isoform X4

See identical proteins and their annotated locations for XP_006246286.1

UniProtKB/TrEMBL

A0A8I5ZSH7

Related

ENSRNOP00000081838.1, ENSRNOT00000115137.2

Conserved Domains (2) summary

PLN02736
Location:79 → 694

PLN02736; long-chain acyl-CoA synthetase

cd05927
Location:116 → 693

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

2. XM_006246221.5 → XP_006246283.3 long-chain-fatty-acid--CoA ligase 6 isoform X2

UniProtKB/TrEMBL

A0A0A6YYM0, A0A8I6B3S2

Related

ENSRNOP00000096136.1, ENSRNOT00000103397.2

3. XM_006246222.5 → XP_006246284.3 long-chain-fatty-acid--CoA ligase 6 isoform X1

UniProtKB/TrEMBL

A0A0A6YYM0

Related

ENSRNOP00000055608.6, ENSRNOT00000058817.7

4. XM_063268324.1 → XP_063124394.1 long-chain-fatty-acid--CoA ligase 6 isoform X6

UniProtKB/TrEMBL

A0A0A6YYM0

5. XM_039085077.2 → XP_038941005.2 long-chain-fatty-acid--CoA ligase 6 isoform X3

UniProtKB/TrEMBL

A0A0A6YYM0

6. XM_063268323.1 → XP_063124393.1 long-chain-fatty-acid--CoA ligase 6 isoform X5

Related sequences

Go to the top of the page Help

Items 1 - 9 of 9

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH473948.1 | EDM04428.1
| EDM04429.1
| EDM04430.1
| EDM04431.1
genomic | HB881417.1 | CBF64987.1
genomic | HC938826.1 | CBU89858.1
genomic | JAXUCZ010000010.1 (38940668..38999515) | None | BN/NHsdMcwi
mRNA | AY625254.1 | AAT41589.1 | Sprague-Dawley
mRNA | D10041.1 | BAA00932.1 | W/Slc
mRNA | EF490998.1 | ABS32032.1
mRNA | FQ213651.1 | None | Sprague-Dawley
mRNA | S56508.1 | AAB19809.2

Items 1 - 9 of 9

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Items 1 - 1 of 1

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Protein Accession | Links
GenPept Link | UniProtKB Link
P33124.1 | GenPept | UniProtKB/Swiss-Prot:P33124

Items 1 - 1 of 1

<< First << First < Prev < Prev Page of 1 Next > Next > Last >> Last >>

Additional links

Go to the top of the page Help

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

Interologous Interaction Database

Interologous Interaction Database

MilliporeSigma

Acsl6 products

Molecular Biology Databases

Bgee database

Acsl6 gene expression

BioGPS

BioGPS

CTD: Comparative Toxicogenomics Database

CTD: Comparative Toxicogenomics Database - ACSL6

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order Acsl6 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

Miscellaneous

Reactome

Reactome Entity:P33124

Reactome Event:Metabolism

Hide sidebar >>

Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

Pathways from PubChem

General gene information
Markers, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

Loading...

Related information

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

RGD

EnsemblRapid

AllianceGenome

UCSC

KEGG

Reactome

General information

About Gene

FAQ

FTP site

Help

My NCBI help

NCBI Handbook

Statistics

Related sites

BLAST

Genome

BioProject

Genome Data Viewer

GEO

OMIM

Probe

RefSeq

Feedback

Contact Help Desk

Submit Correction

Submit GeneRIF

Subscription

RefSeq

Recent activity

Clear Turn Off Turn On

Acsl6 acyl-CoA synthetase long-chain family member 6 [Rattus norvegicus]
Acsl6 acyl-CoA synthetase long-chain family member 6 [Rattus norvegicus]
Gene ID:117243

Gene

Gene Links for GEO Profiles (Select 25926831) (1)
Gene

Drosophila melanogaster RE30427 full length cDNA
Drosophila melanogaster RE30427 full length cDNA
gi|17945690|gb|AY071273.1|

Nucleotide

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on
See more...

Follow NCBI

Connect with NLM

National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894

Web Policies
FOIA
HHS Vulnerability Disclosure

Help
Accessibility
Careers

NLM

NIH

HHS

USA.gov

PreferencesTurn off

Loading

External link. Please review our privacy policy.