Bmp5 bone morphogenetic protein 5 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Bmp5 bone morphogenetic protein 5 [ Rattus norvegicus (Norway rat) ]
Gene ID: 315824, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

File name
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Summary

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Official Symbol

Bmp5provided by RGD

Official Full Name

bone morphogenetic protein 5provided by RGD

Primary source

RGD:1305979

See related

EnsemblRapid:ENSRNOG00000010917 AllianceGenome:RGD:1305979

Gene type

protein coding

RefSeq status

PROVISIONAL

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Summary

Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including chordate embryonic development; heart development; and negative regulation of steroid hormone biosynthetic process. Predicted to act upstream of or within several processes, including anterior head development; ear development; and male genitalia development. Located in extracellular space and vesicle. Orthologous to human BMP5 (bone morphogenetic protein 5). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Liver (RPKM 42.9), Lung (RPKM 37.4) and 6 other tissues See more

Orthologs

human mouse all

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Try the new Transcript table

Genomic context

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See Bmp5 in Genome Data Viewer

Location:

8q24

Exon count:

7

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 8 | NC_086026.1 (85397629..85520374)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 8 | NC_051343.1 (76517164..76639925)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 8 | NC_005107.4 (82669466..82950273)

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Chromosome 8 - NC_086026.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086026.1 Chromosome 8 Reference GRCr8

NC_051343.1 Chromosome 8 Reference mRatBN7.2 Primary Assembly

NC_005107.4 Chromosome 8 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. BMP5 expression in the adult rat brain. Kusakawa Y, et al. Neuroscience, 2015 Jan 22. PMID 25110111

2. BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures. Mailhot G, et al. J Cell Physiol, 2008 Jan. PMID 17541940, Free PMC Article

3. Bone morphogenetic protein 5 expression in the rat ovary: biological effects on granulosa cell proliferation and steroidogenesis. Pierre A, et al. Biol Reprod, 2005 Dec. PMID 16079308

4. Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis. Johnsen IK, et al. Cancer Res, 2009 Jul 15. PMID 19584291

5. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Kingsley DM, et al. Cell, 1992 Oct 30. PMID 1339316

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Results suggest that BMP5 is widely expressed throughout the adult CNS, and this abundant expression in the adult brain strongly supports the idea that BMP5 plays important roles not only in the developing brain but also in the adult brain
Title: BMP5 expression in the adult rat brain.

2. Bmp5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes cartilage matrix synthesis in primary chondrocyte cultures.
Title: BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures.

3. BMP5 might play a fully paracrine role in rodent ovarian folliculogenesis.
Title: Bone morphogenetic protein 5 expression in the rat ovary: biological effects on granulosa cell proliferation and steroidogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:496642 (e-PCR)

UniSTS:496642

Bmp5 (e-PCR), detects polymorphism

UniSTS:496642

26.MMHAP76FRA11.seq (e-PCR)

UniSTS:123754

PMC56999P1 (e-PCR)

UniSTS:273363

Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

enables BMP receptor binding

ISO
Inferred from Sequence Orthology
more info

enables cytokine activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables growth factor activity

IEA
Inferred from Electronic Annotation
more info

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Process | Evidence Code | Pubs

involved_in BMP signaling pathway

ISO
Inferred from Sequence Orthology
more info

involved_in allantois development

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within anterior head development

ISO
Inferred from Sequence Orthology
more info

involved_in cardiac muscle tissue development

ISO
Inferred from Sequence Orthology
more info

involved_in cardiac septum morphogenesis

ISO
Inferred from Sequence Orthology
more info

involved_in chorio-allantoic fusion

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within ear development

ISO
Inferred from Sequence Orthology
more info

involved_in endocardial cushion formation

ISO
Inferred from Sequence Orthology
more info

involved_in heart trabecula morphogenesis

ISO
Inferred from Sequence Orthology
more info

involved_in hindbrain development

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within male genitalia development

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of aldosterone biosynthetic process

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of cell population proliferation

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of cortisol biosynthetic process

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of insulin-like growth factor receptor signaling pathway

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of steroid biosynthetic process

ISO
Inferred from Sequence Orthology
more info

involved_in neural fold elevation formation

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within pattern specification process

ISO
Inferred from Sequence Orthology
more info

involved_in pericardium morphogenesis

ISO
Inferred from Sequence Orthology
more info

involved_in pharyngeal system development

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of SMAD protein signal transduction

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of cell population proliferation

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of dendrite development

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of epithelial cell proliferation

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of transcription by RNA polymerase II

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within skeletal system development

ISO
Inferred from Sequence Orthology
more info

involved_in type B pancreatic cell development

ISO
Inferred from Sequence Orthology
more info

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Component | Evidence Code | Pubs

is_active_in extracellular space

IBA
Inferred from Biological aspect of Ancestor
more info

located_in extracellular space

IDA
Inferred from Direct Assay
more info

PubMed

located_in vesicle

IDA
Inferred from Direct Assay
more info

PubMed

Items 1 - 3 of 3

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General protein information

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Preferred Names

bone morphogenetic protein 5

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001108168.1 → NP_001101638.1 bone morphogenetic protein 5 precursor

See identical proteins and their annotated locations for NP_001101638.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I1F0, D4A7P9

Related

ENSRNOP00000014846.5, ENSRNOT00000014846.7

Conserved Domains (2) summary

smart00204
Location:353 → 454

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:31 → 304

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086026.1 Reference GRCr8

Range

85397629..85520374

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH473954.2 | EDL77777.1
genomic | JAXUCZ010000008.1 (85397629..85520374) | None | BN/NHsdMcwi

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

MilliporeSigma

Bmp5 products

Molecular Biology Databases

Bgee database

Bmp5 gene expression

BioGPS

BioGPS

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order Bmp5 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

General gene information
Markers, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

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EnsemblRapid

AllianceGenome

UCSC

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Gene

Bmp5 bone morphogenetic protein 5 [Rattus norvegicus]
Bmp5 bone morphogenetic protein 5 [Rattus norvegicus]
Gene ID:315824

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