Dux4 double homeobox 4 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Dux4 double homeobox 4 [ Rattus norvegicus (Norway rat) ]
Gene ID: 306226, updated on 9-Dec-2024

Download Datasets

Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

File name
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Summary

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Official Symbol

Dux4provided by RGD

Official Full Name

double homeobox 4provided by RGD

Primary source

RGD:1311053

See related

EnsemblRapid:ENSRNOG00000025408 AllianceGenome:RGD:1311053

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

Duxbl; Duxbl1; RGD1311053

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of G0 to G1 transition; negative regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of T cell differentiation. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be active in nucleus. Orthologous to several human genes including DUXB (double homeobox B). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Lung (RPKM 33.0), Uterus (RPKM 15.8) and 9 other tissues See more

Orthologs

human all

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Genomic context

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See Dux4 in Genome Data Viewer

Location:

16p16

Exon count:

6

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 16 | NC_086034.1 (1565290..1575317)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 16 | NC_051351.1 (1558430..1570045)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 16 | NC_005115.4 (3754968..3766532, complement)

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Chromosome 16 - NC_086034.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086034.1 Chromosome 16 Reference GRCr8

NC_051351.1 Chromosome 16 Reference mRatBN7.2 Primary Assembly

NC_005115.4 Chromosome 16 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. Structural basis for multiple gene regulation by human DUX4. Li Y, et al. Biochem Biophys Res Commun, 2018 Nov 10. PMID 30322619

2. DUX4(HD2)-DNA(ERG) structure reveals new insight into DUX4-Responsive-Element. Dong X, et al. Leukemia, 2019 Feb. PMID 30315230, Free PMC Article

3. Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression. Xu H, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24589735

4. The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. Kowaljow V, et al. Neuromuscul Disord, 2007 Aug. PMID 17588759

5. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Dixit M, et al. Proc Natl Acad Sci U S A, 2007 Nov 13. PMID 17984056, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

Items 1 - 6 of 6

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Function | Evidence Code | Pubs

enables DNA-binding transcription activator activity, RNA polymerase II-specific

ISO
Inferred from Sequence Orthology
more info

enables DNA-binding transcription factor activity, RNA polymerase II-specific

IBA
Inferred from Biological aspect of Ancestor
more info

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

ISO
Inferred from Sequence Orthology
more info

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

IBA
Inferred from Biological aspect of Ancestor
more info

enables sequence-specific double-stranded DNA binding

ISO
Inferred from Sequence Orthology
more info

enables transcription cis-regulatory region binding

ISO
Inferred from Sequence Orthology
more info

Items 1 - 6 of 6

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Items 1 - 6 of 6

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Process | Evidence Code | Pubs

involved_in apoptotic process

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of G0 to G1 transition

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of cell population proliferation

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of transcription by RNA polymerase II

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within regulation of T cell differentiation

ISO
Inferred from Sequence Orthology
more info

involved_in regulation of transcription by RNA polymerase II

IBA
Inferred from Biological aspect of Ancestor
more info

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Items 1 - 8 of 8

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Component | Evidence Code | Pubs

located_in Golgi apparatus

ISO
Inferred from Sequence Orthology
more info

located_in cytoplasm

ISO
Inferred from Sequence Orthology
more info

located_in cytosol

ISO
Inferred from Sequence Orthology
more info

located_in nuclear membrane

ISO
Inferred from Sequence Orthology
more info

located_in nucleolus

ISO
Inferred from Sequence Orthology
more info

located_in nucleoplasm

ISO
Inferred from Sequence Orthology
more info

is_active_in nucleus

IBA
Inferred from Biological aspect of Ancestor
more info

located_in nucleus

ISO
Inferred from Sequence Orthology
more info

Items 1 - 8 of 8

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General protein information

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Preferred Names

double homeobox 4; double homeobox protein B

Names

double homeobox B-like 1

double homeobox protein 4C-like

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001433002.1 → NP_001419931.1 double homeobox 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D3ZTT0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086034.1 Reference GRCr8

Range

1565290..1575317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_063275801.1 → XP_063131871.1 double homeobox protein B

UniProtKB/TrEMBL

D3ZTT0

Related

ENSRNOP00000044374.4, ENSRNOT00000052224.7

2. XM_063275802.1 → XP_063131872.1 double homeobox protein B

UniProtKB/TrEMBL

D3ZTT0

Related sequences

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Items 1 - 2 of 2

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH474067.2 | EDL75080.1
| EDL75081.1
genomic | JAXUCZ010000016.1 (1565290..1575317) | None | BN/NHsdMcwi

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

MilliporeSigma

DUX4 products

Molecular Biology Databases

BioGPS

BioGPS

CTD: Comparative Toxicogenomics Database

CTD: Comparative Toxicogenomics Database - DUX4

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

OriGene

Order Duxbl1 cDNA clone/Protein/Antibody/RNAi

Order DUX4 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

General gene information
Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

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Dux4 double homeobox 4 [Rattus norvegicus]
Dux4 double homeobox 4 [Rattus norvegicus]
Gene ID:306226

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