Map3k20 mitogen-activated protein kinase kinase kinase 20 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Map3k20 mitogen-activated protein kinase kinase kinase 20 [ Rattus norvegicus (Norway rat) ]
Gene ID: 311743, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Official Symbol

Map3k20provided by RGD

Official Full Name

mitogen-activated protein kinase kinase kinase 20provided by RGD

Primary source

RGD:1561394

See related

EnsemblRapid:ENSRNOG00000001515 AllianceGenome:RGD:1561394

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

Zak; MLTK; RGD1561394

Summary

Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to radiation; intracellular signal transduction; and regulation of cellular response to stress. Predicted to act upstream of with a positive effect on pyroptotic inflammatory response. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Muscle (RPKM 261.3), Heart (RPKM 159.0) and 8 other tissues See more

Orthologs

human mouse all

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Genomic context

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See Map3k20 in Genome Data Viewer

Location:

3q23

Exon count:

21

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 3 | NC_086021.1 (77538146..77697540)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 3 | NC_051338.1 (57130539..57289943)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 3 | NC_005102.4 (58965025..59120507)

Items 1 - 3 of 3

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Chromosome 3 - NC_086021.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086021.1 Chromosome 3 Reference GRCr8

NC_051338.1 Chromosome 3 Reference mRatBN7.2 Primary Assembly

NC_005102.4 Chromosome 3 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation. Hsieh YL, et al. Mol Cell Biochem, 2015 Jul. PMID 25869677

2. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Liu TC, et al. Biochem Biophys Res Commun, 2000 Aug 11. PMID 10924358

3. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. Gotoh I, et al. J Biol Chem, 2001 Feb 9. PMID 11042189

4. The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. Tosti E, et al. J Biol Chem, 2004 Nov 12. PMID 15342622

5. ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells. Cheng YC, et al. Mol Cell Biochem, 2009 May. PMID 19184368

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. The role of ZAK and/or the ZAK downstream events such as JNK and p38 phosphorylation, c-Jun, and GATA-4 nuclear translocation in cardiac hypertrophy.
Title: ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation.

2. ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression.
Title: ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

RH134323 (e-PCR)

UniSTS:217605

BG374587 (e-PCR)

UniSTS:249687

BE097452 (e-PCR)

UniSTS:244668

RH80553 (e-PCR)

UniSTS:88774

Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

enables ATP binding

ISO
Inferred from Sequence Orthology
more info

enables JUN kinase kinase kinase activity

ISO
Inferred from Sequence Orthology
more info

enables JUN kinase kinase kinase activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables MAP kinase kinase kinase activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables MAP kinase kinase kinase activity

ISO
Inferred from Sequence Orthology
more info

enables MAP kinase kinase kinase activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables magnesium ion binding

ISO
Inferred from Sequence Orthology
more info

enables protein kinase activator activity

ISO
Inferred from Sequence Orthology
more info

enables protein kinase activator activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables protein kinase regulator activity

ISO
Inferred from Sequence Orthology
more info

enables protein serine/threonine kinase activity

ISO
Inferred from Sequence Orthology
more info

enables protein serine/threonine kinase activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables ribosome binding

ISO
Inferred from Sequence Orthology
more info

enables ribosome binding

ISS
Inferred from Sequence or Structural Similarity
more info

enables small ribosomal subunit rRNA binding

ISO
Inferred from Sequence Orthology
more info

enables small ribosomal subunit rRNA binding

ISS
Inferred from Sequence or Structural Similarity
more info

enables stalled ribosome sensor activity

ISO
Inferred from Sequence Orthology
more info

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Items 1 - 25 of 31

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Process | Evidence Code | Pubs

involved_in DNA damage checkpoint signaling

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of GCN2-mediated signaling

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of GCN2-mediated signaling

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in JNK cascade

ISO
Inferred from Sequence Orthology
more info

involved_in JNK cascade

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in MAPK cascade

ISO
Inferred from Sequence Orthology
more info

involved_in cellular response to UV-B

ISO
Inferred from Sequence Orthology
more info

involved_in cellular response to UV-B

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in cellular response to gamma radiation

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_or_within cytoskeleton organization

ISO
Inferred from Sequence Orthology
more info

involved_in embryonic digit morphogenesis

ISO
Inferred from Sequence Orthology
more info

involved_in inflammatory response

ISO
Inferred from Sequence Orthology
more info

involved_in intracellular signal transduction

ISO
Inferred from Sequence Orthology
more info

involved_in limb development

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of stress-activated protein kinase signaling cascade

ISO
Inferred from Sequence Orthology
more info

involved_in negative regulation of translation in response to endoplasmic reticulum stress

ISO
Inferred from Sequence Orthology
more info

involved_in p38MAPK cascade

ISO
Inferred from Sequence Orthology
more info

involved_in p38MAPK cascade

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in positive regulation of apoptotic process

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of mitotic DNA damage checkpoint

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of positive regulation of programmed cell death

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of positive regulation of programmed cell death

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in protein autophosphorylation

ISO
Inferred from Sequence Orthology
more info

involved_in protein autophosphorylation

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in protein phosphorylation

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_positive_effect pyroptotic inflammatory response

ISO
Inferred from Sequence Orthology
more info

acts_upstream_of_positive_effect pyroptotic inflammatory response

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in signal transduction

IBA
Inferred from Biological aspect of Ancestor
more info

involved_in stress-activated MAPK cascade

ISO
Inferred from Sequence Orthology
more info

involved_in stress-activated MAPK cascade

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in stress-activated protein kinase signaling cascade

ISO
Inferred from Sequence Orthology
more info

Items 1 - 25 of 31

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Items 1 - 6 of 6

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Component | Evidence Code | Pubs

is_active_in cytoplasm

IBA
Inferred from Biological aspect of Ancestor
more info

is_active_in cytoplasm

ISO
Inferred from Sequence Orthology
more info

located_in cytoplasm

ISO
Inferred from Sequence Orthology
more info

located_in cytosol

IEA
Inferred from Electronic Annotation
more info

located_in cytosol

ISO
Inferred from Sequence Orthology
more info

located_in nucleus

ISO
Inferred from Sequence Orthology
more info

Items 1 - 6 of 6

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General protein information

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Preferred Names

mitogen-activated protein kinase kinase kinase 20

Names

mitogen-activated protein kinase kinase kinase MLT

sterile alpha motif and leucine zipper containing kinase AZK

NP_001385922.1

EC 2.7.11.25

NP_001385923.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001398993.1 → NP_001385922.1 mitogen-activated protein kinase kinase kinase 20 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4AE17

Related

ENSRNOP00000002068.3, ENSRNOT00000002068.7

Conserved Domains (2) summary

cd09529
Location:338 → 408

SAM_MLTK; SAM domain of MLTK subfamily

cd14060
Location:22 → 263

STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase

2. NM_001398994.1 → NP_001385923.1 mitogen-activated protein kinase kinase kinase 20 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5Y262, A0A8I6A4W9

Related

ENSRNOP00000077905.1, ENSRNOT00000112816.2

Conserved Domains (1) summary

cd14060
Location:22 → 263

STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086021.1 Reference GRCr8

Range

77538146..77697540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | JAXUCZ010000003.1 (77538146..77697540) | None | BN/NHsdMcwi
mRNA | FQ209892.1 | None | Sprague-Dawley

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases

Bgee database

Map3k20 gene expression

BioGPS

BioGPS

CTD: Comparative Toxicogenomics Database

CTD: Comparative Toxicogenomics Database - MAP3K20

Guide to Pharmacology

ZAK sterile alpha motif and leucine zipper containing kinase AZK gene

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

OriGene

Order ZAK cDNA clone/Protein/Antibody/RNAi

Order Map3k20 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

Pathways from PubChem

General gene information
Markers, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

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UCSC

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Map3k20 mitogen-activated protein kinase kinase kinase 20 [Rattus norvegicus]
Map3k20 mitogen-activated protein kinase kinase kinase 20 [Rattus norvegicus]
Gene ID:311743

Gene

Gene Links for GEO Profiles (Select 22203523) (1)
Gene

Heart left ventricle and diaphragm comparison
Heart left ventricle and diaphragm comparison
Accession: GDS3224

GEO DataSets

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