Pcca propionyl-CoA carboxylase subunit alpha [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Pcca propionyl-CoA carboxylase subunit alpha [ Rattus norvegicus (Norway rat) ]
Gene ID: 687008, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Official Symbol

Pccaprovided by RGD

Official Full Name

propionyl-CoA carboxylase subunit alphaprovided by RGD

Primary source

RGD:3264

See related

EnsemblRapid:ENSRNOG00000057042 AllianceGenome:RGD:3264

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Summary

Predicted to enable enzyme binding activity and propionyl-CoA carboxylase activity. Predicted to be involved in amino acid catabolic process and fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of catalytic complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Heart (RPKM 172.1), Kidney (RPKM 153.2) and 9 other tissues See more

Orthologs

human mouse all

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Genomic context

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See Pcca in Genome Data Viewer

Location:

15q25

Exon count:

24

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 15 | NC_086033.1 (106034586..106374908)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 15 | NC_051350.1 (99627955..99969555)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 15 | NC_005114.4 (108960509..109306879)

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Chromosome 15 - NC_086033.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086033.1 Chromosome 15 Reference GRCr8

NC_051350.1 Chromosome 15 Reference mRatBN7.2 Primary Assembly

NC_005114.4 Chromosome 15 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. Sequence analysis, biogenesis, and mitochondrial import of the alpha-subunit of rat liver propionyl-CoA carboxylase. Browner MF, et al. J Biol Chem, 1989 Jul 25. PMID 2745462

2. Three novel splice mutations in the PCCA gene causing identical exon skipping in propionic acidemia patients. Richard E, et al. Hum Genet, 1997 Nov. PMID 9385377

3. Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain. Ballhausen D, et al. Neuroscience, 2009 Dec 1. PMID 19699272

4. Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts. Stankovics J, et al. Am J Hum Genet, 1993 Jan. PMID 8434582, Free PMC Article

5. Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase and its rescue by postnatal, liver-specific supplementation via a transgene. Miyazaki T, et al. J Biol Chem, 2001 Sep 21. PMID 11461925

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Methylmalonyl-CoA mutase and PCCA show a much higher expression level in the entire CNS than in the liver, suggesting a different, but important function of this pathway during brain development.
Title: Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products | Interactant | Other Gene | Complex | Source | Pubs | Description
BioGRID:601858 | BioGRID:246562 | Gja1 | | BioGRID | PubMed | Affinity Capture-MS
BioGRID:601858 | BioGRID:204969 | Mapk14 | | BioGRID | PubMed | Proximity Label-MS

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General gene information

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Markers

D15Got102 (e-PCR)

UniSTS:113486

Pcca (e-PCR), detects polymorphism

UniSTS:527476

D15Rat63 (e-PCR)

UniSTS:118412

RH94721 (e-PCR)

UniSTS:119968

RH144434 (e-PCR)

UniSTS:233679

BE107713 (e-PCR)

UniSTS:247019

Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

enables ATP binding

IEA
Inferred from Electronic Annotation
more info

enables enzyme binding

IEA
Inferred from Electronic Annotation
more info

enables enzyme binding

ISO
Inferred from Sequence Orthology
more info

enables ligase activity

IEA
Inferred from Electronic Annotation
more info

enables metal ion binding

IEA
Inferred from Electronic Annotation
more info

enables propionyl-CoA carboxylase activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables propionyl-CoA carboxylase activity

IEA
Inferred from Electronic Annotation
more info

enables propionyl-CoA carboxylase activity

ISO
Inferred from Sequence Orthology
more info

enables propionyl-CoA carboxylase activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables propionyl-CoA carboxylase activity

TAS
Traceable Author Statement
more info

PubMed

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Process | Evidence Code | Pubs

involved_in amino acid catabolic process

TAS
Traceable Author Statement
more info

PubMed

involved_in carboxylic acid metabolic process

IEA
Inferred from Electronic Annotation
more info

involved_in fatty acid catabolic process

TAS
Traceable Author Statement
more info

PubMed

involved_in lipid catabolic process

IEA
Inferred from Electronic Annotation
more info

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Component | Evidence Code | Pubs

part_of catalytic complex

IEA
Inferred from Electronic Annotation
more info

part_of catalytic complex

ISO
Inferred from Sequence Orthology
more info

located_in mitochondrial matrix

IEA
Inferred from Electronic Annotation
more info

located_in mitochondrial matrix

ISO
Inferred from Sequence Orthology
more info

located_in mitochondrial matrix

ISS
Inferred from Sequence or Structural Similarity
more info

is_active_in mitochondrion

IBA
Inferred from Biological aspect of Ancestor
more info

located_in mitochondrion

ISO
Inferred from Sequence Orthology
more info

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General protein information

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Preferred Names

propionyl-CoA carboxylase alpha chain, mitochondrial

Names

PCCase alpha subunit

PCCase subunit alpha

Propionyl Coenzyme A carboxylase alpha polypeptide

propanoyl-CoA:carbon dioxide ligase alpha subunit

propanoyl-CoA:carbon dioxide ligase subunit alpha

propionyl CoA carboxylase, alpha polypeptide

propionyl-CoA carboxylase alpha subunit

propionyl-coenzyme A carboxylase, alpha polypeptide

NP_062203.2

EC 6.4.1.3

XP_038949592.1

EC 6.4.1.3

XP_063130717.1

EC 6.4.1.3

XP_063130718.1

EC 6.4.1.3

XP_063130719.1

EC 6.4.1.3

XP_063130720.1

EC 6.4.1.3

XP_063130721.1

EC 6.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_019330.2 → NP_062203.2 propionyl-CoA carboxylase alpha chain, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5ZL37, A6HUM3

Related

ENSRNOP00000076923.2, ENSRNOT00000097463.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086033.1 Reference GRCr8

Range

106034586..106374908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_063274647.1 → XP_063130717.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZL37, A0A8I5ZVD4

2. XM_063274648.1 → XP_063130718.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A0G2K5P9

3. XM_063274649.1 → XP_063130719.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A0G2K401, A6HUM4

Related

ENSRNOP00000072844.2, ENSRNOT00000077482.3

4. XM_063274650.1 → XP_063130720.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I5ZL37

5. XM_039093664.2 → XP_038949592.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8I5ZL37, A0A8I5ZWE0

Related

ENSRNOP00000082095.1, ENSRNOT00000094922.2

Conserved Domains (1) summary

cl39082
Location:58 → 667

PycA; Pyruvate carboxylase [Energy production and conversion]

6. XM_063274651.1 → XP_063130721.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X6

UniProtKB/TrEMBL

A0A8I5YBZ6

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | AC123185.5 | None
genomic | JAXUCZ010000015.1 (106034586..106374908) | None | BN/NHsdMcwi
mRNA | BQ191052.1 | None | Sprague-Dawley
mRNA | CK228512.1 | None | Sprague-Dawley
mRNA | CK601565.1 | None
mRNA | CO574538.1 | None
mRNA | CX570803.1 | None

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Protein Accession | Links
GenPept Link | UniProtKB Link
P14882.3 | GenPept | UniProtKB/Swiss-Prot:P14882

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

Interologous Interaction Database

Interologous Interaction Database

MilliporeSigma

PCCA products

Molecular Biology Databases

Bgee database

Pcca gene expression

BioGPS

BioGPS

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order PCCA cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

Miscellaneous

Reactome

Reactome Event:Metabolism

Reactome Entity:P14882

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

Pathways from PubChem

Interactions

General gene information
Markers, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

RGD

EnsemblRapid

AllianceGenome

UCSC

KEGG

Reactome

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Pcca propionyl-CoA carboxylase subunit alpha [Rattus norvegicus]
Pcca propionyl-CoA carboxylase subunit alpha [Rattus norvegicus]
Gene ID:687008

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