Klhl25 kelch-like family member 25 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Klhl25 kelch-like family member 25 [ Rattus norvegicus (Norway rat) ]
Gene ID: 293023, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Official Symbol

Klhl25provided by RGD

Official Full Name

kelch-like family member 25provided by RGD

Primary source

RGD:1310815

See related

EnsemblRapid:ENSRNOG00000010959 AllianceGenome:RGD:1310815

Gene type

protein coding

RefSeq status

PROVISIONAL

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

RGD1310815

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Liver (RPKM 65.3), Kidney (RPKM 54.0) and 9 other tissues See more

Orthologs

human mouse all

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Genomic context

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See Klhl25 in Genome Data Viewer

Location:

1q31

Exon count:

5

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 1 | NC_086019.1 (139134655..139159898)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 1 | NC_051336.1 (129724894..129750142)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 1 | NC_005100.4 (137333880..137359107, complement)

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Chromosome 1 - NC_086019.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086019.1 Chromosome 1 Reference GRCr8

NC_051336.1 Chromosome 1 Reference mRatBN7.2 Primary Assembly

NC_005100.4 Chromosome 1 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Yanagiya A, et al. Mol Cell, 2012 Jun 29. PMID 22578813, Free PMC Article

2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Submit: New GeneRIF Correction

General gene information

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Markers

RH138666 (e-PCR)

UniSTS:220753

Homology

NCBI Orthologs
Orthologs from OrthoDB

Clone Names

MGC116251

Gene Ontology Provided by RGD

Items 1 - 2 of 2

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Function | Evidence Code | Pubs

enables ubiquitin-like ligase-substrate adaptor activity

ISO
Inferred from Sequence Orthology
more info

enables ubiquitin-like ligase-substrate adaptor activity

ISS
Inferred from Sequence or Structural Similarity
more info

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Items 1 - 12 of 12

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Process | Evidence Code | Pubs

involved_in negative regulation of fatty acid biosynthetic process

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in positive regulation of fatty acid oxidation

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of fatty acid oxidation

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in protein ubiquitination

IEA
Inferred from Electronic Annotation
more info

involved_in protein ubiquitination

ISO
Inferred from Sequence Orthology
more info

involved_in protein ubiquitination

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in regulation of translational initiation

ISO
Inferred from Sequence Orthology
more info

involved_in regulation of translational initiation

ISS
Inferred from Sequence or Structural Similarity
more info

involved_in ubiquitin-dependent protein catabolic process

ISO
Inferred from Sequence Orthology
more info

involved_in ubiquitin-dependent protein catabolic process

ISS
Inferred from Sequence or Structural Similarity
more info

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Component | Evidence Code | Pubs

part_of Cul3-RING ubiquitin ligase complex

ISO
Inferred from Sequence Orthology
more info

part_of Cul3-RING ubiquitin ligase complex

ISS
Inferred from Sequence or Structural Similarity
more info

located_in cytoplasm

ISO
Inferred from Sequence Orthology
more info

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General protein information

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Preferred Names

kelch-like protein 25

Names

ENC-2

ectoderm-neural cortex protein 2

kelch-like 25

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001039006.1 → NP_001034095.1 kelch-like protein 25

See identical proteins and their annotated locations for NP_001034095.1

Status: PROVISIONAL

Source sequence(s)

BC099111

UniProtKB/Swiss-Prot

Q4KLM4

UniProtKB/TrEMBL

A6JC16

Related

ENSRNOP00000089869.1, ENSRNOT00000097328.2

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086019.1 Reference GRCr8

Range

139134655..139159898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_008759505.4 → XP_008757727.1 kelch-like protein 25 isoform X1

See identical proteins and their annotated locations for XP_008757727.1

UniProtKB/Swiss-Prot

Q4KLM4

UniProtKB/TrEMBL

A6JC16

Related

ENSRNOP00000102094.1, ENSRNOT00000123188.1

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

2. XM_063284515.1 → XP_063140585.1 kelch-like protein 25 isoform X1

UniProtKB/Swiss-Prot

Q4KLM4

UniProtKB/TrEMBL

A6JC16

3. XM_006229380.4 → XP_006229442.1 kelch-like protein 25 isoform X1

See identical proteins and their annotated locations for XP_006229442.1

UniProtKB/Swiss-Prot

Q4KLM4

UniProtKB/TrEMBL

A6JC16

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH473980.1 | EDM08543.1
| EDM08545.1
genomic | JAXUCZ010000001.1 (139134655..139159898) | None | BN/NHsdMcwi
mRNA | BC099111.1 | AAH99111.1
mRNA | FQ230538.1 | None | Sprague-Dawley

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Protein Accession | Links
GenPept Link | UniProtKB Link
Q4KLM4.1 | GenPept | UniProtKB/Swiss-Prot:Q4KLM4

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

Interologous Interaction Database

Interologous Interaction Database

MilliporeSigma

Klhl25 products

Molecular Biology Databases

Bgee database

Klhl25 gene expression

BioGPS

BioGPS

CTD: Comparative Toxicogenomics Database

CTD: Comparative Toxicogenomics Database - KLHL25

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order Klhl25 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

Miscellaneous

Reactome

Reactome Event:Immune System

Reactome Entity:Q4KLM4

Reactome Event:Metabolism of proteins

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

General gene information
Markers, Clone Names, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

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EnsemblRapid

AllianceGenome

UCSC

MGC

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Klhl25 kelch-like family member 25 [Rattus norvegicus]
Klhl25 kelch-like family member 25 [Rattus norvegicus]
Gene ID:293023

Gene

Gene Links for GEO Profiles (Select 117225375) (1)
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